Prucolpride 1 Mg Tablet 10

Prucolpride 1 Tablet 10

Steris Healthcare

Strip of 10 Units

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Composition

Prucalopride (1 Mg)

Strength:

2 MG 1 MG

Prucalopride Tablet is primarily employed to manage chronic idiopathic constipation in adults. It falls under the category of medicines known as 5-HT4 receptor agonists, which are specifically designed to improve bowel function.

This medication is particularly beneficial when other treatments, such as laxatives, have not provided adequate relief. It is particularly useful for patients with slow transit constipation who frequently develop a tolerance to stimulant laxatives.

Administering this medicine should always be under the guidance of your doctor. Ensure that your doctor is aware of any pre-existing conditions or medications you are currently taking before starting this medicine. If you experience any side effects, immediately consult your doctor. Take the medicine for the prescribed period to achieve optimal results.

Prucalopride Tablet is used for the following:

Management of chronic idiopathic constipation: This is when constipation symptoms persist for a long time without any apparent cause.
Management of slow transit constipation: It's beneficial for patients who develop tolerance to stimulant laxatives, which means their bodies no longer respond well to these medicines.

Directions for Use of Prucolpride 1 Tablet 10

Here's how you should take Prucalopride Tablet:

Take the tablet orally, with or without food.
Swallow the tablet whole with a glass of water. Avoid crushing or chewing.
The medicine is to be taken as recommended by your doctor, but do not exceed the recommended dose without consulting your doctor.
If there's no improvement in your symptoms after 4 weeks of therapy, consult your doctor.

Prucalopride Tablet is taken orally.

Prucalopride Tablet may have the following common side effects:

Headache
Nausea
Abdominal pain
Diarrhoea

In rare cases, it can also cause the following side effects:

Severe abdominal pain: This is an intense stomach ache that may require immediate attention.
Rectal bleeding: This refers to blood in your stools, which might indicate internal damage or injury.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Prucalopride Tablet . However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: You might find it helpful to take Prucalopride Tablet with food or milk.
Diarrhoea: If diarrhoea persists, you could consider taking this medicine at night.

Prucalopride Tablet contains prucalopride (1 mg) and its effects on the body are as follows:

Selective 5-HT4 receptor activation: Prucalopride acts as a selective high-affinity agonist for 5-HT4 receptors. These receptors are found in your gut and play a crucial role in controlling bowel movements.
Enhancement of peristaltic reflex: By triggering the 5-HT4 receptors, prucalopride amplifies the peristaltic reflex, which is responsible for pushing food through your digestive tract.
Increased intestinal secretion: Prucalopride also enhances intestinal secretion, further aiding in digestion and bowel function.
Overall improvement in bowel function: This medicine's overall effect results in more frequent spontaneous bowel movements, providing relief from chronic constipation symptoms.

Pregnancy

This medicine should be used with caution if you are pregnant. It is best to consult your doctor before taking Prucalopride Tablet.

Breastfeeding

If you are breastfeeding, it is recommended to exercise caution while taking Prucalopride Tablet. Check with your doctor before starting this medicine.

Alcohol

There is no specific information available on the interaction of Prucalopride Tablet with alcohol. However, it's always a good idea to avoid or limit alcohol consumption while on medication.

Liver

Prucalopride Tablet can be used by individuals with liver health issues, but caution is advised. If you have liver problems, discuss them with your doctor before starting this medicine.

Kidney

For individuals with severe kidney impairment, use of Prucalopride Tablet is contraindicated. If you have any kidney health issues, consult your doctor before taking this medicine.

Using Machines & Driving

There's no specific information suggesting that Prucalopride Tablet influences your ability to drive or operate machinery. But if you feel unwell or experience side effects like dizziness, avoid such activities until you feel better.

Allergy

If you are allergic to prucalopride or any other ingredients of Prucalopride Tablet, do not take this medicine. Always inform your doctor about any known allergies before starting a new medicine.

Children

Prucalopride Tablet is not recommended for children and adolescents under 18 years of age, as its safety and efficacy in this age group have not been established.

Older Patients

Older patients can take Prucalopride Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Prucalopride Tablet interacts with the following medicines:

CYP3A4 inhibitors: Medicines such as ketoconazole and clarithromycin can increase exposure to prucalopride when taken together, as they strongly inhibit the enzyme CYP3A4, which can affect prucalopride's metabolism.
Medicines prolonging QT interval: If you are taking medicines like amiodarone or sotalol that prolong the QT interval in your heart's electrical cycle, be cautious, as prucalopride may also have this effect.
Serotonergic agents: When taken together with Prucalopride Tablet, medications like fluoxetine or sertraline (selective serotonin reuptake inhibitors) may increase the risk of serotonin syndrome, a potentially life-threatening condition.

Drug-Food Interactions

There are no specific food items known to interact with Prucalopride Tablet. However, it's always a good idea to follow a balanced diet when on medication.

Drug-Disease Interactions

Prucalopride Tablet interacts with the following diseases:

Arrhythmias: If you have a history of irregular heartbeats, caution is advised because prucalopride can prolong the QT interval in your heart's electrical cycle.
Renal impairment: Prucalopride is contraindicated in severe renal impairment because it is excreted through the kidneys and could lead to accumulation.
Inflammatory conditions of the intestinal tract: If you suffer from severe inflammatory conditions such as Crohn's disease or ulcerative colitis, prucalopride should be avoided as it could exacerbate these conditions.

Daily Dose

Adhere to the daily dose of Prucalopride Tablet as directed by your doctor. This dosage can vary depending on factors such as the severity of your constipation and how you respond to the medication. Do not alter the prescribed dosage without consulting your doctor. For more specific details, read the package insert.

Over Dose

If you accidentally take more Prucalopride Tablet than prescribed, you may experience common side effects like headache, nausea, stomach pain, and diarrhoea. If these symptoms persist or worsen, it's important to inform your doctor.

Missed Dose

Should you forget to take your Prucalopride Tablet , take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without prior consultation with your doctor.

Keep your Prucalopride Tablet stored in their original packaging to shield them from moisture.
Store at a temperature not exceeding 30°C.
Never expose the product to extreme light, heat, or cold.
Store this medicine in a location unreachable for children and pets.
Always check the expiry date on the package before taking a tablet.

Stay well-hydrated: Chronic constipation can sometimes be eased by drinking plenty of fluids. This can help soften your stools, making them easier to pass.
Consume a high-fibre diet: A diet rich in fibre can aid bowel movement. Include whole grains, fruits, vegetables, and legumes in your daily meals. Remember to consult your doctor before making any significant changes to your diet or lifestyle.

Fact Box

Drug Category	5-HT4 Receptor Agonist
Therapeutic Category	Gastrointestinal Agent
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Idiopathic Constipation, Slow Transit Constipation

What is Prucalopride Tablet used for?

Prucalopride Tablet is used to manage chronic idiopathic constipation in adults when other medicines like laxatives have not provided adequate relief.

How does Prucalopride Tablet work?

Prucalopride Tablet works by stimulating 5-HT4 receptors in your gut, improving bowel function and relieving symptoms of constipation.

Can I Take Prucalopride Tablet with other medications?

Some medications can interact with Prucalopride Tablet, particularly those that can prolong the QT interval or have proarrhythmic properties. Always consult your doctor.

What are the side effects of Prucalopride Tablet?

Side effects include headache, nausea, abdominal pain, and diarrhoea, but these usually resolve within a few days of continued use.

Who should not take Prucalopride Tablet?

People with severe renal impairment, intestinal obstruction or severe inflammatory conditions of the intestine should not take this medicine.

Can pregnant or breastfeeding women take Prucalopride Tablet?

There is limited data on the safety of Prucalopride Tablet in pregnant or breastfeeding women. Therefore, consult your doctor if you are pregnant or breastfeeding.

How should I store Prucalopride Tablet?

Store Prucalopride Tablet at room temperature (15-30°C) in the original package to protect from moisture and keep out of reach of children and pets.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Tanaji Chowk, Ambedkar Nagar, Kurla West, Kurla, Mumbai, Maharashtra 400070

Country of origin: INDIA

References

Coremans, G. (2008, June). Prucalopride: The evidence for its use in the treatment of chronic constipation. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899805/
Camilleri, M., Kerstens, R., Rykx, A., & Vandeplassche, L. (2010). A placebo-controlled trial of prucalopride for severe chronic constipation. The New England Journal of Medicine, 362(22), 2066-2076. Retrieved April 1, 2024, from https://pubmed.ncbi.nlm.nih.gov/18509121/
U.S. Food and Drug Administration. (2018, December 14). Expedited ARIA Sufficiency Template for Pregnancy Safety Concerns. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210166Orig1s000OtherR.pdf
Quigley, E. M. (2012). Prucalopride: safety, efficacy and potential applications. Therapeutic Advances in Gastroenterology, 5(1), 23-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263983/

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