CompositionDebistal-GM 2 Tablet is prescribed for the management of type 2 diabetes mellitus, especially in patients whose blood sugar levels are not adequately controlled with metformin alone. It combines glimepiride, pioglitazone, and metformin to enhance insulin secretion, improve insulin sensitivity, and reduce excess glucose production in the liver. This comprehensive action supports better glycaemic control and helps lower the risk of long term diabetic complications.
Take this medicine exactly as directed by your doctor to ensure safe and effective results. Inform your healthcare provider about any existing medical conditions or ongoing treatments to minimize the risk of side effects or drug interactions. Continue the treatment regularly as prescribed and report any unusual symptoms promptly for proper medical guidance.
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Debistal GM 2 Tablet 10
Strip of 10 Units
Old MRP ₹95
MRP ₹89.06
₹44.44
₹8.91/Units
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About Debistal GM 2 Tablet 10
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Uses of Debistal GM 2 Tablet 10
Debistal-GM 2 Tablet is used to control blood sugar levels in adults with type 2 diabetes, specifically when dual-drug therapy is no longer sufficient. When combined with a healthy diet and regular exercise, it provides advanced management to keep glucose levels within a safe range.
Directions for Use of Debistal GM 2 Tablet 10
Follow these instructions while taking Debistal GM 2 Tablet:
- Swallow whole with a glass of water.
- Do not crush, cut, or chew the tablet.
- Take this tablet once daily with your first main meal.
- Ensure you take the medication at the same time each day.
Consult your doctor before altering the dosage or discontinuing.
Route of Administration
Debistal GM 2 Tablet is taken orally.
Side Effects of Debistal GM 2 Tablet 10
Debistal-GM 2 Tablet may cause abdominal pain, diarrhoea, nausea, vomiting, loss of appetite, headache, dizziness, weight gain, and swelling in the feet or ankles. Consult your doctor if these side effects continue or become troublesome.
Managing the Side Effects:
Most side effects are temporary and generally harmless, and resolve on discontinuing the use of Debistal GM 2 Tablet. However, if you experience serious side effects or worsening of symptoms, please consult your doctor.
Here are some guidelines for managing common side effects:
- Diarrhoea: Take the tablet with food.
- Abdominal pain: Take this tablet after your meal.
How Debistal GM 2 Tablet 10 Works?
Debistal GM 2 Tablet comprises three active ingredients:
- Glimepiride (2 mg): This is a sulphonylurea that stimulates your pancreas to produce more insulin, the hormone responsible for regulating blood sugar levels.
- Metformin (500 mg): As a biguanide, metformin reduces glucose production in your liver, decreases glucose absorption in your intestines, and improves insulin sensitivity, leading to reduced blood sugar levels.
- Pioglitazone (15 mg): This thiazolidinedione enhances your body's sensitivity to insulin, helping it use insulin more effectively, lowering blood sugar levels.
Safety Measures & Warnings
Pregnancy
Debistal GM 2 Tablet should be taken during pregnancy only if the benefits outweigh the potential risks to the foetus. It's advisable to consult your doctor before taking this medicine.
Breastfeeding
Breastfeeding while on Debistal GM 2 Tablet is not recommended as the metformin in it is excreted into human milk and could potentially affect nursing infants. Consult your doctor for alternatives.
Alcohol
Alcohol consumption can interfere with the effectiveness of Debistal GM 2 Tablet and could increase the risk of lactic acidosis. It's advisable to limit alcohol intake while taking this medicine.
Liver
If you have liver problems, exercise caution while taking Debistal GM 2 Tablet. It's best to discuss with your doctor before starting this medication.
Kidney
Patients with kidney issues should use Debistal GM 2 Tablet with caution due to a potential increase in side effects. Consult your doctor for guidance.
Using Machines & Driving
Debistal GM 2 Tablet may cause dizziness or blurred vision and affect your ability to drive or operate machinery. If you experience such symptoms, avoid these activities.
Allergy
If you're allergic to glimepiride, metformin, pioglitazone or any other ingredient in Debistal GM 2 Tablet, avoid taking this medicine. Inform your doctor about any allergies you have.
Children
Debistal GM 2 Tablet is not recommended for children, unless advised by a doctor, as its safety and effectiveness have not been established in this age group.
Older Patients
Elderly patients may be more susceptible to side effects like low blood sugar and heart failure caused by Debistal GM 2 Tablet. Dose adjustments and close monitoring may be necessary. Consult your doctor for guidance.
Interactions of Debistal GM 2 Tablet 10
Drug-Drug Interactions
- Insulin or other diabetes medications: When taken with Debistal GM 2 Tablet, medicines like insulin glargine and glipizide may increase the risk of hypoglycaemia.
- Diuretics: When taken with this tablet, medicines like furosemide and hydrochlorothiazide could increase the risk of heart failure.
- Cationic medicines: Medicines like amiloride, procainamide, and ranitidine might reduce metformin elimination from your body when used with this tablet.
- Inducers of CYP2C8: Medicines like rifampin, when used with this tablet, can decrease pioglitazone concentration in your body.
Drug-Food Interactions
High-fat meals: Consuming fatty foods may delay absorption of glimepiride in Debistal GM 2 Tablet, affecting blood sugar control.
Drug-Disease Interactions
Heart disease: Pioglitazone in this medicine can cause or worsen heart failure, especially if you suffer from heart disease.
Lactic acidosis: Metformin can lead to the rare but fatal lactic acidosis, a concern if you have kidney problems or severe liver disease.
Diabetes: This medication is not suitable for managing type 1 diabetes or diabetic ketoacidosis.
Bladder cancer: Increased risk of bladder cancer is associated with pioglitazone use. If you have a history of bladder cancer, inform your doctor before starting this medication.
Dosage of Debistal GM 2 Tablet 10
Daily Dose
The daily dose of Debistal GM 2 Tablet should be as instructed by your doctor. The dosage might vary based on individual health factors and how you respond to the medication. It's crucial not to exceed the prescribed dosage without consulting your doctor.
Over Dose
If you accidentally take more Debistal GM 2 Tablet than prescribed, you may experience dizziness, weakness, or stomach discomfort. If these symptoms persist or worsen, inform your doctor.
Missed Dose
In case you forget to take a dose of Debistal GM 2 Tablet, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Don't increase your dosage without consulting your doctor.
Storage
Store at room temperature, ideally between 20°C and 25°C.
Keep away from direct sunlight and moisture to maintain efficacy.
Keep away from children.
Check expiry date before use.
Diet & Lifestyle
Incorporate a balanced diet rich in fibre, fruits, vegetables, and lean proteins to stabilise blood sugar levels. Limit your intake of sugary foods and drinks.
Regular physical activity like at least 30 minutes of moderate-intensity brisk-walking or cycling can improve insulin sensitivity and control blood sugar.
Fact Box
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Type 2 diabetes mellitus |
| Drug Category | Sulphonylurea, Biguanide, Thiazolidinedione |
| Therapeutic Category | Antidiabetic |
Frequently Asked Questions (FAQs)
What is Debistal GM 2 Tablet used for?
Managing type 2 diabetes mellitus in adults where diet and exercise alone aren't sufficient.
How does Debistal GM 2 Tablet work?
It's ingredients lower blood sugar levels by increasing insulin production, decreasing glucose production, and improving insulin sensitivity.
When should I take this medicine?
Once daily with your first main meal, unless your doctor advises otherwise.
What are the potential side effects of Debistal GM 2 Tablet?
Side effects can include nausea, vomiting, diarrhoea, abdominal pain, appetite loss, headache, dizziness, respiratory infections, weight gain and oedema.
Can Debistal GM 2 Tablet interact with other medications?
It may interact with insulin, diuretics and cationic medicines. Inform your doctor about all your medicines.
Is it safe to use during pregnancy or while breastfeeding?
Only use this medication during pregnancy if its benefits outweigh risks. It's not recommended for breastfeeding mothers due to potential risks.
What should I do in case of an overdose?
In case of overdose, seek immediate medical help. Symptoms can include severe hypoglycaemia, lactic acidosis and heart failure.
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Manufacturer details
Country of origin: INDIA
References
American Diabetes Association. (1998). Consensus Statement: Role of Cardiovascular Risk Factors in Prevention and Treatment of Macrovascular Disease in Diabetes. Diabetes Care, 21(2), 183-187. Retrieved April 1, 2024, from https://pubmed.ncbi.nlm.nih.gov/9561345/
DailyMed. (2021). Glimepiride- glimepiride tablet. Retrieved April 1, 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b857eccf-b9ff-45ba-8241-f47f5caada2a
DailyMed. (2021). Pioglitazone- pioglitazone hydrochloride tablet, film coated. Retrieved April 1, 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1f259863-21fd-4d62-b094-4eff845944df
U.S. Food and Drug Administration. (2023). Drug Approval Package: Jentadueto (linagliptin and metformin hydrochloride) Tablets. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/202293s030lbl.pdf
U.S. Food and Drug Administration. (2011). Guidance for Industry: Diabetes Mellitus — Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. Retrieved April 1, 2024, from https://www.fda.gov/downloads/drugs/drugsafety/ucm280360.pdf
U.S. Food and Drug Administration. (2011). Drug Approval Package: Actos (pioglitazone hydrochloride) Tablets. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021073s035MedG.pdf
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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