Papain + Urea
Uses of Papain + Urea
Papain + Urea is used to manage various skin conditions, particularly chronic wounds. It belongs to the group of enzymatic debriding agents.
Secondary uses include the management of post-surgical wounds, burns, skin damaged by radiation therapy, and infected wounds.
Side effects of Papain + Urea
Burning sensation
Skin irritation or redness
Itching
Skin tenderness
How Papain + Urea works
Papain is a powerful enzyme that breaks down protein structures in dead tissue present in chronic wounds, thereby aiding the removal of this damaged tissue.
Urea aids this process by reshaping proteins, making them more susceptible to papain's enzymatic activity. Furthermore, it has mild antiseptic properties and raises the moisture content in the skin and wound area, helping to soften the dead tissue for easier removal.
Therefore, these two ingredients work together to clean the wound surface and create an ideal environment for healing. They have a selective action, only impacting necrotic tissue whilst leaving healthy skin unaffected.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Papain + Urea is available as topical creams, ointments, or solutions intended to be applied on the skin, directly on the wound or affected area.
Age and Dose Restrictions
This combination medication is intended for both adults and children.
Contraindications
Papain + Urea is contraindicated in patients with known papaya, papain enzyme, or urea allergies. It should not be used on actively bleeding wounds or by patients diagnosed with bleeding disorders.
Other Medications to Avoid
No major medicinal interactions have been reported with the topical use of Papain + Urea; however, you should always inform your doctor about all medicines you are currently taking to avoid potential interactions.
Overdose and Missed Dose
Overdose of Papain + Urea is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects. If you suspect an overdose or if this medicine is accidentally swallowed, contact your doctor immediately.
If you miss applying this medicine, do it as soon as you remember. However, if it is close to the next application's timing, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless, resolving once you discontinue using this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor immediately.
If there is a burning sensation after application, try applying the medicine at a different time of day.
Staying well-hydrated might help manage skin tenderness or irritation.
Use in Driving and Operating Machinery
Papain + Urea does not affect your ability to drive or operate machinery as it is applied topically.
Use in Pregnancy and Lactation
The safety of using Papain + Urea during pregnancy and breastfeeding has not been established. It is advisable to consult your doctor before using this medication if you are pregnant, planning to become pregnant, or nursing.
Caution in Other Conditions
Patients with known allergies to papaya, papain enzyme, or urea should exercise caution when using this medication. It should also be used with caution if the patient has a known bleeding disorder.
Special Dietary and Lifestyle Recommendations
Maintaining a balanced diet, adequately hydrating yourself, avoiding smoking, and getting proper rest and sleep are critical for wound healing.
Frequently asked questions
Can I use Papain + Urea for all types of wounds?
Papain + Urea is primarily used for chronic wounds like pressure ulcers, diabetic foot ulcers, and venous leg ulcers. It can also be used on post-surgical wounds, burns, skin damaged by radiation therapy, and infected wounds. However, you should always consult your doctor before applying it to any type of wound.
Does Papain + Urea have any effects on the heart or blood pressure?
There are no known effects of Papain + Urea on heart function or blood pressure when used topically as directed. This medication acts locally at the site of application and is not known to impact systemic functions.
Can Papain + Urea be used on children?
The safety and efficacy of Papain + Urea in children have not been extensively studied. It should be used in paediatric patients only under the guidance of a doctor.
Is Papain + Urea safe for people with diabetes?
Yes, Papain + Urea is commonly used for managing diabetic foot ulcers. It helps to remove dead skin and promote healing of wounds, which can be beneficial in diabetic patients who often have delayed wound healing.
Can I apply Papain + Urea on a bleeding wound?
Papain + Urea should not be used on wounds that are actively bleeding or in patients with a bleeding disorder. If your wound is bleeding, seek immediate medical attention.
Does Papain + Urea affect my immunity?
There is no evidence to suggest that topical application of Papain + Urea affects your immune system. This medication acts locally at the site of application to help promote wound healing.
How much time does Papain + Urea take to work?
You may start to notice improvement in wound healing within a few days of starting treatment with Papain + Urea. However, complete healing may take several weeks depending on the size and severity of the wound.
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