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Carbidopa + Entacapone + Levodopa

Uses of Carbidopa + Entacapone + Levodopa

  • Carbidopa + Entacapone + Levodopa is used to manage symptoms of Parkinson's disease such as shakiness, stiffness, and difficulty moving. The combination belongs to a group of medications known as dopaminergic anti parkinsonism agents.

Side effects of Carbidopa + Entacapone + Levodopa

  • Nausea

  • Vomiting

  • Dizziness

  • Abnormal dreams

  • Involuntary movements

How Carbidopa + Entacapone + Levodopa works

  • Carbidopa + Entacapone + Levodopa is a combination medicine for Parkinson's disease management.

  • Levodopa, one of the components, is converted into dopamine in the brain. Dopamine is a key substance that helps regulate muscle movement.

  • Carbidopa prevents Levodopa from breaking down before it can reach the brain, which means more Levodopa enters the brain to be converted into dopamine. This also reduces side effects such as nausea.

  • The third component, Entacapone, belongs to a class of medicines known as COMT inhibitors. It further prevents the breakdown of Levodopa, maintaining higher and more stable levels of this substance in the blood.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Carbidopa + Entacapone + Levodopa combination is available as oral tablets. This medication is designed to be taken via the mouth, simplifying the administration process.

Age and Dose Restrictions

  • This medicine is intended for use in adults. It is not typically recommended for children or adolescents, as the safety and efficacy have not been established in these age groups.

Contraindications

  • Carbidopa + Entacapone + Levodopa should not be taken by patients with known hypersensitivity to any of the ingredients in this combination.

  • It is contraindicated in patients with Narrow-angle glaucoma, suspicious skin lesions or a history of melanoma or pheochromocytoma, and those taking non-selective MAO inhibitors.

Other Medications to Avoid

  • This combination may interact with non-selective MAO inhibitors (such as phenelzine and tranylcypromine), antihypertensives (like metoprolol and lisinopril), antipsychotics (like risperidone and clozapine), tricyclic antidepressants (like amitriptyline and nortriptyline) and medicines like isoniazid and phenytoin which can alter Levodopa bioavailability.

  • Doctors should be consulted before starting any other prescription or over-the-counter medications concurrently with this combination.

Overdose and Missed Dose

  • An overdose of Carbidopa + Entacapone + Levodopa may lead to severe nausea, vomiting, irregular heartbeat, muscle stiffness and unconsciousness. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. But if it is close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking adequate water may help manage some gastrointestinal side effects like nausea and diarrhoea.

  • For dizziness or lightheadedness, it is suggested to rise gradually from a seated or lying position.

Use in Driving and Operating Machinery

  • Carbidopa + Entacapone + Levodopa may cause dizziness or drowsiness, affecting the ability to drive or operate heavy machinery. Caution is advised until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • Carbidopa + Entacapone + Levodopa should be used with caution during pregnancy and breastfeeding. Always consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Patients with severe cardiovascular or pulmonary disease, peptic ulcer, hepatic or renal impairment, endocrine diseases like hyperthyroidism, and a history of seizures or psychosis should exercise caution when taking Carbidopa + Entacapone + Levodopa.

Special Dietary and Lifestyle Recommendations

  • A balanced diet rich in fruits, vegetables, lean proteins and healthy fats can contribute to overall health and wellbeing, supporting optimal treatment outcomes.

  • Regular physical activity can help improve mood and energy levels. It can also help maintain a healthy weight.

  • It is important to get adequate rest to support overall health and well-being.

  • Avoid excessive intake of protein-rich foods as they may interfere with the absorption of Levodopa.

Frequently asked questions

No, Carbidopa + Entacapone + Levodopa is not a steroid. It is a combination medication used to manage Parkinson's disease.

Yes, some patients may experience mood changes such as depression as a side effect of Carbidopa + Entacapone + Levodopa. If you notice a significant change in your mood or behaviour, consult your doctor immediately.

Carbidopa + Entacapone + Levodopa may interact with iron salts and reduce the absorption of Levodopa. It is advisable to take this medicine at least 2 hours apart from your iron supplement.

There are several medicines available for managing Parkinson's disease. However, the choice of medicine depends on various factors, and only your doctor can determine the most appropriate alternative to Carbidopa + Entacapone + Levodopa for you.

Never stop taking Carbidopa + Entacapone + Levodopa without discussing it with your doctor. Abrupt discontinuation can lead to severe withdrawal symptoms.

Yes, consuming high-protein foods can reduce the absorption of Levodopa, affecting the effectiveness of Carbidopa + Entacapone + Levodopa. It is advisable to follow a balanced diet and maintain regular meal timings while taking this medicine.

While certain dietary supplements and herbal remedies are promoted for Parkinson's disease, none have been proven to be as effective as prescription medications like Carbidopa + Entacapone + Levodopa. Always consult your doctor before trying any natural alternatives.

Terms & Conditions


Carbidopa + Entacapone + Levodopa in other salts

Available medicines for CARBIDOPA + ENTACAPONE + LEVODOPA
Tidomet E 50/12.5/200 MG Tablet 10
Tidomet E 50/12.5/200 MG Tablet 10
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Pack of 10 Units
₹39.61
MRP ₹48.30
18.00% OFF
Syncapone 50 Tablet 10
Syncapone 50 Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹90.20
MRP ₹110.00
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Syncapone 150 Tablet 10
Syncapone 150 Tablet 10
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₹121.36
MRP ₹148.00
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Syncapone 100 Tablet 10
Syncapone 100 Tablet 10
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Pack of 10 Units
₹114.80
MRP ₹140.00
18.00% OFF
Entacom Plus 100 Tablet 10
Entacom Plus 100 Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹112.75
MRP ₹137.50
18.00% OFF
Entacom-plus 50/12.5/200 MG Tablet 10
Entacom-plus 50/12.5/200 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹61.50
MRP ₹75.00
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Elcapon 100 MG Tablet 10
Elcapon 100 MG Tablet 10
Zydus Cadila
Pack of 10 Units
₹49.20
MRP ₹60.00
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Entacom Plus 150 Tablet 10
Entacom Plus 150 Tablet 10
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₹128.94
MRP ₹157.25
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