Home/Drugs By Ailments / Methotrexate

Methotrexate

ANTI-METABOLITES / IMMUNOSUPPRESSANTS

Uses of Methotrexate

  • Methotrexate treats inflammatory conditions like rheumatoid arthritis and psoriasis. It works by reducing inflammation, helping to relieve pain and prevent long-term damage to joints and skin.

Side effects of Methotrexate

  • Abdominal Pain 
  • Indigestion 
  • Loss of Appetite 
  • Nausea 
  • Vomiting 
  • Tiredness 
  • Mouth Sore 
  • Stomatitis 
  • Low Blood Platelets 
  • Pneumonitis 
  • Exanthema 
  • Erythema 
  • Decreased White Blood Cell Count 
  • Increased Liver Enzymes

How Methotrexate works

  • Methotrexate falls under the Immunosuppressant agent category. It is effective in the treatment of rheumatoid arthritis by reducing the activity of the immune system in the body. It results in a reduction in oedema, as well as a reduction of pain and stiffness, and an improvement in function. In psoriasis, it acts by inhibiting the fast proliferation of skin cells.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Doctors recommend Methotrexate for the therapy of autoimmune conditions such as rheumatoid arthritis and psoriasis. The effectiveness of Methotrexate is not usually seen until after 6 to 8 weeks have passed. Take it as directed every day. It is recommended that Methotrexate be taken once weekly at the same time each week. While using Methotrexate, drink lots of fluids to remain hydrated. Taking folic acid as prescribed by your doctor is essential. This will help to reduce the severity of Methotrexate's harmful effects. Avoid drinking alcoholic beverages while taking Methotrexate because it may increase the chance of adverse effects. Pregnant women should avoid taking Methotrexate. It is recommended that you wait at least 6 months following your last dosage before becoming pregnant.

Frequently asked questions

No, it is not safe to take Methotrexate while pregnant because there is clear evidence that the drug causes a risk to the growing fetus. However, it is used in pregnancy only if the doctor determines its benefits and minimises the risks.

Within 12 to 24 hours, you must experience the benefit of Methotrexate.

No, it's likely unsafe to take Methotrexate during breastfeeding. According to limited human data, the medicine may enter the breast milk and harm the unborn baby.

Yes, it should be used with precaution, specifically if you have a history of kidney disorders or problems. Some patients may need a dosage modification of Methotrexate. If you have any problems, you should consult your doctor.

Yes, it should be used with precaution, specifically if you have a history of liver disorders or problems. Some patients may need a dosage modification of Methotrexate. If you have any problems, you should consult your doctor.

It is not recommended to use any pain relievers (celecoxib, acetaminophen, hydrocodone), antidepressants (duloxetine), immunosuppressants (etanercept), anti-rheumatoid (adalimumab), antacids (esomeprazole), and antimalarials (hydroxychloroquine). Before using any prescription or over-the-counter medications, you must consult your doctor.

Do not use Methotrexate if you have an allergic reaction (hypersensitivity) to any of its components. Do not take it if you drink alcohol. Due to a possible interaction, it may increase the chance of serious adverse effects. We recommend that you consult a doctor as soon as possible.

No, please do not stop taking it without first consulting your doctor. There is a chance that symptoms may return if Methotrexate is suddenly stopped.

Yes, there is some evidence that Methotrexate may have an effect on a male or female's fertility. It is possible that it will reduce the number of sperm in men and cause menstrual abnormalities in women. These symptoms are temporary and will disappear once the treatment is discontinued.

No, avoid consuming alcohol while taking Methotrexate because it could increase dizziness and drowsiness.

Yes, in some people taking Methotrexate, it can cause mouth sores and ulcers. It's possible that taking folic acid with this medication might help minimise the ulcer's sensitivity.

Yes, using it can cause you to feel nausea and vomiting. If you vomit, drink water or other liquids continuously in small quantities. If you observe symptoms of dehydration, such as persistent vomiting, dark urine with a strong odour, or infrequent urination, consult your doctor. Without first consulting a doctor, avoid taking any additional medications.

Yes, Diarrhoea is a risk after taking Methotrexate. Therefore, drink lots of fluids and take probiotics to avoid excessive fluid loss (dehydration). Do not use the anti-Diarrhoea medication by yourself; if the disease worsens, consult your doctor.

Yes, it increases the risk of chronic diseases because it causes leukopenia (a reduction in white blood cells). If you have symptoms of infection, such as a fever, a sore throat, breathing difficulties, jaundice, or heavy, unusual bleeding or bruising, you should consult a doctor.

Terms & Conditions

Available medicines for METHOTREXATE
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Folitrax 2.5 Tablet 10
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