Pangraf 1 Mg Capsule 10

Pangraf 1.0 Capsule 10

Mankind Pharmaceuticals Ltd.

Strip of 10 Units

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MRP ~~₹454.94~~

₹386.7

₹45.49/Units

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Composition

Tacrolimus (1 Mg)

Strength:

1 MG 0.5 MG 2 MG 5 MG 0.25 MG

PanGraf 1.0 Capsule is primarily used to prevent organ rejection in patients who have undergone liver, kidney, or heart transplantation. This medicine belongs to a class of medications known as calcineurin inhibitor immunosuppressants.

Apart from its primary use, this medicine plays a crucial role in the prophylaxis of organ rejection, ensuring that the transplanted organ is not attacked and rejected by your body's immune system.

Before starting this medicine, it's essential to consult your doctor about the correct dosage and frequency. Inform your doctor about any pre-existing conditions or ongoing medications for optimal results. If you notice any side effects while on this medicine, notify your doctor immediately. It's important to continue taking the medicine for the duration prescribed by your doctor.

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PanGraf 1.0 Capsule is used for the following:

Prevention of organ rejection in patients who have undergone a liver transplant
Avoiding organ rejection in kidney transplant recipients
Minimising the risk of heart transplant rejection

Directions for Use of Pangraf 1.0 Capsule 10

Follow these guidelines when using PanGraf 1.0 Capsule:

Swallow the capsule whole with a glass of water. Do not chew or break it.
Consistency is key when taking this medicine.
It's essential not to stop taking this medicine without consulting your doctor first.
If you have any questions or doubts, consult your doctor for specific advice.

PanGraf 1.0 Capsule is taken orally.

PanGraf 1.0 Capsule may have the following side effects:

Tremor
Headache
Insomnia
Paresthesia: This is a sensation of tingling, pricking, or numbness often described as "pins and needles".
Nausea
Vomiting
Diarrhoea
Abdominal pain
Hypertension: High blood pressure.
Peripheral oedema: This is swelling in your extremities, usually your legs or ankles.
Hyperglycemia: Increased blood sugar levels.
Hyperkalemia: This means high potassium levels in your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of PanGraf 1.0 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here's how to manage a couple of common side effects:

Nausea: Try taking PanGraf 1.0 Capsule with food to lessen this effect.
Peripheral oedema: If you notice swelling in your legs or ankles after taking this medicine, keep them elevatedand wear compression stockings to reduce this effect.

PanGraf 1.0 Capsule contains Tacrolimus (1 mg), which works on your body as follows:

Calcineurin Inhibition: Tacrolimus inhibits an enzyme called calcineurin in your body. This enzyme is crucial for the activation and proliferation of T-cells, which are significant components of your immune response.
Reduction in Cytokine Production: By inhibiting calcineurin, Tacrolimus reduces the production of cytokines. Cytokines are substances secreted by certain cells of your immune system and have an effect on other cells. By reducing their production, Tacrolimus helps manage the immune response, preventing your body from attacking the transplanted organ.

Pregnancy

PanGraf 1.0 Capsule may cause harm to the unborn baby. If you are pregnant or planning to conceive, it is best to discuss this with your doctor before starting this medicine.

Breastfeeding

PanGraf 1.0 Capsule passes into breast milk and may harm a nursing infant. Consult your doctor to understand the potential risks and benefits.

Alcohol

The interaction of PanGraf 1.0 Capsule with alcohol is unknown. It's advisable to discuss this with your doctor.

Liver

If you have liver problems, discuss them with your doctor before starting PanGraf 1.0 Capsule as it is metabolised in the liver and may affect liver function.

Kidney

Caution is advised if you have a history of kidney issues, as PanGraf 1.0 Capsule can impact kidney function. Consult your doctor before taking this medicine.

Using Machines & Driving

No specific information is available on the effect of PanGraf 1.0 Capsule on driving or operating machines. If you experience side effects like dizziness or blurred vision, avoid such activities until you feel better.

Allergy

Do not take PanGraf 1.0 Capsule if you are allergic to tacrolimus or any other ingredients in the medicine.

Children

This medicine should only be given to children under strict medical supervision due to the risk of side effects.

Older Patients

Older patients should take PanGraf 1.0 Capsule under medical supervision as they may be more susceptible to its side effects, particularly if they have pre-existing liver or kidney conditions.

Drug-Drug Interactions

PanGraf 1.0 Capsule interacts with the following medicines:

Antifungals: Medicines like ketoconazole and itraconazole can increase the level of tacrolimus in your blood.
Anticonvulsants: Medicines such as phenytoin and carbamazepine can reduce the level of tacrolimus in your body.
medicines: These include aminoglycosides which may increase the risk of kidney damage when taken with PanGraf 1.0 Capsule.
Corticosteroids: Using steroids like prednisonealong with this medicine may increase the risk of neurotoxicity and delay wound healing.

Drug-Food Interactions

Certain foods can interact with PanGraf 1.0 Capsule:

Grapefruit: Consuming grapefruit or its juice while taking this medicine can increase tacrolimus levels in your blood due to inhibition of CYP3A4 enzyme.

Drug-Disease Interactions

PanGraf 1.0 Capsule interacts with the following diseases:

Renal Impairment: If you have kidney problems, this medicine could worsen your condition.
Liver Disease: In individuals with liver dysfunction, the metabolism of this medicine could be affected.
Diabetes Mellitus: If you have diabetes, this medicine might worsen your blood sugar control, increasing the risk of post-transplant diabetes.

Daily Dose

The daily dose of PanGraf 1.0 Capsule should be taken as advised by your doctor. The dosage can change depending on your individual response to the medication and the severity of your condition. Always adhere to your doctor's prescribed dosage and never exceed it without consulting them. For more specific details, please refer to the package insert.

Over Dose

In case of an overdose, you may experience symptoms similar to the common side effects associated with PanGraf 1.0 Capsule, such as headaches, tremors, or gastrointestinal issues like nausea and diarrhoea. If you experience any persistent or worsening symptoms, inform your doctor promptly.

Missed Dose

If you happen to miss a dose of PanGraf 1.0 Capsule, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and resume your regular dosage schedule. Never alter your dosage without first consulting with your doctor.

Store PanGraf 1.0 Capsule at room temperature, ideally below 25°C.
Keep the medicine away from light and moisture to maintain its effectiveness.
Always keep this medication out of reach of children.
Use this medicine before the expiry date printed on the packaging.

As PanGraf 1.0 Capsule is used to manage organ rejection after transplantation, it's important that you maintain a balanced diet rich in proteins, fruits, and vegetables to strengthen your immune system.
Avoid exposure to sunlight and UV light as much as possible since tacrolimus can increase the risk of skin malignancies.

Fact Box

Drug Category	Calcineurin Inhibitor Immunosuppressant
Therapeutic Category	Immunosuppressant
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Organ Rejection Prevention (Liver, Kidney, Heart Transplants)

What is the main function of PanGraf 1.0 Capsule?

It's used to prevent your body from rejecting a new heart, liver, or kidney after a transplant.

How should I take the PanGraf 1.0 Capsule?

You can take it with or without food, but be consistent. Always swallow the capsule whole; do not chew or crush it.

What if I miss a dose of PanGraf 1.0 Capsule?

Take the missed dose as soon as you remember, unless it's nearly time for the next one. Never double up doses.

Can PanGraf 1.0 Capsule interact with other medicines?

Yes, it may interact with various medicines including some antibiotics and antifungal treatments. Always inform your doctor about all medicines you're taking.

What are some possible side effects of PanGraf 1.0 Capsule?

Possible side effects include tremors, headaches, diarrhoea, high blood pressure, and changes in blood sugar levels among others.

Are there any precautions I should take while using PanGraf 1.0 Capsule?

Avoid live vaccines and limit sun exposure as this medicine can increase your risk of infections and skin cancer respectively.

Can pregnant or breastfeeding women take PanGraf 1.0 Capsule?

Consult your doctor before using this medicine if you are pregnant, planning to become pregnant or breastfeeding.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: INDIA

References

Tacrolimus: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00864
Astellas Pharma US, Inc. (1994). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2022). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/050708s054,050709s047,204096s010lbl.pdf
Veloxis Pharmaceuticals, Inc. (1994). ENVARSUS XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/206406s010lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (1994). [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050708s052,050709s044,210115s004lbl.pdf

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