Zolmist Nasal Spray 7mdi

Cipla Ltd.

Bottle of 7 MDI

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MRP ~~₹786.55~~

₹629.24

₹112.36/MDI

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Composition

Zolmitriptan (5 Mg)

Zolmist Nasal Spray is primarily used to manage acute migraine headaches in adults, with or without aura. It belongs to a category of medicines known as 5-HT1B/1D receptor agonists.

In addition to its main use, this nasal spray also helps in inhibiting the release of pro-inflammatory neuropeptides, leading to cranial vessel constriction. However, it's important to remember that it does not prevent future migraines or reduce the frequency of attacks.

Before using this medicine, consult your doctor to understand the appropriate dosage and frequency for your specific condition. It would be beneficial to inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you experience any side effects, promptly notify your doctor. For optimal results, continue using the medicine for the duration your doctor prescribes.

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Zolmist Nasal Spray is used for the following:

Providing relief during acute migraine attacks with aura: Aura refers to specific warning signs, such as visual disturbances that occur just before the onset of a migraine.
Alleviating symptoms during acute migraine attacks without aura: An attack without aura is a migraine that comes on suddenly without any preceding signs.

Directions for Use of Zolmist Nasal Spray 7mdi

To use Zolmist Nasal Spray effectively, follow these steps:

Clear your nose gently before using the spray.
Close one nostril by pressing gently against the side of your nose.
Place the tip of the spray device into the other nostril.
Breathe gently through your nose as you press down on the plunger to release the spray.
After administering the spray, keep your head tilted back slightly and breathe softly through your mouth for 5 to 10 seconds.

Zolmist Nasal Spray is administered via the intranasal route.

Side Effects of Zolmist Nasal Spray 7mdi

Zolmist Nasal Spray may have the following common side effects:

Unusual taste
Paresthesia: This refers to abnormal sensations on the skin such as tingling or pricking ("pins and needles").
Dizziness
Hyperesthesia: This is an increased sensitivity to stimuli, such as touch or pain.
Neck pain/tightness/pressure/heaviness
Somnolence: It means feeling drowsy or sleepy.
Nausea
Throat pain/tightness/pressure

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Zolmist Nasal Spray. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Unusual taste: To manage this, you could rinse your mouth with water after using the nasal spray.
Dizziness: If you experience dizziness, try lying down or sitting still until it passes.

Zolmist Nasal Spray contains Zolmitriptan (5 mg), which works on your body as follows:

Cranial Vessel Constriction: Zolmitriptan binds with high affinity to human 5-HT1D and 5-HT1B receptors located on intracranial blood vessels. This action leads to the constriction of these vessels, which helps in providing relief during a migraine attack.
Inhibition of Pro-Inflammatory Neuropeptide Release: Zolmitriptan also inhibits the release of pro-inflammatory neuropeptides from sensory nerve endings. These neuropeptides are involved in pain transmission and their inhibition helps in managing the pain associated with migraines.
Affecting Certain Nerves in the Brain: Zolmitriptan may relieve pain by affecting certain nerves in the brain, thus aiding in the management of acute migraines.

Pregnancy

Caution is advised while using Zolmist Nasal Spray if you are pregnant. Always consult your doctor before taking this medicine.

Breastfeeding

Zolmist Nasal Spray should be used with caution if you are breastfeeding. It's best to discuss it with your doctor first.

Alcohol

There's no interaction between Zolmist Nasal Spray and alcohol. However, it's always wise to consult your doctor about potential risks.

Liver

The effect of liver impairment on the use of Zolmist Nasal Spray has not been evaluated. If you have liver problems, you are advised to consult your doctor before starting this medicine.

Kidney

If you have a history of kidney issues, consult your doctor before using Zolmist Nasal Spray.

Using Machines & Driving

Zolmist Nasal Spray may cause dizziness or sleepiness in some people. If you experience these symptoms, avoid driving or operating machinery until you feel well enough.

Allergy

Avoid using it if you are allergic to zolmitriptan or any other ingredients in Zolmist Nasal Spray. Always inform your doctor about any allergies.

Children

Zolmist Nasal Spray is not recommended for use in children as its safety and effectiveness have not been established in this age group. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Zolmist Nasal Spray under medical supervision as they might be more sensitive to its effects. If you're above 70 years of age or have liver and kidney issues, your doctor will guide you based on your health status.

Interactions of Zolmist Nasal Spray 7mdi

Drug-Drug Interactions

Zolmist Nasal Spray interacts with the following medicines:

Ergot-containing medications: These medicines, such as ergotamine and methysergide, can increase the risk of vasospastic reactions when taken with Zolmist Nasal Spray.
5-HT1B/1D agonists: Medicines like sumatriptan and rizatriptan may have additive effects, potentially leading to an increased risk of side effects.
MAO-A inhibitors: Medicines like phenelzine and isocarboxazid can increase zolmitriptan levels in your blood when used concurrently with Zolmist Nasal Spray.
H₂ receptor antagonist: Medications like cimetidine inhibit the metabolism of zolmitriptan, resulting in a rise in its plasma levels when taken with Zolmist Nasal Spray.

Drug-Food Interactions

There are no specific known food interactions with Zolmist Nasal Spray.

Drug-Disease Interactions

Zolmist Nasal Spray interacts with the following diseases:

Ischemic Heart Disease or Coronary Artery Vasospasm: Using Zolmist Nasal Spray can worsen these conditions due to its vasoconstrictive effects.
Uncontrolled Hypertension: This medicine can increase blood pressure levels, which could complicate hypertension management.
Hemiplegic or Basilar Migraine: Zolmist Nasal Spray is not recommended for individuals suffering from these types of migraines.
Liver impairment: As the effect of liver impairment on Zolmist Nasal Spray has not been evaluated, it should be used cautiously in these patients.

Daily Dose

The daily dose of Zolmist Nasal Spray should be administered as instructed by your doctor. The dosage may vary based on individual factors, such as the severity of your condition and response to the medication. Always follow your doctor's prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

If you accidentally use more than the recommended dose of Zolmist Nasal Spray, you might experience side effects such as dizziness, sleepiness, or an unusual taste in the mouth. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you miss a dose of Zolmist Nasal Spray, administer it as soon as you remember. If it is nearly time for your next dose, skip the missed one and return to your regular dosage schedule. Never increase your dosage without consulting your doctor.

Keep Zolmist Nasal Spray stored under 25°C.
Protect this medicine from light and moisture.
Ensure that the product is out of reach of children.
Use the nasal spray before its expiry date.

Certain foods can trigger migraines, so try to identify and avoid them. Common culprits include aged cheese, chocolate, and foods containing monosodium glutamate (MSG).
Since stress is a known migraine trigger, practise stress management techniques such as yoga or deep-breathing exercises to help manage your migraine symptoms. Consult your doctor for more personalised advice.

Fact Box

Drug Category	5-HT1B/1D Agonist
Therapeutic Category	Antimigraine
Available Dosage Types	Nasal Spray
Habit Forming	No
Ailment	Migraine with aura, Migraine without aura

What is Zolmist Nasal Spray used for?

Zolmist Nasal Spray is used to manage acute migraines with or without aura in adults. It helps diminish the severity of migraine headaches.

How does Zolmist Nasal Spray work?

It contains zolmitriptan, which narrows blood vessels in the brain, reducing the pain caused by migraines. However, it doesn't prevent future migraines.

Can I use Zolmist Nasal Spray to prevent migraines?

No, Zolmist Nasal Spray isn't designed to prevent migraines. It is intended only for managing acute migraine attacks as and when they occur.

When should I use Zolmist Nasal Spray?

You should use it at the first sign of a migraine attack. The medicine manages the symptoms of an ongoing migraine but doesn't prevent them.

Are there any side effects associated with Zolmist Nasal Spray?

Common side effects include unusual taste, dizziness, neck pain, and nausea. If you experience these or other adverse effects, consult your doctor immediately.

Can I use other migraine medications with Zolmist Nasal Spray?

Consult your doctor before combining other medications with Zolmist Nasal Spray, as certain combinations can lead to harmful interactions, such as an increased risk of serotonin syndrome.

How should I store my Zolmist Nasal Spray?

Store your spray under 25°C, away from light and moisture. After use, ensure you discard the device properly.

Last Updated On 23 Dec. 2024 | 10:53AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

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Manufacturer details

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: INDIA

References

MedlinePlus. (n.d.). Zolmitriptan: MedlinePlus Drug Information. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a605046.html
U.S. Food and Drug Administration. (2003). ZOMIG (zolmitriptan) Nasal Spray Label. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21450_zomig_lbl.pdf
Zolmitriptan. (2024, October 10). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00315

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