Eplehef 25 Mg Tablet 10

Eplehef 25 Tablet 10

Sun Pharma Laboratories Ltd.

Strip of 10 Units

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Composition

Eplerenone (25 Mg)

EpleHef 25 Tablet is primarily used to manage hypertension (high blood pressure) and heart failure. It belongs to a group of medicines known as selective aldosterone receptor antagonists.

In addition, this tablet is often prescribed as an add-on treatment when other medicines are not sufficient to control blood pressure. It also acts to improve survival in stable patients with clinical evidence of congestive heart failure following a recent myocardial infarction (heart attack).

Before starting this medicine, it's crucial that you consult your doctor for the appropriate dosage and frequency. Also, inform your doctor about any pre-existing conditions or ongoing medications. If you observe any side effects while on this medicine, notify your doctor immediately. For best results, continue taking the medicine for the duration prescribed by your doctor.

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EpleHef 25 Tablet is used for the following:

Managing essential hypertension
Assisting in the survival improvement of stable patients with left ventricular dysfunction and clinical evidence of congestive heart failure after a recent heart attack
Serving as an additional treatment for hypertension when blood pressure isn't adequately controlled by other medicines alone

Directions for Use of Eplehef 25 Tablet 10

Here's how you should take EpleHef 25 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing, chewing, or breaking the tablet.
Take the tablet at the same time each day for best results.
Do not stop taking this medicine without consulting your doctor first.

EpleHef 25 Tablet is taken orally.

EpleHef 25 Tablet may have the following common side effects:

Dizziness
Headache
Mild gastrointestinal disturbances: This can include symptoms such as diarrhoea, nausea, vomiting and flatulence.
Cough and flu-like symptoms
Increased blood creatinine and potassium levels: This means the levels of these substances in your blood might rise slightly, which your doctor will monitor.
Fatigue and weakness

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when you discontinue using Eplehef 25 Tablet. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Mild gastrointestinal disturbances: If you experience discomfort, take EpleHef 25 Tablet with food to minimise these effects.
Dizziness: If this makes you feel unsteady during the day, consider taking this medicine at bedtime to manage this effect.

EpleHef 25 Tablet contains eplerenone (25 mg), which works on the body as follows:

Selective Blockage of Mineralocorticoid Receptor: Eplerenone selectively blocks the mineralocorticoid receptor (MR), a protein that responds to the hormone aldosterone.
Regulation of Fluid Balance: Aldosterone usually triggers the body to retain sodium and water while excreting potassium. By blocking this action, eplerenone helps balance fluid levels in the body, reducing fluid overload.
Lowering Blood Pressure: The regulation of fluid balance by eplerenone leads to lowered blood pressure, which aids in managing hypertension and improving outcomes in patients with heart failure.

Pregnancy

Caution is advised while taking EpleHef 25 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you're breastfeeding, it's advisable to discuss this with your doctor before starting Eplehef 25 Tablet.

Alcohol

There's no specific information about the interaction of EpleHef 25 Tablet with alcohol. However, it's always a good idea to limit your alcohol consumption while on medication.

Liver

EpleHef 25 Tablet should be used with caution if you have liver problems. If you have any liver disease, it's best to discuss this with your doctor before starting this medicine.

Kidney

Caution is advised before using EpleHef 25 Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

EpleHef 25 Tablet may cause dizziness in some patients. If you experience this side effect, avoid driving or operating heavy machinery until you feel well enough.

Allergy

If you're allergic to eplerenone or any other ingredients in Eplehef 25 Tablet, do not take this medicine. Always inform your doctor about any known allergies before starting a new medication.

Children

EpleHef 25 Tablet is not typically prescribed for children under 18. Consult your doctor before giving this medication to a child.

Older Patients

Older patients should take EpleHef 25 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

EpleHef 25 Tablet interacts with the following medicines:

Strong CYP3A4 inhibitors: Medicines like ketoconazole and itraconazole may increase the level of Eplehef in your body, potentially leading to adverse effects.
Moderate CYP3A4 inhibitors: Medicines such as erythromycin, fluconazole, and verapamil can also raise the level of Eplehef.
ACE inhibitors: Medicines like lisinopril or losartan can increase your risk of having high potassium levels in your blood when taken with Eplehef 25 Tablet.
NSAIDs: Medicines like ibuprofen or naproxen may reduce the blood pressure-lowering effect of EpleHef 25 Tablet and increase your risk of kidney problems.
Lithium: EpleHef 25 Tablet may increase lithium levels in your body, leading to toxicity.

Drug-Food Interactions

EpleHef 25 Tablet does not have any known interactions with food. However, taking medicine as directed by your doctor is always good practice.

Drug-Disease Interactions

EpleHef 25 Tablet interacts with the following diseases:

Hyperkalemia: If you have high levels of potassium in your blood, EpleHef 25 Tablet may exacerbate this condition.
Severe Kidney Impairment: Patients with severe kidney problems should avoid taking Eplehef 25 Tablet, as it could worsen their condition.
Severe Hepatic Impairment: Those with severe liver disease should exercise caution while taking Eplehef 25 Tablet.

Daily Dose

The daily dose of EpleHef 25 Tablet is to be taken as directed by your doctor. The dosage might vary based on factors such as the severity of your condition and your response to the medication. It's crucial not to exceed the prescribed dosage without consulting your doctor.

Over Dose

If you accidentally take more EpleHef 25 Tablet than prescribed, you might experience symptoms like dizziness, headache or gastrointestinal disturbances like nausea and diarrhoea. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to take your regular dose of EpleHef 25 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without consulting with your doctor.

Keep EpleHef 25 Tablet in its original packaging, ensuring it's tightly closed.
Store at a temperature not exceeding 30°C.
Protect the medicine from exposure to light and moisture.
Always keep the tablet out of reach of children.
Use it before the expiry date indicated on the package.

Consider reducing your salt intake, as hypertension can be managed with low-salt diets. This will make it easier for EpleHef 25 Tablet to work effectively in managing your blood pressure.
If you have heart failure, aim to exercise regularly. Moderate activities like walking or swimming can help improve heart health. However, always consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Aldosterone Receptor Antagonist
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Hypertension, Heart Failure

What is EpleHef 25 Tablet used for?

EpleHef 25 Tablet is a medicine used to manage high blood pressure and heart failure in adults.

How does EpleHef 25 Tablet work?

EpleHef 25 Tablet works by blocking the action of a hormone called aldosterone, which helps reduce fluid overload and lowers blood pressure.

How should I take Eplehef 25 Tablet?

You should take EpleHef 25 Tablet orally as directed by your doctor, swallowing it whole with water, ideally at the same time daily.

Are there any side effects of Eplehef 25 Tablet?

You may experience side effects like dizziness, headache, mild stomach upsets, cough, fatigue, and increased blood creatinine and potassium levels.

What precautions should I take while on Eplehef 25 Tablet?

Patients with diabetes or moderate kidney or liver problems should use EpleHef 25 Tablet with caution. It is important to monitor serum electrolytes and kidney function regularly.

Can I take other medicines while using Eplehef 25 Tablet?

Inform your doctor about all medicines you're taking before starting Eplehef to avoid potentially dangerous interactions. Dose adjustment or monitoring may be needed.

How should I store my Eplehef 25 Tablets?

Store your tablets at room temperature (not exceeding 30°C), away from moisture and heat. Keep them in their original packaging, out of the reach of children.

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 5 years

MD Ayurveda

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 7 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

References

U.S. Food and Drug Administration. (2016). Eplerenone labeling information. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021437s013lbl.pdf
Curtis, S. P., Bockow, B., Fisher, C., Olaleye, J., Compton, A., Ko, A. T., & Reicin, A. S. (2005). Etoricoxib in the treatment of osteoarthritis over 52-weeks: a double-blind, active-comparator controlled trial [NCT00242489]. BMC Musculoskeletal Disorders, 6(1). https://doi.org/10.1186/1471-2474-6-58
Website, N. (2024a, March 25). Eplerenone. nhs.uk. https://www.nhs.uk/medicines/eplerenone/
Eplerenone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00700

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