Alzil M 55 Mg Tablet 10

Alzil M 5 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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Composition

Donepezil (5 Mg) + Memantine (5 Mg)

Alzil-M 5 Tablet is primarily used to manage moderate to severe dementia associated with Alzheimer's disease. This medication is a combination of two active ingredients and belongs to the class of medicines known as NMDA receptor antagonists and cholinesterase inhibitors.

In addition to managing Alzheimer's-related dementia, this medicine contributes to improving mental function by boosting the levels of certain natural substances in the brain. These substances are essential for memory and other cognitive processes.

It's important to take this medicine as directed by your doctor. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications. If you experience any side effects while using this medicine, report it to your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Alzil-M 5 Tablet is used for the following:

Managing moderate to severe dementia linked with Alzheimer's disease.

Directions for Use of Alzil M 5 Tablet 10

Here are some instructions on how to take Alzil-M 5 Tablet:

Swallow the tablet whole with a glass of water.
Avoid breaking, crushing or chewing the tablet.
Do not exceed the recommended dosage without consulting your doctor.
Remember, it's essential not to stop taking this medicine without speaking to your doctor first.

Alzil-M 5 Tablet is taken orally.

Alzil-M 5 Tablet may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Loss of appetite, resulting in weight loss
Headache
Dizziness
Insomnia
Abnormal dreams
Agitation: This refers to feelings of restlessness or being easily annoyed.
Urinary incontinence: This is a condition where you may lose control over your bladder.
Fatigue and pain

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Alzil-M 5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea or Vomiting: Try taking Alzil-M 5 Tablet with food or milk.
Insomnia: Consider taking Alzil-M 5 Tablet at night if it's causing you trouble sleeping.

Alzil-M 5 Tablet contains two active ingredients:

Donepezil (5 mg): This compound is a reversible inhibitor of acetylcholinesterase. Acetylcholinesterase is an enzyme responsible for breaking down acetylcholine, a neurotransmitter involved in memory and cognition. By inhibiting this enzyme, donepezil boosts the levels and duration of action of acetylcholine in the brain.
Memantine (5 mg): This compound is an uncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist. Memantine binds to NMDA receptors and blocks the activity of glutamate, a neurotransmitter that can lead to neuronal dysfunction when present in excess. By regulating glutamate activity, memantine helps prevent the neuronal damage associated with Alzheimer's disease.

Pregnancy

Caution is advised while taking Alzil-M 5 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's advised to consult your doctor before taking Alzil-M 5 Tablet.

Alcohol

While on Alzil-M 5 Tablet, it's advisable to limit alcohol intake as it may affect the way this medicine works.

Liver

This medicine is often prescribed for older patients, who may be more susceptible to liver health issues. It is advisable to discuss liver-related concerns with your doctor before starting treatment with Alzil-M 5 Tablet. They will evaluate if this medicine is suitable.

Kidney

Caution is advised before using Alzil-M 5 Tablet if you have a history of any kidney problems. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Alzil-M 5 Tablet may cause dizziness or somnolence. Be cautious when driving or operating machinery while taking this medicine.

Allergy

Alzil-M 5 Tablet is contraindicated in patients with known hypersensitivity to donepezil, memantine, piperidine derivatives, or any excipients in the formulation. If you have any known allergies, it's essential to discuss them with your doctor before starting this medication.

Children

Caution is advised while giving Alzil-M 5 Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Alzil-M 5 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Alzil-M 5 Tablet interacts with the following medicines:

Anticholinergic medications: Donepezil, an ingredient in Alzil-M 5 Tablet, could counteract the effects of anticholinergic medicines such as atropine and scopolamine.
CYP2D6 or CYP3A4 inhibitors: Medicines like fluoxetine or ketoconazole may affect the metabolism of donepezil, leading to increased levels of donepezil in the body.
Medications that make the urine alkaline: Medicines such as acetazolamide or sodium bicarbonate may decrease the excretion of memantine, another ingredient in Alzil-M 5 Tablet, potentially increasing its levels in your body.
NMDA antagonists: Co-administration with medicines like amantadine or dextromethorphan could lead to increased side effects from memantine.

Drug-Food Interactions

There are no known specific food interactions.

Drug-Disease Interactions

Alzil-M 5 Tablet interacts with the following diseases:

Cardiovascular disorders: Alzil-M 5 Tablet could potentially exacerbate symptoms in people with heart conditions.
Renal impairment: People with severe kidney conditions should avoid this medicine as it is primarily excreted unchanged through the kidneys.
Seizure disorders: Alzil-M 5 Tablet should be used with caution in individuals with a history of seizures as it may lower the seizure threshold.

Daily Dose

The daily dose of Alzil-M 5 Tablet should be taken as directed by your doctor. The dosage may vary depending on individual factors such as the severity of the condition and response to the medicine. Always follow your doctor's prescribed dosage and never exceed it without consulting your doctor.

Over Dose

If you happen to take more Alzil-M 5 Tablets than prescribed, you might feel nauseous or have vomiting or diarrhoea. In such cases, it is advisable to inform your doctor about the situation.

Missed Dose

If you forget to take your Alzil-M 5 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting your doctor.

Store Alzil-M 5 Tablet in a tightly closed container.
Keep it at room temperature, ideally between 15-30°C.
Protect it from light and moisture to maintain its efficacy.
Always keep this medicine out of reach of children.
Check the expiry date before use and do not use the tablet if it is expired.

Maintain a balanced diet with rich nutrients, especially antioxidants like vitamin E and C, which are beneficial for brain health.
Engage in regular physical activities like walking or yoga as they help improve cognition and delay the progression of symptoms related to Alzheimer's disease. Remember, consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Acetylcholinesterase Inhibitor, NMDA Antagonist
Therapeutic Category	Anti-dementia
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Moderate to Severe Alzheimer's Dementia

What is the purpose of Alzil-M 5 Tablet?

It's used to manage moderate to severe Alzheimer's dementia by enhancing certain natural brain substances needed for memory and cognitive processes.

Can Alzil-M 5 Tablet cure Alzheimer's disease?

No, it doesn't cure Alzheimer's disease. It helps manage symptoms and may slow the progression, but does not stop the underlying neurodegenerative process.

How long before Alzil-M 5 Tablet starts showing effects?

Some improvements may be noticed within a few weeks, but it could take several months to achieve the full therapeutic effect.

Can I use this medicine if I have mild Alzheimer's disease?

Alzil-M 5 Tablet is indicated for moderate to severe Alzheimer's dementia. For mild cases, it's best to consult your doctor on suitable alternatives.

What should I do if I miss a dose of Alzil-M 5 Tablet?

If you miss a dose, take it as soon as you remember unless it's close to your next dose time. Never take a double dose.

Can I use Alzil-M 5 Tablet with other Alzheimer's medications?

Avoid using this medicine with other cholinesterase inhibitors or NMDA antagonists without consulting your doctor.

What are some common side effects of Alzil-M 5 Tablet?

Common side effects include nausea, vomiting, diarrhoea, loss of appetite, headache, dizziness, insomnia, abnormal dreams and fatigue. Consult your doctor if these persist.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

MedlinePlus. (n.d.). Donepezil. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a697032.html
MedlinePlus. (n.d.). Memantine. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a604006.html
U.S. Food and Drug Administration. (2006). NDA 20-690/S-026 and NDA 21-720/S-003. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020690s026,021720s003lbl.pdf
U.S. Food and Drug Administration. (2005). NDA 21-627. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021627lbl.pdf
Donepezil. (n.d.). Retrieved 14 October 2024, from https://go.drugbank.com/drugs/DB00843
Memantine. (n.d.). Retrieved 14 October 2024, from https://go.drugbank.com/drugs/DB01043

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