Dapagliflozin + Sitagliptin
Uses of Dapagliflozin + Sitagliptin
Dapagliflozin + Sitagliptin is a combination medication used primarily for the management of type 2 diabetes mellitus in adults. It is part of the group of diabetes medications.
This medication may also help reduce the risk of hospitalisation for heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.
Side effects of Dapagliflozin + Sitagliptin
Genital yeast infections
Urinary tract infections
Nasopharyngitis
Upper respiratory tract infections
Headache
How Dapagliflozin + Sitagliptin works
Dapagliflozin is a medicine for managing type 2 diabetes. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It functions by preventing the kidneys from reabsorbing glucose back into the bloodstream. Instead, this glucose gets eliminated through urine, thus reducing the amount of sugar in the blood.
Sitagliptin is a medicine for managing type 2 diabetes. It is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It prevents the breakdown of incretin hormones, which are chemicals that stimulate insulin production in the pancreas. This leads to an increase in insulin, a hormone that helps lower blood sugar levels, especially after meals.
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Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Dapagliflozin + Sitagliptin can be taken orally (tablet).
Age and Dose Restrictions
This combination medicine is intended for adults only.
Contraindications
Dapagliflozin + Sitagliptin is contraindicated in patients with a history of severe allergies to either dapagliflozin or sitagliptin. It is also contraindicated for patients with type 1 diabetes and severe kidney impairment.
Other Medications to Avoid
This combination may interact with diuretics (e.g., furosemide, hydrochlorothiazide), insulin or sulfonylureas (e.g., glipizide, glyburide), and certain antibiotics (e.g., rifampin).
Overdose and Missed Dose
An overdose of Dapagliflozin + Sitagliptin can lead to symptoms such as nausea, vomiting, stomach pain, tiredness, and trouble breathing. If you suspect an overdose, contact your doctor immediately.
If you forget a dose of Dapagliflozin + Sitagliptin, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage increased urination and reduce the risk of dehydration.
Maintaining good personal hygiene practices can help reduce the risk of genital yeast infections and urinary tract infections.
Use in Driving and Operating Machinery
Dapagliflozin + Sitagliptin may cause dizziness or lightheadedness. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough.
Use in Pregnancy and Lactation
The use of Dapagliflozin + Sitagliptin in pregnancy and lactation is not recommended. Always consult your doctor before using this medicine during these times.
Caution in Other Conditions
Patients with a history of pancreatitis should exercise caution when taking Dapagliflozin + Sitagliptin. Regular monitoring of kidney function is necessary while taking this medication, especially in patients with kidney disease.
Special Dietary and Lifestyle Recommendations
Limit your intake of sugary drinks and high-fat foods, which can lead to poor blood sugar control.
Regular monitoring of your blood sugar levels can help you understand how food, physical activity, and stress affect your diabetes.
Frequently asked questions
Does Dapagliflozin + Sitagliptin have any effect on menstrual cycles?
Dapagliflozin + Sitagliptin does not affect menstrual cycles. However, if you notice any unusual changes in your menstrual cycle while taking this medicine, consult your doctor.
Can Dapagliflozin + Sitagliptin affect my mood?
If you notice significant mood changes or become depressed while taking Dapagliflozin + Sitagliptin, inform your doctor immediately. While not typically associated with mood changes, everyone's response to medication can vary.
Is it safe to take Dapagliflozin + Sitagliptin with alcohol?
Patients taking Dapagliflozin + Sitagliptin are advised to avoid excessive alcohol intake as it may increase the risk of ketoacidosis - a serious condition where the body starts breaking down fat at a rate that is much too fast.
Is Dapagliflozin + Sitagliptin a vegetarian/vegan-friendly medicine?
It would be best to consult your doctor or the manufacturer for details about the source of the ingredients.
Can I stop taking Dapagliflozin + Sitagliptin if I feel better?
No, you should not stop taking Dapagliflozin + Sitagliptin without consulting your doctor. Your symptoms may improve before your condition is completely treated.
Are there any natural alternatives to Dapagliflozin + Sitagliptin?
While maintaining a healthy diet and regular exercise are crucial for managing type 2 diabetes, they cannot replace your prescribed medication. There are no natural alternatives that have been proven to have the same efficacy as Dapagliflozin + Sitagliptin.
Does Dapagliflozin + Sitagliptin cause weight gain?
No, Dapagliflozin + Sitagliptin can actually lead to modest weight loss due to its mechanism of action.
Dapagliflozin + Sitagliptin in other salts
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