Itratuf 200 Mg Capsule 15

Itratuf 200 Capsule 15

Alkem Laboratories Ltd.

STRIP of 15 Units
Pack of 4 Units
STRIP of 7 Units

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MRP ~~₹371.62~~

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₹24.77/Units

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Composition

Itraconazole (200 Mg)

Strength:

100 MG 200 MG

Itratuf 200 Capsule is primarily used to manage fungal infections in the body. This medicine belongs to a group known as azole antifungals.

In addition to managing common fungal infections, this capsule is also useful in handling more complex and invasive fungal conditions. It helps in managing systemic fungal infections like histoplasmosis, blastomycosis, and aspergillosis. It's also beneficial for dealing with onychomycosis (a fungal infection of the nails), oropharyngeal and esophageal candidiasis, and cryptococcal meningitis in AIDS patients.

Before you start this medicine, it's important to discuss your current health condition and any ongoing medicines with your doctor. If you observe any unusual symptoms while taking this medicine, let your doctor know immediately. For best results, continue taking the medicine for the prescribed duration.

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Itratuf 200 Capsule is used for the following:

Managing systemic fungal infections such as histoplasmosis, blastomycosis, and aspergillosis.
Addressing onychomycosis, a fungal infection of the nails.
Controlling oropharyngeal and esophageal candidiasis.
Dealing with cryptococcal meningitis in AIDS patients.

Directions for Use of Itratuf 200 Capsule 15

To use Itratuf 200 Capsule correctly, follow these steps:

Always take this medicine with a full meal to improve absorption.
Swallow the capsule whole with a glass of water.
Do not crush, chew, or open the capsule.
For specific advice on how to take this medicine based on your health condition, consult your doctor.

Itratuf 200 Capsule is taken orally.

Itratuf 200 Capsule may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Itratuf 200 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Itratuf 200 Capsule with food.
Diarrhoea: Consider taking this medicine at night if it causes you discomfort during the day.

Itratuf 200 Capsule contains Itraconazole (200 mg), which acts on your body as follows:

Inhibits Cytochrome P450-dependent Enzyme: Itraconazole blocks a specific enzyme in fungi called lanosterol 14-alpha-demethylase. This enzyme is critical for converting lanosterol into ergosterol, an essential component of the fungal cell membrane.
Disrupts Fungal Cell Membrane: By inhibiting the production of ergosterol, itraconazole disrupts the integrity and function of the fungal cell membrane. This leads to the death of the fungus cell, thereby managing the infection.

Pregnancy

Itratuf 200 Capsule is contraindicated during pregnancy. If you are pregnant or planning to conceive, it is important to discuss this with your doctor before starting on this medicine.

Breastfeeding

There's limited data available about the use of Itratuf 200 Capsule during breastfeeding. It's recommended to consult your doctor before using this medicine if you are breastfeeding

Alcohol

You should avoid consuming alcohol while taking this medicine, as it may increase the risk of liver problems. It's advisable to speak with your doctor about safe alcohol use.

Liver

Caution is advised while taking Itratuf 200 Capsule in case of mild to moderate liver impairment. It's not recommended for severe liver diseases. If you have liver issues, discuss them with your doctor before starting on this medicine as it may affect liver function.

Kidney

If you have a history of any kidney problems, caution is advised before using Itratuf 200 Capsule. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

No specific advice has been given regarding the operation of heavy machinery or driving while under medication. Always consult your doctor if you have concerns or questions.

Allergy

If you're allergic to itraconazole or any other ingredients in Itratuf 200 Capsule, avoid taking this medicine. Discuss with your doctor for an alternative medication, if necessary.

Children

Caution is advised while giving Itratuf 200 Capsule to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Itratuf 200 Capsule under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Itratuf 200 Capsule interacts with the following medicines:

CYP3A4 substrates: Itraconazole can significantly increase the concentrations of medicines like statins and calcium channel blockers such as amlodipine and diltiazem, leading to increased medication toxicity.
Gastric acid-reducing agents: Proton pump inhibitors like omeprazole and H2-receptor antagonists like ranitidine may decrease the absorption of itraconazole.

Drug-Food Interactions

Certain foods can affect how Itratuf 200 Capsule works.

High-fat meals: These can increase the absorption of itraconazole by up to 80%.
Grapefruit juice: This should be avoided as it can increase itraconazole's levels in your body, leading to increased toxicity.

Drug-Disease Interactions

Itratuf 200 Capsule interacts with the following diseases:

Hepatic disease: Patients with liver disease should use this medicine carefully, as it may worsen their condition.
Renal impairment: Itraconazole dosage adjustments may be necessary for patients with kidney problems.
Congestive heart failure: This medicine should be used cautiously by patients with a history of heart failure, as it may worsen their condition.

Daily Dose

Your doctor will advise you on the daily dose of Itratuf 200 Capsule. This could depend on factors like severity of your condition and your response to the medication. Always stick to the dosage prescribed by your doctor, and don’t increase it without their advice.

Over Dose

If you accidentally take more than your prescribed dose of Itratuf 200 Capsule, you may experience common overdose symptoms such as nausea, vomiting, and dizziness. If these symptoms persist or worsen, it's important to inform your doctor.

Missed Dose

In case you forget to take a dose of Itratuf 200 Capsule, take it as soon as you remember. But if it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not double up on doses; always consult your doctor before making any changes to your dosage.

Store Itratuf 200 Capsule in a cool, dry place where the temperature stays below 30°C.
Keep it shielded from light and moisture to maintain its effectiveness.
Always ensure it is out of reach of children.
It's important to use the medicine before its expiry date, as indicated on the pack.

If you're taking Itratuf 200 Capsule for fungal infections, maintaining good personal hygiene can help manage your condition. Regularly washing your hands, keeping your skin clean and dry, and changing socks and underwear daily can help prevent fungal growth.
Opt for a balanced diet rich in fresh fruits, vegetables, whole grains and lean proteins to support your overall health and immune system. This can help your body fight off fungal infections more effectively.

Fact Box

Drug Category	Antifungal Agent
Therapeutic Category	Antifungal Medication
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Systemic Fungal Infections, Onychomycosis, Oropharyngeal and Esophageal Candidiasis

What is Itratuf 200 Capsule used for?

Itratuf 200 Capsule is an antifungal medication, used to manage various fungal infections such as systemic fungal infections, onychomycosis, and oropharyngeal candidiasis.

How does Itratuf 200 Capsule work?

It contains itraconazole which inhibits a key enzyme in fungi, resulting in a decrease of ergosterol, a critical part of the fungal cell membrane, leading to fungal cell death.

Should I take Itratuf 200 Capsule with food?

Yes, it's more effective when taken with a full meal. This enhances the absorption of the medicine into your body. It is highly advised to follow your doctor's instructions regarding the usage of medication.

Can I crush or open the capsules if I have difficulty swallowing?

No, the capsules must be swallowed whole. Crushing or opening them may affect their absorption and effectiveness. Consult your doctor for tailored advice.

What should I do if I miss a dose?

If you forget to take your dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one but don't double up your dose to compensate for the missed one.

Can I drink alcohol while taking Itratuf 200 Capsule?

You should avoid alcohol while taking this medicine as it may increase the risk of liver toxicity.

Are there any foods or drinks to avoid while taking this medication?

Avoid drinking grapefruit juice during treatment as it can increase plasma levels and toxicity of the medicine.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

References

U.S. National Library of Medicine. (2022). Itraconazole: MedlinePlus Drug Information. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a692049.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 55283, Itraconazole. Retrieved June 8, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Itraconazole.
U.S. Food and Drug Administration. (2018). NDA 208901 Approval Letter. Accessdata.fda.gov. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208901Orig1s000OtherR.pdf
Itraconazole. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB01167
Itraconazole for the prevention of invasive aspergillosis. (n.d.). European Medicines Agency. https://www.ema.europa.eu/en/documents/orphan-designation/eu3182024-public-summary-opinion-orphan-designation-itraconazole-prevention-invasive-aspergillosis_en.pdf

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