Arnicor 50 Mg Tablet 10

Arnicor 50 Tablet 10

Cipla Ltd.

Strip of 10 Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Arnicor 50 Tablet is primarily used for managing symptoms of heart failure with reduced ejection fraction in adults. This combination medicine is part of the classes known as neprilysin inhibitors and angiotensin II receptor blockers (ARBs).

Aside from its main use, this tablet also aids in the reduction of hospitalisations due to heart failure. By effectively managing heart failure symptoms, it can potentially lower the risk of cardiovascular death in patients suffering from this condition.

Before starting this medication, it's important to consult your doctor who will provide the appropriate dosage and frequency based on your specific condition. Always inform your doctor about any ongoing medications or pre-existing diseases you have. If you observe any side effects while taking this medicine, notify your doctor promptly. Furthermore, ensure you continue taking this medication for the duration prescribed by your doctor for optimal results.

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Arnicor 50 Tablet is used for the following:

Managing heart failure with reduced ejection fraction in adults
Reducing the risk of heart-related death in adults suffering from heart failure
Lowering the rate of hospitalisation for heart failure in adults

Directions for Use of Arnicor 50 Tablet 10

Here's how you should take Arnicor 50 Tablet:

Swallow the tablet whole, do not crush or chew it.
You can take this medicine with or without food.
Follow your doctor's instructions on how often to take it.
Do not exceed the recommended dose without consulting your doctor.
If you must stop taking this medicine, discuss with your doctor first.

Arnicor 50 Tablet is taken orally.

Arnicor 50 Tablet may have the following common side effects:

Hypotension: This means low blood pressure, which might make you feel faint or dizzy.
Hyperkalaemia: This is a higher than normal level of potassium in your blood, which can affect your heart rhythm.
Cough
Dizziness
Renal failure: This is when your kidneys stop working properly, which can lead to swelling in your ankles, vomiting, and feeling tired or short of breath.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Arnicor 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Cough: Stay hydrated by drinking plenty of water and use a humidifier to keep the air moist.
Dizziness: Sit or lie down immediately to avoid falls, and get up slowly from sitting or lying positions.

Arnicor 50 Tablet contains two active ingredients:

Sacubitril (24 mg): This component inhibits an enzyme called neprilysin which is responsible for breaking down substances that help in reducing cardiac fibrosis and hypertrophy, promoting vasodilation and enhancing sodium excretion. By blocking this enzyme, Sacubitril increases the levels of these beneficial substances, thereby contributing to better heart health.
Valsartan (26 mg): Valsartan operates by blocking angiotensin II type-1 (AT1) receptors which relaxes blood vessels, lowers blood pressure and decreases the workload on the heart. This action helps improve cardiac output and reduces strain on the heart.

The combined effect of Sacubitril and Valsartan contributes to enhanced management of heart failure symptoms.

Pregnancy

Arnicor 50 Tablet is not recommended during pregnancy. As soon as pregnancy is detected, it's vital to stop taking this medicine. Always discuss this with your doctor.

Breastfeeding

If you are breastfeeding, the use of Arnicor 50 Tablet is not advised. It's best to consult with your doctor to understand potential risks and benefits.

Alcohol

While taking Arnicor 50 Tablet, it's important to limit your alcohol consumption. Alcohol may intensify some side effects and interfere with the effectiveness of the medicine.

Liver

It's wise to share any liver-related issues with your doctor before starting the medication.

Kidney

Arnicor 50 Tablet should be used with caution if you have kidney problems. Your doctor can provide advice based on your specific health status.

Using Machines & Driving

Taking Arnicor 50 Tablet may cause dizziness or tiredness. If you feel unsteady, avoid driving or operating heavy machinery until you know how the medicine affects you.

Allergy

If you have a history of allergies to Sacubitril or Valsartan, avoid using Arnicor 50 Tablet. Make sure your doctor knows about any allergies you have.

Children

Arnicor 50 Tablet isn't recommended for children under 18 years old. Always consult a doctor before giving any medicine to a child.

Older Patients

Older patients should use Arnicor 50 Tablet under medical supervision as they may be more susceptible to its side effects. If you're above 70 years old, it's particularly important to discuss this with your doctor before starting on this medicine.

Drug-Drug Interactions

Arnicor 50 Tablet interacts with the following medicines:

ACE inhibitors: Medicines like enalapril or lisinopril can interact with Arnicor 50 Tablet, leading to an increased risk of angioedema.
Potassium-sparing diuretics: Medicines such as spironolactone and amiloride may interact with Arnicor 50 Tablet and increase your blood potassium levels, a condition known as hyperkalaemia.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Medicines like ibuprofen and naproxen may interact with Arnicor 50 Tablet, reducing its blood pressure-lowering effect and increasing the risk of kidney problems.

Drug-Food Interactions

There are no specific foods known to interact significantly with Arnicor 50 Tablet.

Drug-Disease Interactions

Arnicor 50 Tablet interacts with the following diseases:

Angioedema: If you have a history of this condition related to previous ACE inhibitor or ARB therapy, using Arnicor 50 Tablet could increase your risk of experiencing it again.
Renal Impairment: If you suffer from kidney disease, Arnicor 50 Tablet could potentially worsen your condition.
Hyperkalaemia: If you have high potassium levels in your blood, using Arnicor 50 Tablet might further increase these levels.

Daily Dose

It's crucial to take Arnicor 50 Tablet in the exact quantity your doctor prescribes. Your dosage can vary depending on factors like how severe your condition is and how well you're responding to the medicine. Always stick to your prescribed dosage and never increase it without consulting your doctor.

Over Dose

If you accidentally take more Arnicor 50 Tablet than prescribed, you might feel dizzy or experience an unusually slow heart rate. Ensure you inform your doctor about this, so they can guide you further.

Missed Dose

In case you forget to take your Arnicor 50 Tablet, take it as soon as you remember. But if it's nearly time for your next dose, just skip the missed one and continue with your usual schedule. It's not advisable to alter your dosage without discussing with your doctor.

Store your Arnicor 50 Tablet at room temperature, ideally between 15°C and 30°C.
Keep the medicine in a dry place, away from moisture.
Ensure the medicine is stored in a safe spot where children cannot reach it.
Always check the expiry date before taking the medicine.

Incorporate a low-sodium diet into your routine to support the management of heart failure. This helps reduce fluid build-up and lowers blood pressure.
Engage in light physical activities such as gentle walking or stretching, as advised by your doctor. Regular activity can help strengthen your heart and improve circulation.

Fact Box

Drug Category	Neprilysin Inhibitor + Angiotensin II Receptor Blocker
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart failure, Reduced ejection fraction

What is Arnicor 50 Tablet used for?

Arnicor 50 Tablet is meant to manage heart failure in adults with reduced ejection fraction, thereby decreasing the risk of cardiovascular death and hospitalisation.

How does Arnicor 50 Tablet work?

The tablet contains Sacubitril and Valsartan. Sacubitril inhibits an enzyme, increasing helpful substances that relax blood vessels. Valsartan reduces the heart's workload.

Is it safe to take Arnicor 50 Tablet during pregnancy?

No, Arnicor 50 Tablet can harm the foetus when given to pregnant women. The medicine should be stopped as soon as pregnancy is detected.

Can I use Arnicor 50 Tablet if I have kidney problems?

If you have severe kidney impairment, dose adjustments might be necessary. Consulting your doctor before taking this medicine is crucial.

What are some common side effects of Arnicor 50 Tablet?

Common side effects include low blood pressure, high potassium levels, coughing, dizziness, and kidney failure. Consult your doctor if any side effect bothers you.

Should I stop nursing while using Arnicor 50 Tablet?

Yes, it's advised to stop nursing while taking this medicine as it's unknown whether it passes into breast milk.

How should I store my Arnicor 50 Tablets?

Store your tablets at room temperature between 15°C and 30°C. Keep them away from moisture to maintain their efficacy and shelf-life.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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