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Pioglitazone

ANTIDIABETIC

Uses of Pioglitazone

  • Pioglitazone is used to treat type 2 diabetes mellitus by helping to lower high blood sugar levels. It can be used on its own or in combination with other medications such as insulin, metformin, or sulfonylurea agents.

Side effects of Pioglitazone

  • Hypoglycemia 
  • Oedema 
  • Upper Respiratory Tract Infection 
  • Bronchitis 
  • Anaemia

How Pioglitazone works

  • Pioglitazone falls under the thiazolidinediones antidiabetic agent category. It reduces the quantity of glucose produced by the liver and increases the sensitivity of tissues to the actions of insulin. It is a selective agonist at peroxisome proliferator-activated receptor-gamma (PPAR) in insulin-target tissues such as adipose tissue, skeletal muscle, and liver.

Certified content

Written By

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Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

  • It is important to take Pioglitazone at the same time every day because this will help you remember to take the medication. It is possible that Pioglitazone when combined with other antidiabetic medications, alcohol, or when meals are delayed or missed, can result in hypoglycemia. You should only take it for the recommended amount of time and dosage your doctor prescribed. After taking Pioglitazone for a few weeks, you could start to experience its full benefits of it. Continue to take it in the manner that your doctor recommended. Doctors recommend taking Pioglitazone to control your blood sugar level and minimise the risk of long-term diabetes complications. Always keep some sweet food or fruit juice with you in case you start experiencing signs of hypoglycemia, such as cold sweats, chilly pale skin, tremors, and anxiety. While taking Pioglitazone, you should monitor your blood sugar frequently. While taking Pioglitazone, you should maintain your regular exercise routine, maintain a balanced diet, and take any additional diabetic medications as recommended by your doctor. Make sure to inform your doctor as soon as possible if you suffer any deep or fast breathing or if you have persistent nausea, vomiting, and stomach pain is important because Pioglitazone may cause a condition called lactic acidosis, which is an excess of lactic acid in the blood but may have serious consequences. This condition is rare but can be life-threatening. It's possible that your doctor can monitor your liver function frequently. Consult your doctor as soon as possible if you have any symptoms, including stomach pain, lack of appetite, yellowing of the eyes or skin (jaundice), or any other abnormal changes.

Frequently asked questions

No, using it during pregnancy may not be safe. Although there is a lack of information in human research, there is evidence from animal studies that this is harmful to a fetus. Your doctor will consider the risks and benefits before a prescription is given. Please consult your physician.

Within 2–4 hours, you must experience the benefit of Pioglitazone.

No, if you are breastfeeding, you should not use Pioglitazone without first consulting your doctor. It is unknown whether or not this medication passes into breast milk. It is not recommended to be used during breastfeeding unless your doctor considers it necessary.

Yes, it's likely safe to take in kidney disease patients. No modification to the dosage is recommended. If you have any problems, you should consult your doctor.

Yes, it should be used with precaution, specifically if you have a history of liver disorders or problems. Some patients may need a dosage modification of the medicine. If you have any problems, you should consult your doctor.

It is not recommended to use any diabetes medications (gemfibrozil), as well as antibiotics (rifampicin). Before using any prescription or over-the-counter medications, you must consult your doctor.

Do not use it if you have an allergic reaction (hypersensitivity) to any of its components. Do not take Pioglitazone if you take foods rich in sugar. Due to a possible interaction, Pioglitazone worsens the condition of diabetes. We recommend that you consult a doctor as soon as possible.

No, stopping it suddenly increases the chance of type 2 diabetes. You must take it for as long as your doctor prescribes.

Yes, it can cause low blood pressure (hypoglycemia). It is characterised by nausea, headache, irritability, hunger, perspiration, vertigo, a rapid heart rate, and feelings of anxiety or shivering.

No, it is unlikely to affect fertility in either men or women. However, there is currently insufficient evidence to justify any clear conclusion. Consult your doctor for the most accurate information.

Yes, there is some evidence that Pioglitazone may lead to an increase in weight for some people. If you want to prevent this, your doctor will likely recommend that you keep to a balanced diet and participate in regular physical exercise. However, if you notice any weight gain in combination with inflammation of body parts (such as in your face, legs, or hands), you must make an appointment with your physician as soon as possible.

No, Alcohol should be avoided because Pioglitazone could increase adverse effects such as lactic acidosis and increase the chance of low blood sugar.

Yes, there is evidence that it increases the risk of bone fractures in some people. You should notify your doctor if you have any bone abnormalities or are at risk for bone fractures before using Pioglitazone.

Yes, it may cause sleepiness. While using Pioglitazone, it is recommended that you should not drive or operate heavy machinery. Relaxing until you feel better if you are experiencing sleep or dizziness is suggested.

No, combining it with insulin is not recommended due to the increased risk of hypoglycemia (decreased blood sugar levels). Before using Pioglitazone with insulin, consult your doctor.

Terms & Conditions


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