Tofe 5 Mg Tablet 10

Tofe Tablet 10

Alkem Laboratories Ltd.

Strip of 10 Units

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Composition

Tofacitinib (5 Mg)

Strength:

10 MG 5 MG

Tofe Tablet is primarily used for the management of rheumatoid arthritis, a chronic inflammatory disorder affecting your joints. This medicine belongs to a class of medicines known as Janus kinase inhibitors.

Apart from its principal use in managing rheumatoid arthritis, it is also beneficial in the control of psoriatic arthritis and ulcerative colitis. These are conditions that cause inflammation in different parts of your body—your skin and joints in psoriatic arthritis, and your large intestine in ulcerative colitis.

Your doctor will decide the appropriate dosage and frequency for you based on your medical condition. Before starting this medication, ensure you inform your doctor about any pre-existing diseases or ongoing medication. If you experience any side effects while on this medicine, notify your doctor immediately. It's vital to continue taking this medicine for the duration prescribed by your doctor for optimal results.

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Tofe Tablet is primarily used for:

Managing symptoms of moderate-to-severe rheumatoid arthritis
Keeping psoriatic arthritis under control
Reducing inflammation and pain in individuals with ankylosing spondylitis
Managing the signs and symptoms of juvenile idiopathic arthritis in children.

Here are some instructions to follow while taking Tofe Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Take the medicine at regular intervals, as prescribed by your doctor.
Do not alter the dose without consulting your doctor first.
In case you have any concerns or queries, it's advised to consult your doctor.

Tofe Tablet is taken orally.

While taking Tofe Tablet, you might experience the following common side effects:

Diarrhoea
Nausea
Upper respiratory tract infections such as infections of the nose, throat, and sinus
High blood pressure

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Tofe Tablet. However, if you feel any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here's how you can manage a couple of common side effects:

Diarrhoea: Try taking Tofe Tablet with food or milk.
Nausea: Consuming this medicine after meals could help lessen this effect.

Tofe Tablet contains tofacitinib (5 mg), which functions in your body as follows:

Janus Kinase Inhibition: Tofacitinib blocks certain proteins called Janus kinases, which are involved in the process of inflammation and joint damage in rheumatoid arthritis.
Reduces Inflammation: By inhibiting these proteins, tofacitinib effectively reduces inflammation and other symptoms associated with inflammatory disorders.
Immune Response Regulation: Tofacitinib also helps regulate the immune response, which is often overactive in conditions like rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. This action helps manage these conditions by controlling the body's immune response.

Pregnancy

Caution is advised while taking Tofe Tablet if you are pregnant. It is always a good idea to consult your doctor before taking this medicine.

Breastfeeding

Tofe Tablet is contraindicated for breastfeeding women. Make sure to discuss this with your doctor before starting this medicine.

Alcohol

Alcohol may interact with Tofe Tablet, possibly making side effects worse. Limit alcohol consumption or avoid it altogether while on this medication.

Liver

If you have liver problems, discuss them with your doctor before you start taking Tofe Tablet. This medicine could affect liver function, so caution is advised.

Kidney

If you have a history of kidney issues, you should talk to your doctor before taking Tofe Tablet. The medicine could possibly have an impact on kidney function.

Using Machines & Driving

Tofe Tablet may cause dizziness or sleepiness in some people. If affected, avoid driving or operating heavy machinery until you know how the medicine affects you.

Allergy

If you are allergic to tofacitinib or any other ingredients in Tofe Tablet, do not take this medicine without first consulting your doctor.

Children

Tofe Tablet should only be given to children under 18 years of age under medical supervision. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Tofe Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Tofe Tablet interacts with the following medicines:

Immunosuppressants: Medicines like cyclosporine and tacrolimus may interact with Tofe Tablet, potentially leading to an increased risk of infection due to a weakened immune system.
Nonsteroidal anti-inflammatory drugs (NSAIDs): When taken with Tofe Tablet, NSAIDs like ibuprofen and naproxen can enhance the potential for gastrointestinal issues such as stomach ulcers and bleeding.

Drug-Food Interactions

Tofe Tablet has known interactions with high-fat meals:

High-fat meals: Consuming a high-fat meal before taking Tofe Tablet can increase the absorption of tofacitinib, potentially leading to higher than intended concentrations in the bloodstream.
Grapefruit: Consuming grapefruit or its juice while using this medicine can increase medication levels in your blood, enhancing the risk of side effects.

Drug-Disease Interactions

Tofe Tablet interacts with the following diseases:

Liver disease: People with liver disease should exercise caution as Tofe Tablet could exacerbate their condition.
Kidney disease: Individuals suffering from kidney disease should be careful when using this medicine, as it could possibly worsen their condition.
Cardiovascular disease: People with heart conditions should use this medication cautiously as it might increase the risk of blood clots.

Daily Dose

The daily dose of Tofe Tablet should be taken as prescribed by your doctor. The dosage may vary based on factors such as your health condition and how you respond to the medication. Always follow the prescribed dosage without exceeding it, unless advised otherwise by your doctor.

Over Dose

If you take more than your prescribed dose of Tofe Tablet, you might experience overdose symptoms such as headache, diarrhoea, or feeling sick. Don't panic, but do inform your doctor about this so they can provide appropriate advice and care.

Missed Dose

If you forget to take a dose of Tofe Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, just skip the missed one and continue with your regular schedule. Never double up on doses without consulting your doctor.

Keep your Tofe Tablet in its original packaging until it is ready to use.
Store it at room temperature, ideally below 30 degrees Celsius.
Avoid exposure to direct sunlight or damp areas like the bathroom.
It's crucial to keep this medicine out of reach of children.

If you're taking Tofe Tablet for rheumatoid arthritis, consider incorporating foods rich in omega-3 fatty acids, like fish and nuts, into your diet because they can help reduce inflammation.
Regular gentle exercise such as swimming or walking can also help manage your symptoms and promote general wellbeing.

Fact Box

Drug Category	JAK Inhibitor
Therapeutic Category	Immunosuppressant
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis

What is Tofe Tablet used for?

Tofe Tablet is used to manage rheumatoid arthritis, a condition that causes inflammation and pain in the joints, by reducing swelling and discomfort.

How should I take my Tofe Tablet?

Tofe Tablet should be taken orally as instructed by your doctor with or without food.

What happens if I miss a dose of Tofe Tablet?

If you miss a dose, take it as soon as you remember. If it's near the time for your next dose, skip the missed one and continue with your schedule.

Can I drink alcohol while taking Tofe Tablet?

It's best to limit alcohol consumption while taking Tofe Tablet, as alcohol can increase the risk of stomach problems and may worsen some side effects.

What are the side effects of Tofe Tablet?

Some common side effects include headache, diarrhoea, and cold-like symptoms. Serious side effects are rare but can include infections or allergic reactions.

Can pregnant women take Tofe Tablet?

Pregnant women should avoid taking Tofe Tablet unless prescribed by a doctor. Always discuss the risks and benefits with your doctor.

How should I store my Tofe Tablet?

Store your Tofe Tablet in a cool, dry place away from direct sunlight. Keep them out of reach of children and pets.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Alkem House, Senapati Bapat Marg, Lower Parel, Mumbai Maharashtra- 400013

Country of origin: INDIA

References

Tofacitinib: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a613025.html
Padda, I. S., Bhatt, R., & Parmar, M. (2023). Tofacitinib. StatPearls - NCBI Bookshelf. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK572148/
Tofacitinib: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB08895
Dhillon, S. (2017). Tofacitinib: A Review in Rheumatoid Arthritis. Drugs, 77(18), 1987-2001. https://pubmed.ncbi.nlm.nih.gov/29139090/
Vardanyan, R. (2017). 3-Substituted and 1,3-Disubstituted piperidines. In Elsevier eBooks (pp. 127–146). https://doi.org/10.1016/b978-0-12-805157-3.00004-1

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