Napra D 250 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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Old MRP ₹93.5

MRP ~~₹87.66~~

₹70.13

₹8.77/Units

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Composition

Domperidone (10 Mg) + Naproxen (250 Mg)

Napra-D 250 Tablet is used for the prevention and management of migraine headaches, particularly mild to moderate attacks. It helps reduce the frequency, duration, and intensity of migraines, improving daily functioning and overall quality of life. It belongs to the NSAIDs and anti-emetic group of medicines.

It may be prescribed alone or in combination with other medicines. The dose and duration will depend on the severity of your condition. It will not help in the acute attack of migraine. Complete the dosage duration as your doctor prescribes, even if you do not have any symptoms.

Inform your doctor duly about any pre-existing diseases and mention all the medicines. Your doctor will carefully review and decide regarding the dosage & frequency of use of Napra-D 250 Tablet.

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Napra D 250 is used for the following condition:

Treatment and Prevention of Migraines

Swallow the Napra-D 250 Tablet with one whole glass of water
Do not open, crush, or chew the Napra-D 250 Tablet
Do not change your tablet dose or take them more often than prescribed.

Napra-D 250 Tablet is taken orally.

Common side effects of Napra-D 250 Tablet include:

Swelling on ankle/feet
Unusual tiredness
Mood changes
Hot flashes
Confusion
Headache
Ringing in the ears
Changes in sight

Managing the Side Effects:

Most side effects are temporary and generally harmless, which are resolved by discontinuing the Napra-D 250 Tablet. However, if you experience severe side effects or worsening symptoms, please consult your doctor.

Napra-D 250 Tablet comprises the following components:

Naproxen sodium (250 mg): It is a non-selective non-steroidal anti-inflammatory drug. It works by reducing prostaglandin synthesis through inhibition of COX1 and COX2 enzymes.
Domperidone (10 mg): It is an anti-emetic drug that also delays the gastrointestinal emptying. It is a prokinetic which shows the action by blocking dopamine receptors. The dopamine receptor blocking property is responsible for the antiemetic action of domperidone.

Pregnancy

Be cautious about the use of Napra-D 250 Tablet in pregnant women. It is not recommended to use Napra-D 250 Tablet in pregnancy. If the medicine is required to be taken, then consult your doctor before use.

Breastfeeding

It is safe to use the Napra-D 250 Tablet for breastfeeding. Please consult your doctor before use and advice.

Alcohol

The risk of bleeding, ulcers, and holes in the esophagus may occur. It may also lead to an increase in heart rate and a sleepy feeling when the Napra-D 250 Tablet is taken along with alcohol.

Liver

Be cautious about the use of Napra-D 250 Tablet in persons suffering from liver diseases. Consult your doctor before use in case you suffer from liver disease.

Kidney

Be cautious about using Napra-D 250 Tablet in persons suffering from kidney diseases. Consult your doctor before use in case you suffer from kidney disease.

Using Machines & Driving

If you are allergic to domperidone, naproxen sodium, and other constituents of Napra-D 250 Tablet, then do not use it. If you previously had an undesirable experience, do not use the Napra-D 250 Tablet again.

Allergy

Drowsiness and sleepiness may occur after taking Napra-D 250 Tablet. It is best to avoid using machines and driving until you feel normal again.

Children

Napra-D 250 Tablet is suitable for children over twelve years of age. If you want to give this medicine to your child. Please consult your child’s doctor.

Older Patients

Use the Napra-D 250 Tablet cautiously in elderly people with liver, kidney, and cardiac diseases. Dosage adjustments may be required. Your doctor will check your history of illnesses, health and current body status and prescribe it accordingly.

Drug-Drug Interactions

Napra-D 250 Tablet can interact with drugs, including:

Anticoagulants like warfarin effect may be reduced upon the use of Napra-D 250 Tablet
Non-steroidal anti-inflammatory medicines like ketorolac may interact with Napra-D 250 Tablet and may increase the risk of side effects of the Napra-D 250 Tablet.
ACE inhibitors like ramipril may interact with Napra-D 250 Tablet and may increase the risk of kidney injury.
Corticosteroids like prednisolone may interact with the Napra-D 250 Tablet and increase the risk of ulceration, bleeding, and inflammation.
Aminoglycoside antibiotics like amikacin may interact with Napra-D 250 Tablet and may increase the risk of kidney injury.
Antiarrhythmic medications like quinidine may interact with the Napra-D 250 Tablet and decrease the effect of the quinidine.

Drug-Disease Interactions

Napra-D 250 Tablet can interact with diseases, including:

Allergy: It may worsen upon the use of Napra-D 250 Tablet.
Kidney disease: It may worsen upon the use of Napra-D 250 Tablet.
Asthma: It may worsen upon the use of Napra-D 250 Tablet.
Heart disease: It may worsen upon the use of Napra-D 250 Tablet.
Liver disease: It may worsen upon the use of Napra-D 250 Tablet

Daily Dose

Take the daily dose of Napra-D 250 Tablet as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you take an excessive amount of Napra-D 250 Tablet by accident, getting immediate medical attention from your doctor or nearby hospital is essential. Symptoms of an overdose include extreme tiredness, drowsiness, stomach pain, heartburn, nausea, vomiting, sleepiness, uncontrolled eye movements, unusual movements of the tongue, and abnormal posture.

Missed Dose

If you forgot to take a Napra-D 250 Tablet, take it as soon as you remember. If the time for the next dosage is close, it is recommended to skip the missed one now and resume your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Napra-D 250 Tablet at room temperature between 15-25ºC.
Protect Napra-D 250 Tablet from light and moisture.
Keep Napra-D 250 Tablet away from children.
Do not use the Napra-D 250 Tablet after the expiry date has passed.

Avoid skipping meals, as irregular eating patterns contribute to migraines.
Practice stress-relief techniques like meditation, yoga, deep breathing, and mindfulness to reduce migraine triggers.
Try sleeping in a dark room during the migraine episode.
Maintain a consistent sleep schedule and ensure you get restorative sleep each night.
Engage in regular physical activity but avoid excessive exertion during the migraine attack.
Apply a cold compress to your forehead for 15 minutes to ease the pain.
Apply gentle pressure to specific painful points on your head, neck, and shoulder to relieve the migraine headache.

Fact Box

Available Dosage Types	Migraine
Habit Forming	No
Ailment	Migraine headache
Drug Category	Non-steroidal anti-inflammatory drug (NSAID)
Therapeutic Category	Migraine

What is the full form of the Napra-D 250 Tablet?

The Napra-D 250 Tablet is a combination tablet. It is composed of naproxen, sodium, and domperidone.

Does Napra-D 250 Tablet affect the kidney?

Caution is required while using the Napra-D 250 Tablet. Care should be observed in case of any kidney diseases. Consult your doctor before use and advice.

Does the Napra-D 250 Tablet make you sleepy?

Napra-D 250 Tablet may cause sleepiness. Do not indulge in activities that require your focus and attention.

What category is the Napra-D 250 Tablet?

Napra-D 250 Tablet belongs to the category of analgesic and prokinetic medicines. It is used for the treatment and prevention of migraine headaches.

Is Napra-D 250 Tablet a steroid?

No, Napra-D 250 Tablet is not a steroid. It belongs to the NSAIDs and anti-emetic group of medicines that are used for the treatment and prevention of migraine headaches.

Last Updated On 29 Sep. 2025 | 6:51AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead & Reviewer | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Naproxen 500 mg tablets - Patient Information Leaflet (PIL) - (emc). (n.d.). Org. uk. Retrieved January 11, 2024, from https://www.medicines.org.uk/emc/product/543/pil.
Holder, M. A. (2018). Naproxen 250mg, 375mg and 500mg Gastro-resistant tablets. Simplymedsonline.co.uk. https://www.simplymedsonline.co.uk/storage/otherdocuments/naproxen_pil.pdf
Domperidone 10mg Tablets - Patient Information Leaflet (PIL) - (EMC). (n.d.). Org. uk. from https://www.medicines.org.uk/emc/product/556/pil
Durbin, K. (n.d.). Naproxen. Drugs.com. https://www.drugs.com/naproxen.html.
Naproxen. (n.d.). Medlineplus.gov. MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine.https://medlineplus.gov/druginfo/meds/a681029.html
Domperidone. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB01184

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Registered Office Address

Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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