Actoid 25 Capsule 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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Composition

Acitretin (25 Mg)

Actoid 25 Capsule is primarily used to manage severe psoriasis in adults. This medicine falls under the category of synthetic retinoids, which are derived from vitamin A.

Apart from managing psoriasis, this capsule can also be used for other disorders of keratinization, such as ichthyosis and Darier's disease. These conditions are marked by excessive growth and hardening of skin cells, causing dry, scaly skin.

Before starting this medicine, it's crucial to consult with your doctor who will guide you on the correct dosage and frequency based on your condition and overall health. Ensure you inform your doctor about any pre-existing conditions or ongoing medicines that you are taking. If you experience any side effects while on this medication, promptly notify your doctor. For best results, continue using the medicine for the entire duration prescribed by your doctor.

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Actoid 25 Capsule is used for:

Management of severe psoriasis: This skin condition causes red, itchy scaly patches on the skin.
Control of disorders related to keratinization: Keratinization is a process by which skin cells harden.
Helping with ichthyosis: A family of genetic skin disorders characterised by dry, thickened, scaly skin.
Management of Darier's disease: A rare, inherited skin condition marked by persistent crusted or scaly spots.

Directions for Use of Actoid 25 Capsule 10

Use Actoid 25 Capsule in the following way:

Always swallow the capsule whole with water. Avoid chewing or sucking it.
It's best to take the capsule with your main meal as it enhances absorption.
Do not exceed the dose recommended by your doctor.
Remember, never stop using this medicine without first consulting your doctor.

Actoid 25 Capsule is taken orally.

Actoid 25 Capsule may have the following side effects:

Dry skin, lips, and mucous membranes
Itching (Pruritus)
Scaling and peeling of the skin
Hair loss
Nail disorders: These could include changes in nail colour or shape, or even separation of the nail from the nail bed.
Eye irritation
Musculoskeletal symptoms: This might present as joint pain (arthralgia) or muscle pain (myalgia).

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Actoid 25 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Dry skin, lips, and mucous membranes: Consider applying a good moisturiser regularly and staying well-hydrated.
Eye irritation: If you experience eye discomfort or change in vision after taking this medicine, rest your eyes often.

Actoid 25 Capsule contains acitretin (25 mg), which works on the body as follows:

Cell Proliferation and Differentiation Modulation: Acitretin influences how skin cells grow and differentiate or mature. This helps regulate the fast growth and hardening of skin cells seen in psoriasis and other similar disorders.
Keratinization Normalisation: The medicine normalises keratinization, which is the process where skin cells produce keratin a protein that provides strength to hair, nails, and skin tissue. By controlling this process, Actoid 25 Capsule helps reduce excessive cell growth and hardening in areas affected by psoriasis or other keratinization disorders.

Pregnancy

Actoid 25 Capsule is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Actoid 25 Capsule is contraindicated for breastfeeding/lactating women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Intake of alcohol during treatment with Actoid 25 Capsule may lead to formation of etretinate, a long-acting teratogenic metabolite. It's advisable to consult your doctor about alcohol consumption while taking this medicine.

Liver

Caution is advised while taking Actoid 25 Capsule in case of mild to moderate liver impairment. It's not recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting Actoid 25 Capsule. This medicine may affect liver function.

Kidney

Caution is advised before using Actoid 25 Capsule if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Actoid 25 Capsule might cause side effects like dizziness or blurred vision which may affect your ability to drive or use machines. Please discuss this with your doctor.

Allergy

If you are allergic to acitretin or other retinoids, avoid using Actoid 25 Capsule. Discuss any past allergies with your doctor.

Children

This medicine is not recommended to use in children.

Older Patients

Older patients should take Actoid 25 Capsule under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Actoid 25 Capsule interacts with the following medicines:

Tetracycline antibiotics: Medicines like doxycycline, minocycline and tetracycline may increase the risk of a condition known as pseudotumor cerebri (false brain tumour) when taken with Actoid 25 Capsule.
Vitamin A supplements: Taking vitamin A supplements along with Actoid 25 Capsule can lead to additive toxicity, increasing the chances of side effects.
Progestin-only contraceptives: The contraceptive efficacy of progestin-only contraceptives like norethisterone and levonorgestrel might be reduced when taken with Actoid 25 Capsule.

Drug-Food Interactions

No specific food interactions have been noted with Actoid 25 Capsule. However, it's always good practice to follow your doctor's advice regarding your diet while taking any medicine.

Drug-Disease Interactions

Actoid 25 Capsule interacts with the following diseases:

Liver Disease: If you have liver disease, taking Actoid 25 Capsule could worsen your condition.
Kidney Disease: It may also exacerbate conditions in individuals with severely impaired kidney function.
Hyperlipidaemia: Chronic abnormally elevated blood lipid levels can be adversely affected by this medicine.

Daily Dose

The daily dose of Actoid 25 Capsule is administered as advised by your doctor. It's important to remember that the amount can differ based on factors like how severe your condition is and how you respond to the medicine. Always adhere to the prescribed dosage, and never exceed it without consulting your doctor.

Over Dose

If you accidentally take more Actoid 25 Capsule than prescribed, you might experience symptoms like headache, nausea, vomiting, facial flushing, abdominal pain, and vertigo. It's best to inform your doctor in this situation.

Missed Dose

If you forget to take your Actoid 25 Capsule, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your usual schedule. Never increase your dosage without consulting your doctor.

Store Actoid 25 Capsule at a cool temperature, below 30°C.
Keep the medicine protected from light to maintain its potency.
Ensure the area is free from moisture to prevent the Capsule from degrading.
Always keep Actoid 25 Capsule out of reach of children to avoid accidental ingestion.
Remember to use this medicine before the expiry date printed on the pack.

When managing severe psoriasis with Actoid 25 Capsule, it may help to limit your intake of alcohol. This can reduce potential liver stress, as this medicine is metabolised in the liver.
Try to include a diet rich in omega-3 fatty acids like fish, flaxseeds, and walnuts. Such a diet could support skin health and may help manage psoriasis symptoms.

Fact Box

Drug Category	Cell Proliferation Modulator
Therapeutic Category	Retinoid
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Severe Psoriasis, Ichthyosis

What is Actoid 25 Capsule used for?

Actoid 25 Capsule is primarily used to manage severe psoriasis and other disorders that affect the process of skin cell growth and hardening.

How does Actoid 25 Capsule work?

This medicine contains acitretin, which helps to regulate skin cell growth and hardening, reducing the rapid skin cell overgrowth seen in conditions like psoriasis.

Can I take Actoid 25 Capsule with food?

Yes, Actoid 25 Capsule should be taken with your main meal as it enhances its absorption in the body, promoting better effects.

What precautions should I take before starting Actoid 25 Capsule?

Consult your doctor if you have liver or kidney problems, elevated blood lipid levels, or if you are pregnant or planning pregnancy within three years.

What are the side effects of Actoid 25 Capsule?

Common side effects include dry skin, itchiness, peeling skin, hair loss, nail disorders, eye irritation, and musculoskeletal symptoms like joint pain and muscle ache.

Can I drink alcohol while taking Actoid 25 Capsule?

No, alcohol can interact with acitretin in Actoid 25 Capsule resulting in a long-acting harmful metabolite which may increase the risk of birth defects.

How should I store my Actoid 25 Capsules?

Store your capsules below 30°C in a place protected from light. Keep them out of reach of children to ensure their safety.

Certified Content

Written by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

FDA. (2021). SORIATANE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019821s028lbl.pdf
ACITRETIN, ACTIMMUNE, ADEMPAS, AIMOVIG, ALDURAZYME, ALOSETRON, AMPYRA, ANABOLIC STEROIDS, ANTIBIOTICS (INJECTABLE), ANTIFUNGALS (IV), & ANTIFUNGALS, POLYENE. (2021). Prior Authorization Criteria 2021 MAPD - MMP. https://www.cigna.com/static/www-cigna-com/docs/medicare/plans-services/2021/prior-authorization-chs.pdf
Acitretin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00459
Acitretin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a601010.html
Acitretin in dermatology: a review. (2011, July 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/21720660/

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