Folitrax 25 Mg Tablet 10

Folitrax 2.5 Tablet 10

Ipca Laboratories Pvt Ltd.

Strip of 10 Units

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Composition

Methotrexate (2.5 Mg)

Strength:

25 MG 15 MG 2.5 MG 7.5 MG 5 MG 10 MG

Folitrax-2.5 Tablet is primarily utilised to manage severe, active rheumatoid arthritis in adults who haven't seen sufficient response to first-line treatments. This medicine is part of a group known as antimetabolites.

In addition to its major use, this medicine also helps manage severe psoriasis that hasn't responded adequately to other therapies. It is even used in the management of certain types of cancer and polyarticular juvenile idiopathic arthritis in children where there's an inadequate response to NSAIDs.

Before starting this medicine, you should consult your doctor who will guide you on the exact dosage and frequency based on your condition. It's crucial to inform your doctor about any pre-existing conditions or ongoing medications you might be taking. If you notice any side effects while on this medication, promptly notify your doctor. For optimal results, it's important to continue taking the medicine for the duration prescribed by your doctor.

Folitrax-2.5 Tablet is used for the following:

Management of severe psoriasis not responding to other therapies
Control of severe active rheumatoid arthritis in adults unresponsive to first-line treatments
Management of polyarticular juvenile idiopathic arthritis in children with inadequate response to NSAIDs
Control of gestational choriocarcinoma, chorioadenoma destruens, and hydatidiform mole
Used as a maintenance therapy with other chemotherapeutic agents in certain cancers

Directions for Use of Folitrax 2.5 Tablet 10

Follow these instructions while taking Folitrax-2.5 Tablet:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Folitrax-2.5 Tablet is taken orally.

Folitrax-2.5 Tablet might cause the following common side effects:

Nausea
Diarrhoea
Stomatitis: This means inflammation of your mouth and lips which might cause discomfort while eating or speaking.
Dyspepsia: Also known as indigestion, it might cause discomfort in your stomach.
Erythematous rashes: Redness on your skin that can occur due to inflammation or infection.
Pruritus: This refers to an uncomfortable sensation that makes you want to scratch your skin.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Folitrax-2.5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Dyspepsia: To manage indigestion, stay away from junk food for a few days.
Nausea: Follow the dietary recommendations provided by your doctor.

Folitrax-2.5 Tablet contains methotrexate (2.5 mg), which works on the body as follows:

Dihydrofolate Reductase Inhibition: Methotrexate blocks an enzyme called dihydrofolate reductase in your body. This enzyme is vital for making DNA, RNA, thymidylates, and proteins.
Impact on Rapidly Dividing Cells: By blocking this enzyme, methotrexate mainly affects rapidly dividing cells which makes it effective in managing conditions like psoriasis characterized by excessive growth of skin cells.
Anti-inflammatory Effect: In rheumatoid arthritis, methotrexate might work through immunosuppression which helps reduce inflammation and pain.
Action Against Malignant Tissues: When used in high doses for managing certain cancers, methotrexate inhibits cell growth and triggers cell death in malignant tissues.

Pregnancy

Folitrax-2.5 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, it's crucial to discuss this with your doctor before starting this medicine.

Breastfeeding

Breastfeeding women should not use Folitrax-2.5 Tablet. Make sure to consult your doctor to understand the potential risks and benefits.

Alcohol

Drinking alcohol while taking Folitrax-2.5 Tablet can heighten the risk of liver problems. It's recommended that you avoid alcohol consumption during your treatment period.

Liver

If you have liver problems, caution is advised while taking Folitrax-2.5 Tablet. This medicine can affect liver function, so discuss your liver health with your doctor before starting this medicine.

Kidney

People with kidney issues need to be careful while taking Folitrax-2.5 Tablet. It's advisable to discuss any kidney-related concerns with your doctor before starting treatment with this medicine.

Using Machines & Driving

Folitrax-2.5 Tablet may cause drowsiness and affect your ability to concentrate. Until you know how you respond to this medicine, be cautious while driving or operating machines.

Allergy

If you are allergic to methotrexate or any other components of Folitrax-2.5 Tablet, avoid taking this medicine. Consult your doctor for alternative medications if required.

Children

Caution is advised while giving Folitrax-2.5 Tablet to children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Folitrax-2.5 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Folitrax-2.5 Tablet interacts with the following medicines:

NSAIDs: When taken together, medicines like ibuprofen and naproxen can increase the toxicity of Folitrax-2.5 Tablet.
Antibiotics: Medications such as penicillins, sulfonamides, and tetracyclines can reduce the elimination of methotrexate, increasing its concentration in your body.
Folic acid antagonists: Medicines like sulfonamides and pyrimethamine, which work against folic acid, could enhance the side effects of methotrexate.

Drug-Food Interactions

Foods high in fibre may potentially reduce the absorption of methotrexate.

Drug-Disease Interactions

Folitrax-2.5 Tablet interacts with the following diseases:

Liver disease: If you have liver problems, using Folitrax-2.5 Tablet could worsen your condition.
Renal dysfunction: This medication could further impair kidney function in people with existing kidney diseases.
Immunodeficiency disorders: If you have a weak immune system, this medicine could increase your risk of infections.
Blood dyscrasias: For those with abnormal blood cell counts or blood disorders, this medicine might exacerbate these conditions.

Daily Dose

You should take the daily dose of Folitrax-2.5 Tablet as prescribed by your doctor. The dosage may change based on factors like the severity of your condition and how well you respond to treatment. Always follow the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

In case of an overdose, you may feel unwell or experience increased side effects like nausea, vomiting, or diarrhoea. If any of these symptoms persist, please consult your doctor.

Missed Dose

If you miss a dose of Folitrax-2.5 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Do not increase your dosage without consulting your doctor.

Store Folitrax-2.5 Tablet in a tightly closed container at room temperature.
Keep it away from light and moisture, as these can affect the medicine's effectiveness.
Always keep this medicine out of reach of children.
It's crucial to use the medicine before its expiry date.

If you're taking Folitrax-2.5 Tablet for rheumatoid arthritis, try eating foods rich in omega-3 fatty acids like fish and flaxseeds; they're known to reduce inflammation and may help manage your condition.
For those with psoriasis, avoid excessive alcohol as it may worsen your condition. Regular moderate exercise can also help reduce symptoms.

Fact Box

Drug Category	Dihydrofolate Reductase Inhibitor
Therapeutic Category	Antimetabolite
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Psoriasis, Rheumatoid Arthritis

What is Folitrax-2.5 Tablet used for?

It helps manage severe psoriasis, rheumatoid arthritis, and certain types of cancer that have not responded well to other treatments.

How does Folitrax-2.5 Tablet work in the body?

It inhibits a specific enzyme, disrupting DNA and protein formation in cells, which is especially effective against rapidly dividing cells.

How should I take this medicine?

You must take the medicine exactly as prescribed by your doctor.

Are there any side effects I should know about?

Common side effects include stomach upset, liver issues, blood cell changes, lung problems, skin rashes, and neurological symptoms like dizziness.

Are there any precautions I need to take while taking this medicine?

Women of childbearing potential must use contraception; it's not recommended during breastfeeding. Avoid alcohol and live virus vaccines during treatment.

What happens if I miss a dose of Folitrax-2.5 Tablet?

If you remember soon enough, take the missed dose; if it's nearly time for the next one, skip it.

Can I take Folitrax-2.5 Tablet with food?

Yes, taking it with or without food is fine but having it with meals may help reduce stomach-related side effects.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

125, Charkop Rd, Kandivali, Charkop, Charkop Industrial Estate, Kandivali West, Mumbai, Maharashtra 400067

Country of origin: INDIA

References

West-Ward Pharmaceuticals Corp. (2020). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf
Methotrexate: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00563
DailyMed - METHOTREXATE SODIUM tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89c05ea3-3be1-46dd-b112-29c436fd7289
Methotrexate sodium (Cancer treatment). (2008, May 21). Cancer.gov. https://www.cancer.gov/about-cancer/treatment/drugs/methotrexate
Onda, K., Honma, T., & Masuyama, K. (2023). Methotrexate-related adverse events and impact of concomitant treatment with folic acid and tumor necrosis factor-alpha inhibitors: An assessment using the FDA adverse event reporting system. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1030832

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