Amlodipine + Losartan
Uses of Amlodipine + Losartan
Amlodipine + Losartan is primarily used to manage high blood pressure in adults who have not responded adequately to monotherapy with either amlodipine or losartan. It is a combination of two types of medications, namely a calcium channel blocker and an angiotensin II receptor blocker.
Additionally, Losartan, one of the active ingredients in this combination, is indicated for reducing the risk of stroke in patients with high blood pressure and left ventricular hypertrophy (thickening of the heart muscle of the left ventricle).
Side effects of Amlodipine + Losartan
Dizziness
Lightheadedness (sensation of fainting)
Fatigue
Peripheral oedema (swelling in the legs, ankles or feet)
Nasal congestion
How Amlodipine + Losartan works
Amlodipine + Losartan is an antihypertensive combination medication.
Amlodipine is a calcium channel blocker. It works by obstructing calcium's movement into your blood vessels' muscle cells. This makes the vessels relax and widen, which helps decrease your blood pressure and makes it easier for your heart to pump blood.
Losartan is an angiotensin II receptor blocker (ARB). It works by obstructing the effects of a natural substance called angiotensin II, which tightens blood vessels. This helps the vessels relax and widen, lowering blood pressure.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Amlodipine + Losartan is available via the oral route in the form of tablets.
Age and Dose Restrictions
This combination is primarily meant for adults. The safety and effectiveness of Amlodipine + Losartan in children have not been established.
Contraindications
Amlodipine + Losartan is contraindicated in patients with known hypersensitivity to either component of the medicine. It should not be used by patients with severe hepatic impairment, severe renal impairment, or bilateral renal artery stenosis (a condition that occurs when one or both of the renal arteries narrow).
Other Medications to Avoid
Amlodipine + Losartan may interact with other blood pressure treating medicines (e.g., lisinopril, ramipril), pain killers (e.g., aspirin, ibuprofen) and heart-related medicines (e.g., metoprolol, nitroglycerin).
Overdose and Missed Dose
An overdose of Amlodipine + Losartan may result in low blood pressure, palpitations (abnormal heart rhythm), or potentially serious kidney problems. If an overdose is suspected, immediate medical attention should be sought.
If a dose is missed, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regularly scheduled time. Do not double the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For dizziness and lightheadedness, try to stand up slowly from a sitting or lying position.
Use in Driving and Operating Machinery
Amlodipine + Losartan may cause dizziness or lightheadedness. Avoid driving or operating heavy machinery if you experience these symptoms after taking the medication.
Use in Pregnancy and Lactation
Amlodipine + Losartan is not recommended for use during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medication.
Caution in Other Conditions
Patients with heart failure or severe aortic stenosis (a heart condition that occurs when the aortic valve narrows, thickens, or stiffens), hyperkalaemia (high potassium levels in the blood) and diabetes should also exercise caution when taking this medication.
Special Dietary and Lifestyle Recommendations
Maintain a low-sodium diet to help lower your blood pressure.
Limit alcohol intake as it can raise your blood pressure and increase the side effects of this medication.
Frequently asked questions
Is Amlodipine + Losartan a steroid?
No, Amlodipine + Losartan is not a steroid. It is a combination of two different types of blood pressure medicines. Amlodipine is a calcium channel blocker and Losartan is an angiotensin II receptor blocker.
Does the Amlodipine + Losartan have any effect on sleep?
Amlodipine + Losartan is not typically known to affect sleep. However, some people may experience side effects such as dizziness or fatigue which may indirectly influence their sleep patterns. Always consult your doctor if you notice any unusual symptoms.
Will Amlodipine + Losartan affect fertility?
There is currently no evidence to suggest that Amlodipine + Losartan has an impact on fertility. However, if you are planning to conceive or are having difficulties in conceiving, it is best to consult your doctor.
Is it safe to take Amlodipine + Losartan daily?
The dosage and frequency of Amlodipine + Losartan should be followed as prescribed by your doctor.
How much time does Amlodipine + Losartan take to work?
Amlodipine + Losartan starts working within a few hours of taking the tablet. However, it may take up to three weeks for your blood pressure to be fully controlled.
What is the best time to take Amlodipine + Losartan?
Amlodipine + Losartan can be taken at any time of the day. However, it's best to take it at the same time each day as this helps to maintain a stable level of the medicine in your body.
Does Amlodipine + Losartan cause weight gain?
There is no scientific evidence to suggest that Amlodipine + Losartan directly leads to weight gain. However, if you observe any unusual changes in your weight after starting the medicine, consult your doctor.
Amlodipine + Losartan in other salts
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