Permethrin
Uses of Permethrin
Permethrin primarily serves to manage scabies and head lice infestations in adults and children aged 2 months and above. It falls under the classification of pyrethroids - a type of antiparasitic agent.
Side effects of Permethrin
Itching
Redness at the application site
Tingling or numbness of the skin
Burning sensation
How Permethrin works
Permethrin is a pyrethroid, a class of antiparasitic agents.
It works by acting on the nervous system of parasites such as lice and mites. Specifically, Permethrin interferes with sodium channels in nerve cell membranes leading to extended depolarisation and paralysis of these organisms. The resulting paralysis causes the death of the lice, mites and their eggs. The selective toxicity of Permethrin is due to its greater effect on the nervous system of insects compared to mammals; it is over 2000 times more toxic to insects than humans due to its poor absorption through human skin and rapid metabolism.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Permethrin can be applied topically (cream).
Age and Dose Restrictions
Permethrin can be used by both adults and children aged 2 months and above.
Contraindications
Permethrin is contraindicated in individuals who have a known hypersensitivity to the medication, chrysanthemums, pyrethrins or any component of the formulation.
Other Medications to Avoid
This medicine may interact with other topical medications for example, corticosteroids (such as hydrocortisone, mometasone), and retinoids (such as tretinoin, adapalene).
Overdose and Missed Dose
Overdose of Permethrin is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
If you miss applying Permethrin at the designated time, do it immediately once you remember. However, if it is near the time for the next application, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage the side effects of skin dryness.
Applying Permethrin at night before bed could prevent discomfort caused by irritation or stinging during your daily activities.
Use in Driving and Operating Machinery
Since Permethrin is a topical application medicine, it does not affect your ability to drive or operate heavy machinery.
Use in Pregnancy and Lactation
It should only be used if the potential benefits clearly outweigh the risks. Pregnant or nursing women should consult their doctor before using this medication.
Caution in Other Conditions
Patients with a history of allergies, asthma, or skin conditions need to exercise caution when using Permethrin.
Special Dietary and Lifestyle Recommendations
Regularly washing your clothes, bedding, and towels in hot water can help prevent reinfection or transmission of scabies or lice.
Avoid sharing personal items such as combs, hats, towels, and clothes to prevent the spread of lice or scabies.
Practising good personal hygiene can also help manage and prevent scabies or lice infestations.
Frequently asked questions
Is it safe to use Permethrin daily?
The frequency and duration of use of Permethrin should be strictly as per your doctor's prescription. Do not prolong or increase the application without consulting your doctor.
How long does it take for Permethrin to work?
You may start noticing improvements within a few days of starting the treatment with Permethrin. However, the total duration of treatment may vary depending on the severity of the infection.
When should I apply Permethrin cream?
Permethrin cream is typically applied at bedtime as it needs to be left on the skin for 8-14 hours and then washed off.
Is Permethrin available over the counter or do I need a prescription?
Permethrin usually requires a prescription from a doctor and is typically not available as an over-the-counter medication.
Does Permethrin affect mood or behaviour?
Permethrin is not directly associated with affecting mood or behaviour. However, if you notice any abnormal mood changes after using Permethrin, consult your doctor immediately.
Is Permethrin considered a vegan or vegetarian medicine?
Permethrin is a synthetic compound and does not contain any animal-derived ingredients. However, if you have concerns about specific excipients or the manufacturing process due to dietary restrictions or ethical reasons, consult your doctor or pharmacist.
Can Permethrin be used for pets?
While some Permethrin products are marketed for use on pets, it is crucial to consult a vet before using any medication on your furry friends.
Permethrin in other salts
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