Neptaz 100 Mg Tablet 14

Neptaz 100mg Tablet 14

Mankind Pharmaceuticals Ltd.

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MRP ~~₹488.6~~

₹400.65

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Composition

Sacubitril (49 Mg) + Valsartan (51 Mg)

Neptaz 100mg Tablet is primarily used to manage certain types of heart failure in adults. This combination medicine falls under the category of neprilysin inhibitors and angiotensin II receptor blockers.

Aside from its main use, this tablet is also employed to reduce the risk of cardiovascular death and hospitalisation in adults suffering from chronic heart failure and a poor ability to pump blood efficiently to cater to the body's needs.

Consult your doctor for specific details about dosage and frequency. It’s important that you inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you notice any side effects while on this medicine, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Neptaz 100mg Tablet is used for the following:

Management of chronic heart failure in adults with reduced ejection fraction.
Reducing the risk of cardiovascular death in adults suffering from heart failure.
Lowering the probability of hospitalisation due to chronic heart failure.
Improving the heart's ability to pump blood efficiently, catering to the body's needs.
Decreasing strain on the heart, thus enhancing overall heart function.

Directions for Use of Neptaz 100mg Tablet 14

To use Neptaz 100mg Tablet correctly, follow these instructions:

Swallow the tablet whole with a glass of water. Do not crush or chew it.
Always follow your doctor's advice regarding how and when to take this medicine.
Do not alter the dose without consulting your doctor.
It's essential not to stop taking this medicine without first consulting your doctor.

Neptaz 100mg Tablet is taken orally.

The intake of Neptaz 100mg Tablet may lead to the following side effects:

Dizziness
Cough
Nausea
Fatigue
Low blood pressure: This means your blood pressure might decrease more than usual.
Kidney issues: This could mean that your kidney function may be slightly impaired.
High potassium levels in the blood: Also known as hyperkalaemia, this condition means there's an excess of potassium in your bloodstream.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Neptaz 100mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dizziness: Consider taking Neptaz 100mg Tablet at bedtime to lessen this effect.
Nausea: Try taking Neptaz 100mg Tablet with meals to reduce nausea.

Neptaz 100mg Tablet consists of two active ingredients:

Sacubitril (49 mg): This component works by inhibiting an enzyme known as neprilysin. This enzyme is responsible for breaking down natriuretic peptides in the body. By inhibiting neprilysin, sacubitril helps increase the levels of these peptides that aid in relaxing blood vessels, eliminating excess sodium and water from the body, and reducing strain on the heart.
Valsartan (51 mg): This ingredient functions by blocking the action of angiotensin II, a hormone known to cause blood vessels to narrow thereby increasing blood pressure. By blocking angiotensin II receptors, valsartan aids in relaxing and widening blood vessels which results in reducing workload on the heart.

Together, these actions contribute towards improving heart function, reducing symptoms of heart failure, and decreasing risk of hospitalisation and cardiovascular death.

Pregnancy

Neptaz 100mg Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, please discuss this with your doctor before starting this medicine.

Breastfeeding

Neptaz 100mg Tablet is not recommended for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while taking Neptaz 100mg Tablet if you consume alcohol. Alcohol may alter the effects of this medicine. Discuss this with your doctor for more information.

Liver

If you have liver health issues, caution is advised while taking Neptaz 100mg Tablet. Your doctor will guide you based on your health status.

Kidney

Caution is advised before taking Neptaz 100mg Tablet if you have a history of kidney problems. Consult your doctor before starting this medication.

Using Machines & Driving

Neptaz 100mg Tablet may cause dizziness, affecting your ability to drive or operate machinery. Do not drive or operate machinery until you know how this medicine affects you.

Allergy

If you are allergic to sacubitril or valsartan, do not take Neptaz 100mg Tablet. Always inform your doctor about any allergies before starting a new medication.

Children

Neptaz 100mg Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Neptaz 100mg Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Neptaz 100mg Tablet interacts with the following medicines:

ACE inhibitors: Medicines like enalapril and lisinopril may interact with Neptaz 100mg Tablet, potentially increasing the risk of high potassium levels in your blood (hyperkalaemia).
Potassium-sparing diuretics: When taken alongside Neptaz 100mg Tablet, diuretics like spironolactone and triamterene may raise the levels of potassium in your blood.
Potassium supplements: These supplements can further increase potassium levels when used concurrently with Neptaz 100mg Tablet.
Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as ibuprofen can reduce the blood pressure-lowering effects of Neptaz 100mg Tablet.

Drug-Food Interactions

There are no specific food items known to interact with Neptaz 100mg Tablet.

Drug-Disease Interactions

Neptaz 100mg Tablet interacts with the following diseases:

Liver disease: If you have liver disease, you may need to take a lower dose of Neptaz 100mg Tablet as it may worsen your condition.
Kidney disease: Patients with kidney disease should use caution while taking Neptaz 100mg Tablet as it could exacerbate their condition.
Diabetes: Diabetic patients should monitor their blood sugar closely while on this medication as it might impact blood sugar control.
Low Blood Pressure: People suffering from low blood pressure should be cautious while taking this medicine as it could further lower blood pressure.

Daily Dose

The Neptaz 100mg Tablet should be taken as instructed by your doctor. The dosage may vary depending on individual factors like the severity of your condition and how you respond to the medication. Never change the prescribed dosage without consulting your doctor.

Over Dose

Overdosing on Neptaz 100mg Tablet might lead to symptoms such as dizziness, nausea, or fatigue. If you experience these symptoms after taking a higher dose than prescribed, inform your doctor.

Missed Dose

If you forget to take the Neptaz 100mg Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult your doctor before making any changes to your dosage.

Store Neptaz 100mg Tablet at room temperature, ideally between 20-25 degrees Celsius.
Keep the medicine away from light and moisture to maintain its efficacy.
Always keep this medication out of reach of children for safety reasons.
Make sure to use the tablet before its expiry date for the best results.

To enhance the effectiveness of Neptaz 100mg Tablet in managing heart failure, it's important to have a diet low in salt. Excessive sodium can increase blood pressure and worsen heart conditions.
Regular physical activity, as recommended by your doctor, can help strengthen your heart and improve blood circulation, complementing the action of Neptaz 100mg Tablet.

Fact Box

Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Heart Failure Management
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Reduced Ejection Fraction

What is Neptaz 100mg Tablet used for?

Neptaz 100mg Tablet is prescribed to manage adult heart failure, specifically cases with reduced ejection fraction, to lessen the risk of cardiovascular death and hospitalization.

How does Neptaz 100mg Tablet work?

Neptaz 100mg Tablet contains sacubitril and valsartan. Sacubitril increases peptides that relax blood vessels and reduce heart strain, while valsartan widens blood vessels, reducing heart workload.

Can I take Neptaz 100mg Tablet while pregnant?

No. Neptaz 100mg Tablet could harm developing babies. If you're pregnant or planning pregnancy, consult your doctor before using this medication.

What are the side effects of taking Neptaz 100mg Tablet?

Common side effects include dizziness, coughing, nausea, fatigue, low blood pressure, kidney problems, and high potassium levels in your blood.

What precautions should I take when using Neptaz 100mg Tablet?

Inform your doctor about any allergies and medical history like liver or kidney disease, diabetes, dehydration, low blood pressure or a history of angioedema.

Can Neptaz 100mg Tablet interact with other medications?

Yes, it can interact with medicines like ACE inhibitors, aliskiren, potassium-sparing diuretics, potassium supplements, NSAIDs and lithium. Consult your doctor for advice.

How should I store Neptaz 100mg Tablet?

Store at room temperature away from light, heat and moisture. Keep the medicine out of reach of children and pets.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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