Desmopressin

Dosage Forms Available

• Desmopressin can be instilled nasally (spray), taken orally (tablet or sublingual tablet) and administered subcutaneously or intravenously (injection).

Age and Dose Restrictions

• Desmopressin is intended for use in adults and children over 6 years old.

Contraindications

• Desmopressin is contraindicated in patients with known hypersensitivity to it.

• It's also not recommended for those with severe kidney impairment, hyponatremia or a history of hyponatremia. Patients with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), Type IIB or platelet-type von Willebrand disease or polydipsia (excessive thirst) or psychogenic water intoxication should not take Desmopressin.

Other Medications to Avoid

• Desmopressin may interact with medications that can cause fluid retention or hyponatremia, such as tricyclic antidepressants (like amitriptyline and imipramine), selective serotonin reuptake inhibitors (like fluoxetine and sertraline), and NSAIDs (like ibuprofen and naproxen).

Overdose and Missed Dose

• An overdose of Desmopressin can lead to symptoms of hyponatremia, such as nausea, headache, confusion, seizures and even loss of consciousness. If you exhibit any of these symptoms, seek immediate medical assistance.

• If you miss a dose of Desmopressin, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed one and continue with your regular schedule. Never take an extra dose to compensate for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience mild abdominal cramps or nausea, try taking Desmopressin after meals.

• Should you experience flushing of the face, try to stay in a cool environment and avoid overheating.

• For nasal congestion or nosebleeds resulting from the use of Desmopressin nasal spray, saline nasal sprays may help keep your nasal passages moist and comfortable.

Use in Driving and Operating Machinery

• Desmopressin does not usually affect your ability to drive or operate machinery. However, if you feel dizzy or unwell after taking this medication, do not drive or operate heavy machinery.

Use in Pregnancy and Lactation

• Desmopressin should only be used during pregnancy if the benefits outweigh the potential risks. You should discuss this with your doctor before starting treatment. It may be safe to use Desmopressin while breastfeeding but consult your doctor first.

Caution in Other Conditions

• Patients with heart failure, kidney disorders or uncontrolled hypertension should use Desmopressin with caution as fluid retention can worsen these conditions.

Special Dietary and Lifestyle Recommendations

• For patients taking Desmopressin for nocturia (frequent nighttime urination), it may help to avoid drinking large amounts of fluids in the evening.

• For patients with central diabetes insipidus (CDI), a balanced diet that includes adequate amounts of sodium can help manage symptoms.