Sofosbuvir + Velpatasvir

Dosage Forms Available

• The medicine Sofosbuvir + Velpatasvir is available as a fixed-dose combination tablet for oral administration only.

Age and Dose Restrictions

• The medicine Sofosbuvir + Velpatasvir is intended for use in adults and children aged 3 years and older.

Contraindications

• The medicine Sofosbuvir + Velpatasvir is contraindicated in patients who have severe hypersensitivity to either of its active components, sofosbuvir or velpatasvir.

• The medicine is not recommended for patients with moderate or severe hepatic impairment (Child-Pugh B or C).

Other Medications to Avoid

• This combination may interact with potent P-glycoprotein (P-gp) inducers (such as rifampicin and carbamazepine), moderate to potent cytochrome P450 (CYP) inducers (like phenytoin and St. John's wort), certain anticonvulsants (phenobarbital and oxcarbazepine), and antimycobacterial (like rifabutin and rifapentine).

Overdose and Missed Dose

• An overdose of this medication could potentially lead to severe adverse health effects. If you suspect an overdose, seek immediate medical attention.

• If you miss a dose, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to make up for the missed one.

Management of Side Effects

Most side effects of this medicine are temporary and resolve on their own once the medicine is discontinued. However, if you experience severe side effects or symptoms worsen, consult your doctor immediately.

• Drinking plenty of water can help manage some side effects, such as dry mouth and headache.

• Resting and avoiding strenuous activities may help manage symptoms like fatigue.

Use in Driving and Operating Machinery

• This medication may cause dizziness or sleepiness in some individuals. Hence, it is advisable to avoid driving or operating heavy machinery while on this medication.

Use in Pregnancy and Lactation

• The use of Sofosbuvir + Velpatasvir during pregnancy and lactation should be done under the advice and supervision of a doctor.

Caution in Other Conditions

• Patients with renal or hepatic impairment should use Sofosbuvir + Velpatasvir with caution, no dosage adjustments are required in these conditions, but close monitoring is advised.

Special Dietary and Lifestyle Recommendations

• Maintaining a balanced diet rich in fruits, vegetables, and lean proteins could support overall health when managing chronic hepatitis C virus infection.

• Regular, moderate physical activity could help boost your immunity and general well-being.

• Maintain good personal hygiene to prevent the spread of the hepatitis C virus.