Tofza 5mg Tablet 14

Tofza Tablet 14

Wallace Pharmaceuticals Ltd.

Strip of 14 Units

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Composition

Tofacitinib (5 Mg)

Tofza Tablet is primarily utilised to manage moderate to severe rheumatoid arthritis in adults. This medicine falls under the category of Janus kinase (JAK) inhibitors.

Apart from its primary use, this tablet can also help manage active psoriatic arthritis, moderately to severely active ulcerative colitis, and active ankylosing spondylitis in adults. These conditions can be managed with this tablet alone or in combination with other medicines like methotrexate.

Before you start on this medicine, it's vital to have a detailed consultation with your doctor about the exact dosage and frequency. Make sure you inform your doctor about any pre-existing diseases or ongoing medication before beginning this medicine. If you notice any side effects while on this medication, notify your doctor straight away. To see optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Tofza Tablet is used for the following:

Management of moderate to severe rheumatoid arthritis in adults unresponsive or intolerant to methotrexate
Control of active psoriatic arthritis in adults
Reducing symptoms of moderately to severely active ulcerative colitis in adults who have not responded well or are intolerant to TNF blockers
Management of active ankylosing spondylitis in adults unresponsive or intolerant to TNF blockers

Here's how you should go about taking Tofza Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Follow your doctor's instructions on when and how frequently to take the medicine.
Do not stop taking this medicine without consulting your doctor first.

Tofza Tablet is taken orally.

Tofza Tablet may cause the following side effects:

Upper respiratory tract infections: This can include symptoms like a cough, sore throat, or runny nose.
Headache
Diarrhoea
Nasopharyngitis: This is an infection that causes inflammation of the nose and throat.
Some uncommon but serious side effects include:
Blood clots in the lungs or legs
Tears in the stomach or intestines
Liver enzyme elevations: This could mean your liver isn't working as well as it should.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Tofza Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips for managing common side effects:

Diarrhoea: You could try taking your Tofza Tablet with meals to reduce this effect.
Headache: If this medicine is causing you headaches, consider taking it at bedtime.

Tofza Tablet contains tofacitinib (5 mg) which acts on your body in the following ways:

Selective Inhibition of JAK Enzymes: Tofacitinib selectively blocks JAK enzymes, specifically JAK1 and JAK3. These enzymes play a pivotal role in inflammation.
Reduction of Inflammation: By blocking the pathways of these enzymes, Tofacitinib effectively reduces inflammation in the body. This helps decrease symptoms like joint pain, swelling and stiffness associated with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It can also reduce intestinal inflammation in cases of ulcerative colitis.

Pregnancy

Tofza Tablet is not recommended during pregnancy. It may cause harm to the unborn baby. If you are pregnant or planning to conceive, it is best to discuss this with your doctor before using this medicine.

Breastfeeding

Avoid breastfeeding while taking Tofza Tablet. Consult your doctor to understand the potential risks and benefits.

Alcohol

There is no specific interaction between Tofza Tablet and alcohol. However, you should always consult your doctor for advice on consuming alcohol whilst taking any medication.

Liver

Tofza Tablet needs caution if you have liver conditions. It is advised to discuss liver-related concerns with your doctor before starting treatment with this medicine. They will evaluate if this medicine is suitable for you.

Kidney

Caution is advised when using Tofza Tablet if you have a history of kidney health issues. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

There is no known effect of Tofza Tablet on driving or operating machinery. However, do not drive or operate machinery if you feel unwell or unable to concentrate.

Allergy

Do not take Tofza Tablet if you are allergic to tofacitinib or any other ingredients in the formulation. If you experience any allergic reactions like rash, shortness of breath, swelling and itching, contact your doctor immediately.

Children

Tofza Tablet is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

If you are an older patient, take Tofza Tablet under medical supervision as you may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Tofza Tablet interacts with the following medicines:

CYP3A4 inhibitors: Medicines like ketoconazole interact with Tofza Tablet, potentially requiring dosage adjustments due to their effects on liver enzyme activity.
CYP3A4 inducers: Medications such as rifampin could reduce the effectiveness of Tofza Tablet by inducing liver enzymes that metabolise the medicine.
Hormonal contraceptives: The effectiveness of hormonal contraceptives like birth control pills may decrease when taken alongside Tofza Tablet.
JAK inhibitors and biologic DMARDs: Combining other JAK inhibitors or biologic disease-modifying antirheumatic drugs (DMARDs) with Tofza Tablet could lead to excessive immunosuppression.
Potent immunosuppressants: Medications like azathioprine and cyclosporine when taken with Tofza Tablet may increase the risk of added immunosuppression.

Drug-Food Interactions

No specific known food interactions exist with Tofza Tablet. You can take it with or without food, as per your convenience and preference.

Drug-Disease Interactions

Tofza Tablet interacts with the following diseases:

Active, serious infections: Infections, even localized ones, can worsen if you take Tofza Tablet when you are seriously ill.
Chronic lung disease: Given that Tofza Tablet can lead to serious infections due to immunosuppression, it should be used cautiously in patients with chronic lung disease.
History of blood clots: This medication might increase your risk of blood clots if you have a history of this health condition.

Daily Dose

The daily dose of Tofza Tablet should be taken as directed by your doctor. Your doctor might tweak the dosage depending on the severity of your condition and how you respond to the medicine. Always adhere to the prescribed dosage and refrain from exceeding it without consulting your doctor.

Over Dose

Overdosing on Tofza Tablet could lead to common symptoms like upper respiratory tract infections, headache, and diarrhoea. If you've taken more than your prescribed dose, don't panic but do inform your doctor so they can advise you on the next steps.

Missed Dose

If you've missed a dose of Tofza Tablet, take it as soon as you remember. However, if your next dose is due soon, skip the missed one and continue with your regular schedule. Don't increase your dose without consulting your doctor.

Store Tofza Tablet in a cool and dry place, ideally at a temperature below 30°C.
Keep it away from direct light and moisture to maintain its effectiveness.
Always keep this medicine out of the reach of children.
Do not use Tofza Tablet beyond its expiry date.

If you have rheumatoid arthritis or psoriatic arthritis, try to incorporate more omega-3 fatty acids into your diet. Foods rich in these include fish, walnuts, and flaxseeds; they can help reduce inflammation.
For individuals with ulcerative colitis, maintaining hydration is important. Ensure to drink plenty of fluids throughout the day, particularly if symptoms such as diarrhoea are present.

Fact Box

Drug Category	Janus Kinase Inhibitor
Therapeutic Category	Anti Inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis

What is Tofza Tablet used for?

Tofza Tablet is used to manage conditions like rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis in adults.

How does Tofza Tablet work?

It works by blocking specific enzymes (JAK1 and JAK3) involved in the inflammation process, thus reducing symptoms like joint pain and swelling.

Is Tofza Tablet a biologic medicine?

No, it isn't a biologic. Tofza Tablet is a targeted synthetic medicine that suppresses the immune system differently than biologics.

Can I take other medicines while using Tofza Tablet?

Yes, but some medications may interact with Tofza Tablet. Always consult your doctor before starting any new medicine.

Is it safe to use Tofza Tablet during pregnancy or while breastfeeding?

It's not recommended to use Tofza Tablet during pregnancy or while breastfeeding. Consult your doctor for safer alternatives.

What should I do if I miss a dose of Tofza Tablet?

If you miss a dose, take it as soon as you remember unless it's nearly time for the next one. Never double up on doses.

How should I store my Tofza Tablets?

Store them below 30°C, protect from light and moisture, and keep out of reach of children.

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 5 years

MD Ayurveda

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

T1/B NATIONAL PARKGULBAI TEKRA AHMEDABAD GJ 380015 IN

Country of origin: INDIA

References

Pfizer, Inc. (2018). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
Tofacitinib: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB08895
Qian, J., Xue, X., & Shannon, J. (2022). Characteristics of adverse event reporting of Xeljanz/Xeljanz XR, Olumiant, and Rinvoq to the US Food and Drug Administration. Journal of Managed Care & Specialty Pharmacy, 28(9), 1046–1052. https://doi.org/10.18553/jmcp.2022.28.9.1046
Padda, I. S., Bhatt, R., & Parmar, M. (2023, July 3). Tofacitinib. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK572148/

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