Lefumide 20 Tablet 10

Cipla Ltd.

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Composition

Leflunomide (20 Mg)

Strength:

20 MG 10 MG

Lefumide-20 Tablet is primarily used to manage symptoms of rheumatoid arthritis and psoriatic arthritis in adults. This medicine is part of a group of medicines known as disease-modifying antirheumatic medicines (DMARDs).

In addition to managing arthritis, this medicine suppresses the immune system. It targets the overactive immune cells involved in causing inflammation, pain, and joint damage, which are common features of rheumatoid and psoriatic arthritis.

Before starting the medicine, it is critical to consult your doctor who will guide you on the right dosage and frequency. Inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Lefumide-20 Tablet is used for the following:

Reduction of signs and symptoms in adults with active rheumatoid arthritis
Slowing down structural damage in adults with active rheumatoid arthritis
Improvement of physical function in adults with active rheumatoid arthritis
Management of symptoms in adults with active psoriatic arthritis

Directions for Use of Lefumide 20 Tablet 10

Follow these instructions while taking Lefumide-20 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing, breaking, or chewing the tablet.
Do not alter the dosage or stop taking the medicine without consulting your doctor first.

Lefumide-20 Tablet is taken orally.

Lefumide-20 Tablet may have the following common side effects:

Diarrhoea
Nausea
Abdominal pain
Oral ulcers
Hair loss
Rash
Headache
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lefumide-20 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Lefumide-20 Tablet with food.
Nausea: Consider taking this medicine after meals to lessen this effect.

Lefumide-20 Tablet contains leflunomide (20 mg). The medicine acts on the body through the following mechanisms:

Pyrimidine Synthesis Inhibition: Leflunomide blocks the formation of pyrimidine, a compound required for the multiplication of rapidly dividing cells. This includes the overactive immune cells that cause inflammation in arthritis.
Immune System Suppression: By inhibiting pyrimidine synthesis, leflunomide effectively reduces the activity of the immune system. This helps to decrease inflammation and slow the progression of rheumatoid and psoriatic arthritis.

Pregnancy

Lefumide-20 Tablet is contraindicated during pregnancy. If you're pregnant or planning to conceive, ensure to discuss this with your doctor before starting this medication.

Breastfeeding

Lefumide-20 Tablet is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

While taking Lefumide-20 Tablet, it's best to avoid alcohol as it can increase the risk of liver problems. Consult your doctor for more advice on this.

Liver

Caution is advised while taking Lefumide-20 Tablet in case of mild to moderate liver impairment. It isn't recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting Lefumide-20 Tablet. This medicine may affect liver function.

Kidney

Caution is advised before using Lefumide-20 Tablet if you have a history of any kidney problems. It's a good idea to consult your doctor before taking this medication.

Using Machines & Driving

No specific precautions are needed while using machines or driving when on Lefumide-20 Tablet. However, if you experience side effects like dizziness or fatigue, avoid such activities and consult your doctor.

Allergy

If you're allergic to leflunomide or any other ingredients of Lefumide-20 Tablet, do not take this medicine. Always check the ingredients before use and consult your doctor if you have known allergies.

Children

Lefumide-20 Tablet is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Lefumide-20 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Lefumide-20 Tablet interacts with the following medicines:

Hepatotoxic medicines: Medicines like methotrexate can interact with Lefumide-20 Tablet, potentially increasing the risk of serious liver injury.
Anticoagulants: Medicines like warfarin may interact with Lefumide-20 Tablet, potentially increasing the anticoagulant effect.
Immunosuppressants: Combined use with other immune-suppressing medicines such as azathioprine or cyclosporine may increase the risk of infections.

Drug-Food Interactions

Drug-Disease Interactions

Lefumide-20 Tablet interacts with the following diseases:

Severe liver disease: Given the potential for hepatotoxicity, patients with severe liver impairment should not take this medication.
Severe infections: Those suffering from severe active infections should not initiate Lefumide-20 Tablet until the infection is resolved.
Immune deficiency: Patients with severe immune deficiency should avoid this medication due to its immunosuppressive effects.
Bone marrow problems: As it can affect white blood cell, red blood cell, and platelet counts, it's not recommended for those with impaired bone marrow function.

Daily Dose

The daily dose of Lefumide-20 Tablet should be taken as directed by your doctor. The prescribed dosage may vary based on individual circumstances such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to your doctor's instructions and not exceed the recommended dose without seeking medical advice.

Over Dose

If you accidentally take more than the recommended dose, you might experience side effects such as nausea, abdominal discomfort, or dizziness. Should these symptoms persist, inform your doctor. Always stick to the prescribed dosage to avoid such instances.

Missed Dose

If you forget to take your Lefumide-20 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your normal schedule. Never double up your dosage without consulting your doctor.

Always keep Lefumide-20 Tablet in its original packaging.
Store it at room temperature, ideally below 25°C.
Keep it away from direct light and moisture to maintain its efficacy.
Make sure the medicine is kept out of the reach of children.
Remember to check the expiry date on the packet before using the medicine.

If you're taking Lefumide-20 Tablet for rheumatoid or psoriatic arthritis, aim to maintain a balanced diet rich in Omega-3 fatty acids (found in fish, walnuts, flaxseeds) which may help reduce inflammation.
Regular low-impact exercises like swimming or cycling can help keep your joints flexible and strong without causing pressure or pain. Always consult your doctor before starting any new exercise routine.

Fact Box

Drug Category	Pyrimidine Synthesis Inhibitor
Therapeutic Category	DMARD (Disease-Modifying Antirheumatic Medicines
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis

What is Lefumide-20 Tablet used for?

Lefumide-20 Tablet is used to manage symptoms and slow down the progression of rheumatoid and psoriatic arthritis in adults.

How does Lefumide-20 Tablet work?

Lefumide-20 Tablet works by inhibiting the production of a substance needed for rapidly dividing cells, thus reducing inflammation and slowing arthritis progression.

Can Lefumide-20 Tablet be taken with food?

You must take the medicine as directed by your doctor.

What are the common side effects of Lefumide-20 Tablet?

Side effects can include diarrhoea, nausea, abdominal pain, oral ulcers, hair loss, rash, headache, and dizziness. Consult your doctor if these persist or worsen.

Is Lefumide-20 Tablet safe during pregnancy?

No, Lefumide-20 Tablet may cause birth defects and should not be taken during pregnancy. Women must use reliable contraception during and after treatment.

What precautions should I take while using Lefumide-20 Tablet?

Inform your doctor about all your health conditions especially liver disease, immunodeficiency, bone marrow problems, diabetes, and any active or chronic infections before starting this medication.

Can Lefumide-20 Tablet interact with other medicines?

Yes, it may interact with several medications such as hepatotoxic medicines and anticoagulants like warfarin. Always inform your doctor about all medicines you're currently taking.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

Unknown, U. (2002). ARAVA tablets. In Unknown [Unknown]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20905slr007,20905se1-006_arava_lbl.pdf
ARAVA. (n.d.). ARAVA Tablets (leflunomide) 10 mg, 20 mg, 100 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
Padda, I. S., & Goyal, A. (2023, June 3). Leflunomide. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557799/
Leflunomide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01097
Leflunomide: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a600032.html

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