Endobloc 5 Mg Tablet 10

Endobloc 5 Tablet 10

Cipla Ltd.

Strip of 10 Units

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Composition

Ambrisentan (5 Mg)

Strength:

5 MG 10 MG

Endobloc 5 Tablet is primarily used to manage pulmonary arterial hypertension (PAH), a condition that results in high blood pressure in the arteries that transport blood from the heart to the lungs. This medication belongs to a group known as endothelin receptor antagonists.

Apart from its primary use, this medicine also contributes to improving your ability to exercise and slows down the progression of symptoms related to PAH. This medication works by blocking the effects of a substance in your body that causes your blood vessels to narrow.

It's essential that you consult your doctor for the correct dosage and frequency of this medicine. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications. Also, notify your doctor immediately if you notice any side effects while on this medication. To experience optimal results, continue taking the medicine for the duration prescribed by your doctor.

Endobloc 5 Tablet is used for the following:

Management of pulmonary arterial hypertension: This medical condition involves high blood pressure in the arteries carrying blood from your heart to your lungs.
Improvement of exercise ability: By widening blood vessels, Endobloc 5 Tablet enhances your capacity to undertake physical activity.
Slowing down symptom progression: The medicine helps delay the worsening of symptoms associated with pulmonary arterial hypertension.
Decreasing pulmonary arterial pressure: It helps reduce the pressure in your lung arteries, offering relief and improving overall condition.

Directions for Use of Endobloc 5 Tablet 10

Before starting with Endobloc 5 Tablet, take note of the following steps:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet, as it may disrupt its effectiveness.
Always remember not to discontinue using this medication without consulting your doctor.
Remember, you should always consult your doctor for personalised advice regarding usage.

Endobloc 5 Tablet is taken orally.

Endobloc 5 Tablet may have the following side effects:

Peripheral oedema: This means swelling in your limbs, often your legs.
Nasal congestion
Sinusitis: This is an inflammation or swelling of the tissue lining the sinuses.
Flushing
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Endobloc 5 Tablet. However, if you experience any serious side effects or worsening symptoms, please consult your doctor. Here are a couple of tips to manage some common side effects:

Peripheral Oedema: Try taking your medicine in the evening. This may help reduce swelling during the day.
Sinusitis: If sinusitis troubles you after taking this medicine, it might help to take it with a meal.

Endobloc 5 Tablet contains Ambrisentan (5 mg), which works on your body in the following ways:

Endothelin Receptor Antagonist: Ambrisentan is an antagonist for the endothelin receptors, specifically the type A (ETA) receptors. This means it blocks these receptors, preventing them from being activated.
Vessel Widening: By blocking the endothelin receptors, Ambrisentan helps relax and widen blood vessels, particularly those in the lungs. This reduces pulmonary vascular resistance.
Pressure Reduction: The relaxation and widening of the blood vessels decrease the pressure in your arteries, specifically the pulmonary arteries. This reduces the workload of your heart and helps manage symptoms of PAH.

Pregnancy

Endobloc 5 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Endobloc 5 Tablet is not recommended while breastfeeding. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol when taking Endobloc 5 Tablet. It is best to consult your doctor for guidance on this matter.

Liver

Caution is advised while taking Endobloc 5 Tablet in case of mild to moderate liver impairment. If you have liver problems, discuss them with your doctor before starting this medicine. This medicine may affect liver function.

Kidney

Caution is advised before using Endobloc 5 Tablet if you have a history of any kidney problems. It is a good idea to consult with your doctor before taking this medicine.

Using Machines & Driving

Endobloc 5 Tablet may cause dizziness. So, caution should be exercised while driving or operating heavy machinery when using this medication.

Allergy

If you have any known allergies to Ambrisentan or any other ingredients in Endobloc 5 Tablet, it's important to inform your doctor as it may lead to adverse reactions.

Children

Endobloc 5 Tablet is not recommended for use in children as its safety and efficacy have not been established in pediatric patients. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Endobloc 5 Tablet under medical supervision as they may be more susceptible to its side effects, such as peripheral oedema. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Endobloc 5 Tablet interacts with the following medicines:

Immunosuppressants: If taken alongside cyclosporine, it can significantly increase the level of Endobloc 5 Tablet in your blood. This is why it's generally advised to avoid concomitant use, but if it's unavoidable, the dose of Endobloc 5 Tablet should be limited to 5 mg once daily.

Drug-Food Interactions

There are no known food interactions with Endobloc 5 Tablet. You can take it with or without food.

Drug-Disease Interactions

Endobloc 5 Tablet interacts with the following diseases:

Liver Disease: People who have liver disease should exercise caution while on this medication, as ambrisentan may cause liver enzyme elevations. Regular monitoring of liver function is recommended.
Idiopathic Pulmonary Fibrosis: This medicine should not be used in patients with idiopathic pulmonary fibrosis.
Anaemia: Inform your doctor about any history of anaemia, as Ambrisentan may decrease haemoglobin levels.
Pulmonary Veno-Occlusive Disease (PVOD): Caution is advised in patients with PVOD due to the risk of pulmonary oedema.

Daily Dose

The daily dose of Endobloc 5 Tablet should be consumed as directed by your doctor. The dosage could vary depending on individual factors, such as the severity of your condition and your response to the medicine. Always adhere to your prescribed dosage and never exceed it without consulting your doctor.

Over Dose

If you accidentally take more than the prescribed dose of Endobloc 5 Tablet, you may experience side effects like headaches, dizziness, swelling in your arms and legs, or a stuffy nose. If these symptoms persist or worsen, consult your doctor.

Missed Dose

Missed a dose of Endobloc 5 Tablet? Take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without talking to your doctor.

Store your Endobloc 5 Tablet in a cool, dry place where the temperature stays below 30°C.
Keep it away from direct sunlight and moisture.
Always keep the medicine out of reach and sight of children.
It's essential to use this medicine before the expiry date printed on the packet.

As Endobloc 5 Tablet is used to manage pulmonary arterial hypertension, try reducing salt intake. High-sodium food can raise blood pressure, putting extra stress on your arteries.
Regular, low-impact exercise like walking or swimming can help to improve your lung function and overall health. However, always consult with your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Endothelin Receptor Antagonist
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Pulmonary Arterial Hypertension

What is the purpose of Endobloc 5 Tablet?

Endobloc 5 Tablet is used to manage pulmonary arterial hypertension (PAH), a condition causing high blood pressure in the arteries from the heart to the lungs.

How does Endobloc 5 Tablet work?

It contains ambrisentan, which blocks endothelin-1, a substance that narrows blood vessels. This action helps relax and widen the vessels in the lungs.

Can pregnant women take Endobloc 5 Tablet?

No, pregnant women should not take Endobloc 5 Tablet because it carries a risk of harming the unborn baby. Always consult your doctor for advice.

Are there any side effects of Endobloc 5 Tablet?

Common side effects include swelling in limbs, nasal congestion, sinusitis, and flushing. More severe side effects can include liver toxicity.

Can I take other medicines while using Endobloc 5 Tablet?

Some medications may interact negatively with Endobloc 5 Tablet. Always inform your doctor about all medicines you are currently taking.

Is Endobloc 5 Tablet safe for children?

No, the safety and effectiveness of this medicine have not been established for paediatric use. Always consult your doctor first.

How should I store my Endobloc 5 Tablet?

The tablets should be stored at room temperature (not exceeding 30°C), away from light and moisture, and kept out of reach of children and pets.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

U.S. Food and Drug Administration. (2007). NDA 022081 Ambrisentan Clinical Pharmacology and Biopharmaceutics Review(s). https://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/022081s000_ChemR.pdf. Accessed 1 April 2024.
U.S. National Library of Medicine. (n.d.). AMBRISENTAN tablet, film coated [Cipla USA Inc.]. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=37af3191-0ed3-4783-8747-065f1462f2d2. Accessed 1 April 2024.
Ambrisentan. (2024, October 21). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB06403
Ambrisentan: MedlinePlus drug information. (2023, April 15). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a612023.html

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