Actibile 300 Mg Tablet 10

Actibile 300 Tablet 10

Zydus Cadila

Strip of 10 Units

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MRP ~~₹458.9~~

₹376.3

₹45.89/Units

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Composition

Ursodeoxycholic Acid (300 Mg)

Strength:

150 MG 300 MG 75 MG

Actibile 300 Tablet is primarily used to dissolve and prevent cholesterol gallstones in the gallbladder. It belongs to a class of medications known as bile acids.

In addition to managing cholesterol gallstones, this tablet is also utilised in the management of primary biliary cholangitis, an autoimmune disease of the liver. It's beneficial as well in handling liver and biliary diseases linked with cystic fibrosis in children over the age of six. This medication aids in reducing cholesterol production in the liver and breaking down cholesterol that has formed into gallstones, thereby having a protective effect on liver cells.

It's vital to take this medication as your doctor has advised. Make sure to discuss any pre-existing conditions or ongoing medications you're on before starting this tablet. If you observe any side effects while on this medication, immediately inform your doctor. For optimal results, continue using this medicine for the entire duration prescribed by your doctor.

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Actibile 300 Tablet is beneficial for managing:

Cholesterol gallstones in the gallbladder, by dissolving and preventing their formation
Primary biliary cholangitis, an autoimmune liver disease
Biliary and liver complications linked with cystic fibrosis in children above 6 years old

Directions for Use of Actibile 300 Tablet 10

Here's how to correctly use Actibile 300 Tablet :

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Always take this medicine with food for maximum benefit.
Do not exceed the dose prescribed by your doctor.
Consult your doctor before discontinuing this medicine.

Actibile 300 Tablet is taken orally.

Using Actibile 300 Tablet may result in the following side effects:

Abdominal discomfort
Diarrhoea
Nausea
Rash
Dizziness
Hair loss

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Actibile 300 Tablet. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.

Here are some ways to manage common side effects:

Abdominal discomfort: Try taking Actibile 300 Tablet with food.
Diarrhoea: Consider taking this medicine at night if it causes you diarrhoea during the day.

Actibile 300 Tablet contains ursodeoxycholic acid (300 mg), which works on your body through several mechanisms:

Reducing Cholesterol Synthesis: Ursodeoxycholic acid helps decrease cholesterol production and secretion in bile, contributing to its therapeutic effect.
Dissolving Gallstones: It acts by dissolving cholesterol gallstones, effectively breaking down solidified cholesterol.
Improving Bile Flow: Ursodeoxycholic acid replaces more toxic bile acids and enhances the flow of bile in your system.
Providing Immunomodulatory Effects: This ingredient exerts immunomodulatory and anti-inflammatory effects that are beneficial to your body.
Protecting Liver Cells: It plays a significant role in protecting your liver cells and bile duct epithelial cells from injury and apoptosis (cell death).

Pregnancy

Caution is advised while taking Actibile 300 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you're breastfeeding, it's important to discuss the potential risks and benefits of taking Actibile 300 Tablet with your doctor.

Alcohol

There's no known interaction between alcohol and Actibile 300 Tablet. However, excessive alcohol consumption may worsen liver conditions that the medicine is used to manage.

Liver

This medicine is often prescribed for liver health issues. It is advisable to discuss liver-related concerns with your doctor before starting treatment with Actibile 300 Tablet. They will evaluate if this medicine is suitable.

Kidney

Caution is advised before using Actibile 300 Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Actibile 300 Tablet does not generally affect the ability to drive or operate machinery. But if you experience side effects like dizziness, avoid these activities and consult your doctor.

Allergy

If you have a known allergy to ursodeoxycholic acid or any other component in Actibile 300 Tablet, avoid using this medication. Always inform your doctor about your allergies.

Children

Caution is advised while giving Actibile 300 Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Actibile 300 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Actibile 300 Tablet interacts with the following medicines:

Bile Acid Sequestrants: Medicines like cholestyramine and colestipol may decrease the absorption of ursodeoxycholic acid, reducing its effectiveness.
Oestrogen-Based Medications: Hormone replacement therapy or contraceptive pills containing estrogen can increase cholesterol levels in bile, counteracting the cholesterol-reducing effect of Actibile 300 Tablet.
Antibiotics: Certain antibiotics, such as ciprofloxacin and dapsone, could lower the efficiency of this medicine.
Immunosuppressants: Medications like cyclosporine may have their levels increased when taken concurrently with Actibile 300 Tablet.

Drug-Food Interactions

Actibile 300 Tablet does not have any specific known food interactions. It's generally recommended to take this medicine with food for optimal absorption.

Drug-Disease Interactions

Actibile 300 Tablet interacts with the following diseases:

Biliary Obstruction: In patients with complete obstruction of the bile ducts, this medication should not be used as it can worsen their condition.
Liver Disease: Patients with advanced liver disease, including cirrhosis and ascites, should use this medication cautiously, as it may exacerbate their condition.
Gallbladder Inflammation: Individuals with acute inflammation of the gallbladder or bile ducts should avoid using Actibile 300 Tablet due to potential health risks.

Daily Dose

The daily dose of Actibile 300 Tablet should be taken as instructed by your doctor. This dosage may vary depending on individual factors, such as the severity of your condition and your response to the medication. It's vital to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you happen to take more than the prescribed dose of Actibile 300 Tablet, you may experience common side effects such as abdominal discomfort or nausea in a more severe form. If these symptoms persist, please consult your doctor.

Missed Dose

If you forget to take your regular dose of Actibile 300 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and continue with your regular schedule. Never alter your dosage without consulting your doctor.

Keep Actibile 300 Tablet in a tightly sealed container.
Store it in room temperature conditions, ideally below 30°C.
Shield the medicine from exposure to light and moisture.
Always place the medication out of reach of children.
Make sure you use the product well before its expiry date.

To support the effectiveness of Actibile 300 Tablet in managing cholesterol gallstones, adopt a low-cholesterol diet. Limit intake of foods high in cholesterol, such as red meat and full-fat dairy products.
If overweight, aim to gradually shed excess weight. However, avoid rapid weight loss as it could lead to gallstone formation. Regular physical activity can help achieve healthy weight loss while enhancing overall liver health.

Fact Box

Drug Category	Bile Acid
Therapeutic Category	Hepatobiliary Agent
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Cholesterol Gallstones, Primary Biliary Cholangitis

What is the main use of Actibile 300 Tablet?

It is primarily used to dissolve cholesterol gallstones and manage liver diseases like primary biliary cholangitis.

How does Actibile 300 Tablet work?

The medicine decreases cholesterol production in the liver, dissolves gallstones, and protects liver cells from damage.

How should I take Actibile 300 Tablet?

This medicine is taken orally with food. It should be swallowed whole without crushing or chewing.

Can I use Actibile 300 Tablet if I'm allergic to its components?

No, you should avoid it if you have a known hypersensitivity to ursodeoxycholic acid or any other ingredients in it.

What are the possible side effects of Actibile 300 Tablet?

Common side effects include abdominal discomfort, diarrhoea, nausea, rash, dizziness and hair loss. These are typically mild and temporary.

Can Actibile 300 Tablet interact with other medications?

Yes, it may interact with certain medications like antacids, oestrogens and antibiotics. Consult your doctor before taking it with any other medication.

How should I store Actibile 300 Tablet?

Store it at room temperature (below 30°C) in a tightly closed container, protected from light and moisture.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

5V74+4P2, Jay Prakash Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

Axcan Pharma US, Inc. (2009). HIGHLIGHTS OF PRESCRIBING INFORMATION: URSO 250 / URSO Forte (ursodiol) TABLETS [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020675s017lbl.pdf
Ursodeoxycholic acid: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01586
DailyMed - URUSA- ursodeoxycholic acid capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7aa650ea-167b-cdd8-e053-2991aa0a7896

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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