Medroxyprogesterone
Uses of Medroxyprogesterone
Medroxyprogesterone is primarily used for a range of conditions related to the female reproductive system. These include amenorrhoea (absence of menstruation), abnormal uterine bleeding, and endometriosis (a condition in which tissue that usually lines the uterus grows outside the uterus). It belongs to the group of medicines known as progestins.
In addition, it can also be used as a contraceptive to prevent pregnancy and as an adjunctive and palliative treatment for inoperable, recurrent, and/or metastatic endometrial cancer.
Side effects of Medroxyprogesterone
Breast tenderness
Headache
Nausea and vomiting
Irregular vaginal bleeding or spotting
Mood changes
How Medroxyprogesterone works
Medroxyprogesterone is a type of progestin, which is a synthetic form of the naturally occurring hormone progesterone.
It works by replacing the normal functions of progesterone in the body. This means it assists in various processes such as regulating menstrual cycles and maintaining pregnancy.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Medroxyprogesterone can be taken orally (tablet) and intramuscularly and subcutaneously (injection).
Age and Dose Restrictions
- Medroxyprogesterone is intended for use in adults aged 18 and above.
Contraindications
- Medroxyprogesterone is contraindicated in patients with undiagnosed vaginal bleeding, as it may exacerbate the condition. It must not be used by individuals with known hypersensitivity to Medroxyprogesterone or any of its components.
Other Medications to Avoid
- Medroxyprogesterone may interact with specific enzyme-inducing antiepileptic medicines (such as carbamazepine and phenobarbital, and phenytoin), antifungal agents (like fluconazole and itraconazole), and certain herbal products (such as St. John's wort).
Overdose and Missed Dose
- An overdose of Medroxyprogesterone may lead to nausea, vomiting, and dizziness. In such situations, immediate medical attention should be sought.
- If a dose is missed, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double up the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of fluids can help manage headaches.
- For nausea and vomiting, try administering this medicine with food.
Use in Driving and Operating Machinery
- Medroxyprogesterone may cause dizziness or fatigue. If you experience these symptoms, it is advised not to drive or operate heavy machinery until you feel alert again.
Use in Pregnancy and Lactation
- Medroxyprogesterone is not advised during pregnancy unless clearly necessary and only after consultation with your doctor.
- It should be used with caution during breastfeeding. Consult your doctor before using this medicine if you are breastfeeding.
Caution in Other Conditions
- Patients with a history of depression, a history of thromboembolic disorders or strokes should use Medroxyprogesterone with caution as it may worsen their condition.
Special Dietary and Lifestyle Recommendations
- Limit the intake of processed foods and those high in sugar or saturated fats to manage potential weight gain due to Medroxyprogesterone use.
- Regular check-ups are recommended to monitor your health while using Medroxyprogesterone.
Frequently asked questions
Is Medroxyprogesterone a steroid?
Yes, Medroxyprogesterone is a form of steroid. More specifically, it is a synthetic form of a female hormone known as progesterone.
Does Medroxyprogesterone have any effect on sleep?
While some patients administering Medroxyprogesterone might experience changes in sleep patterns, this is not a common side effect. However, it can cause mood changes, including depression and irritability, which could indirectly affect sleep.
Can Medroxyprogesterone affect fertility?
Yes, one of the primary uses of Medroxyprogesterone is as a contraceptive to prevent pregnancy. It works by preventing ovulation and thickening the cervical mucus, making it difficult for sperm to enter the uterus.
Is it safe to administer Medroxyprogesterone daily?
Yes, it is safe to administer Medroxyprogesterone daily if prescribed by your doctor. However, the dose and duration of treatment would depend on the specific condition being treated and the patient's response.
How much time does Medroxyprogesterone take to work?
The time taken for Medroxyprogesterone to work can vary depending on the condition being managed. It is important to follow the doctor's instructions and continue taking the medication even if you feel well.
What is the best time to administer Medroxyprogesterone?
Medroxyprogesterone can be administered at any time that suits you best but try to administer it at the same time each day for better results. It can be administered with or without food.
Can Medroxyprogesterone be used by men?
While primarily prescribed for conditions related to the female reproductive system, Medroxyprogesterone may also be prescribed for men in certain specific circumstances under medical supervision. Consult your doctor for more advice.
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