Pangraf 025 Mg Capsule 10

Pangraf 0.25 Capsule 10

Mankind Pharmaceuticals Ltd.

Strip of 10 Units

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MRP ~~₹154.38~~

₹126.59

₹15.44/Units

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Composition

Tacrolimus (0.25 Mg)

Strength:

1 MG 0.5 MG 2 MG 5 MG 0.25 MG

PanGraf 0.25 Capsule is primarily used to prevent the rejection of a transplanted organ in patients who have undergone organ transplantation surgeries. It falls under the group of medicines known as immunosuppressants.

Beyond its main use, this medicine is also part of a multi-medicine regimen used to manage the body's immune response after an organ transplant, such as a liver, kidney, or heart transplant. By suppressing the immune system, it increases the chances of the body accepting the transplanted organ.

You should take this medicine as instructed by your doctor. Make sure to inform your doctor about any current health conditions or ongoing medications before starting this medicine. If you experience any side effects while on this medicine, inform your doctor immediately. It is crucial to continue taking this medicine for the duration prescribed by your doctor for the best results.

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PanGraf 0.25 Capsule is used for the following:

Preventing organ rejection after undergoing a liver transplant
Keeping the immune system under control post-kidney transplant
Reducing the chances of heart transplant rejection by the body

Directions for Use of Pangraf 0.25 Capsule 10

Here's how you should take PanGraf 0.25 Capsule:

Swallow the capsule whole with a glass of water.
Avoid crushing, chewing, or opening the capsule.
If you have a missed dose, take it as soon as you remember, unless it's nearly time for your next dose.
It's crucial not to stop taking this medicine without consulting your doctor first.

PanGraf 0.25 Capsule is taken orally.

PanGraf 0.25 Capsule may have the following common side effects:

Tremors
Headache
Diarrhoea
Nausea and vomiting
High blood pressure
High blood sugar
Kidney problems

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of PanGraf 0.25 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking PanGraf 0.25 Capsule with food or milk.
Nausea and vomiting: Consider taking this medicine after meals to lessen this effect.

PanGraf 0.25 Capsule contains Tacrolimus (0.25 mg). Its activity in the body can be explained as follows:

Calcineurin Inhibition: Tacrolimus works by inhibiting an enzyme in your body known as calcineurin. This enzyme is crucial for the activation of T-lymphocytes, a type of white blood cell involved in the body's immune response.
Immune System Suppression: By inhibiting calcineurin, Tacrolimus effectively suppresses the activation and proliferation of T-lymphocytes. This action helps to suppress the immune system's response, thereby reducing its ability to reject the transplanted organ.

Pregnancy

Caution is advised while taking PanGraf 0.25 Capsule if you are pregnant. It is best to consult your doctor before using this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss this with your doctor before starting on PanGraf 0.25 Capsule.

Alcohol

Alcohol may interact with the functioning of PanGraf 0.25 Capsule. It's advisable to limit or avoid alcohol consumption while on this medication.

Liver

If you have liver problems, it's crucial to discuss these with your doctor before starting PanGraf 0.25 Capsule, as this medicine may affect liver function.

Kidney

Caution is advised before using PanGraf 0.25 Capsule if you have a history of any kidney problems. It's always a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

PanGraf 0.25 Capsule may cause side effects like dizziness or blurred vision which could affect your ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.

Allergy

If you are allergic to Tacrolimus or any other ingredients in PanGraf 0.25 Capsule, inform your doctor before starting this medication.

Children

PanGraf 0.25 Capsule is not recommended for children under the age of 18 years old unless specified by a doctor.

Older Patients

Older patients should take PanGraf 0.25 Capsule under medical supervision as they may be more susceptible to its side effects, especially those related to kidney and liver function.

Drug-Drug Interactions

PanGraf 0.25 Capsule interacts with the following medicines:

Antifungal Medications: Medicines like ketoconazole and clotrimazole may interact with PanGraf 0.25 Capsule, potentially altering the way it works in your body.
Antibiotics: Certain antibiotics such as erythromycin and clarithromycin can affect how PanGraf 0.25 Capsule is metabolised, potentially leading to increased side effects.
Calcium Channel Blockers: Medicines like diltiazem and nifedipine may influence the effect of PanGraf 0.25 Capsule, altering its effectiveness.

Drug-Food Interactions

PanGraf 0.25 Capsule has known interactions with:

Grapefruit: Consuming grapefruit or grapefruit juice while taking this medication can increase levels of tacrolimus in your blood, heightening the risk of side effects.

Drug-Disease Interactions

PanGraf 0.25 Capsule interacts with the following diseases:

Kidney Problems: If you have kidney issues, you need to exercise caution as this medicine could exacerbate your condition.
Liver Disorders: People with liver disease should be cautious as PanGraf 0.25 Capsule might increase the risk of further liver damage.
High Potassium Levels: This medication may further raise potassium levels in your blood if you already have a high level of potassium (hyperkalemia).

Daily Dose

Your doctor will prescribe the daily dose of PanGraf 0.25 Capsule, which can vary based on the severity of your condition and your response to the medication. Always stick to the prescribed dosage and don't exceed it without consulting your doctor.

Over Dose

Taking more than the prescribed dose of PanGraf 0.25 Capsule can potentially cause side effects such as tremors, headaches, diarrhoea, nausea, and high blood pressure. If you suspect an overdose, inform your doctor.

Missed Dose

If you miss a dose of PanGraf 0.25 Capsule, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Don't increase your dose without consulting your doctor.

Store PanGraf 0.25 Capsule at room temperature, ideally below 25 degrees Celsius.
Keep it away from direct light, heat, and moisture to maintain its efficacy.
Ensure the medicine is out of reach of children to prevent accidental consumption.
Always check the expiry date and avoid using the capsule post expiration.

As PanGraf 0.25 Capsule is used to manage organ rejection post-transplant, maintaining a balanced diet is essential. Include plenty of fruits and vegetables in your meals to strengthen your immune system.
Moderate exercise can boost your overall health. However, consult your doctor before starting any new physical activity regimen post-surgery.

Fact Box

Drug Category	Calcineurin Inhibitor
Therapeutic Category	Immunosuppressant
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Organ Transplant Rejection Prevention

What is the purpose of PanGraf 0.25 Capsule?

PanGraf 0.25 Capsule is an immunosuppressant medicine used to prevent organ rejection after transplant surgeries like liver, kidney, or heart transplants.

How does PanGraf 0.25 Capsule work?

PanGraf 0.25 Capsule contains tacrolimus which inhibits an enzyme called calcineurin, thereby reducing the body's immune response to the transplanted organ.

How should I take PanGraf 0.25 Capsule?

PanGraf 0.25 Capsule is usually taken orally. The capsules should be swallowed whole, not cut, crushed, or chewed.

What happens if I miss a dose?

If you miss a dose, take it as soon as possible unless it's nearly time for your next dose. In that case, skip the missed dose.

What are some possible side effects of PanGraf 0.25 Capsule?

Common side effects can include tremors, headaches, diarrhoea, vomiting, high blood pressure and sugar levels, kidney issues and increased risk of infections.

Can PanGraf 0.25 Capsule interact with other medications?

Yes, it can interact with certain medications like antifungals, antibiotics, calcium channel blockers and HIV medications among others. Always inform your doctor about all medicines you're taking.

How should I store PanGraf 0.25 Capsule?

Store PanGraf 0.25 Capsule at room temperature away from light, heat and moisture. Always keep them in their original packaging until use.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: INDIA

References

Tacrolimus: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00864
Astellas Pharma US, Inc. (1994). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2022). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/050708s054,050709s047,204096s010lbl.pdf
Veloxis Pharmaceuticals, Inc. (1994). ENVARSUS XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/206406s010lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (1994). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050708s052,050709s044,210115s004lbl.pdf

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