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Piperacillin + Tazobactam

Uses of Piperacillin + Tazobactam

  • Piperacillin + Tazobactam is a combination antibiotic primarily used to manage severe bacterial infections, including intra-abdominal, respiratory, skin, and gynaecological infections.

  • It is also used to manage hospital-acquired pneumonia, community-acquired pneumonia, and infections such as pelvic inflammatory disease in adults.

Side effects of Piperacillin + Tazobactam

  • Diarrhoea

  • Nausea

  • Vomiting

  • Rashes

  • Headaches

  • Insomnia

How Piperacillin + Tazobactam works

  • Piperacillin + Tazobactam is used for the treatment of appendicitis and peritonitis.

  • Piperacillin + Tazobactam is a combination antibiotic.

  • Piperacillin, an extended-spectrum penicillin, works by attaching itself to the proteins that assemble the bacterial cell wall. This attachment interrupts the construction of the cell wall, leading to the bacteria bursting and dying.

  • Tazobactam, a β-lactamase inhibitor, blocks the action of β-lactamases, which are bacterial enzymes that deactivate penicillin antibiotics like Piperacillin. By inhibiting these enzymes, Tazobactam ensures Piperacillin remains effective.

  • These two components work together to extend the range of bacteria that can be targeted, making it particularly effective against many forms of bacterial infections.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Piperacillin + Tazobactam is available as a freeze-dried powder that needs to be reconstituted and diluted before administration.

  • It is administered intravenously only by a qualified healthcare professional, commonly in a hospital or healthcare facility setting.

Age and Dose Restrictions

  • This medicine can be administered to adults, and children over the age of 2 months.

Contraindications

  • This medicine is contraindicated in patients who have a history of severe allergic reactions to Piperacillin, Tazobactam, other penicillins, cephalosporins, or β-lactamase inhibitors.

Other Medications to Avoid with This Medicine

  • Piperacillin + Tazobactam may interact with aminoglycoside antibiotics (such as gentamicin and amikacin) and anticoagulants (like warfarin and heparin).

Overdose and Missed Dose

  • An overdose of this medicine may lead to severe side effects such as gastrointestinal upset or neurological symptoms. If you suspect an overdose, contact your doctor immediately.

  • If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue your regular dosage schedule.

Management of Side Effects

Most side effects are temporary, generally harmless, and are resolved once this medicine is stopped. However, if you experience severe side effects or worsening symptoms, please consult your doctor.

  • To avoid dehydration caused by diarrhoea or vomiting, ensure you drink plenty of fluids.

  • Consuming bland, light meals can help manage nausea.

  • Rest and relaxation techniques can aid in managing side effects like headaches or insomnia.

Use in Driving and Operating Machinery

  • Piperacillin + Tazobactam does not typically affect your ability to drive or operate heavy machinery. However, if you feel unwell or experience side effects such as dizziness or fatigue, avoid these activities until you feel better.

Use in Pregnancy and Lactation

  • Piperacillin + Tazobactam should be used in pregnancy only if your doctor determines that it is clearly needed, and the benefit outweighs the risk to the foetus.

  • This medicine is passed into breast milk in low concentrations. Always consult your doctor if you are pregnant or breastfeeding before starting this medication.

Caution in Other Conditions

  • Patients with kidney impairment should consult a doctor before using this medicine, as dosage adjustments may be necessary.

  • Patients with a history of seizures, cystic fibrosis, gastrointestinal disorders like colitis, and cardiac diseases should also take this medicine with caution.

Special Dietary and Lifestyle Recommendation

  • Maintain good hygiene to prevent recurrent infections.

  • Get vaccinated regularly to boost immunity against infections.

  • Avoid close contact with people who have infectious diseases.

  • Drink plenty of fluids and maintain a balanced diet for overall health.

  • Regular sleep and stress management techniques can support a healthy immune system.

Frequently asked questions

No, Piperacillin + Tazobactam is not a steroid. It is a combination antibiotic that consists of the extended-spectrum penicillin, Piperacillin, and the β-lactamase inhibitor, Tazobactam.

Yes, insomnia is reported as one of the side effects of this medicine, but it does not generally affect sleep unless you are experiencing this side effect.

There is no evidence to suggest that this medicine has any impact on fertility. However, if you have concerns, please discuss them with your doctor before using this medicine.

There are no specific dietary restrictions while on this medicine, unless your doctor specifies otherwise.

Yes, it is safe to use Piperacillin + Tazobactam daily, as long as it is administered by a qualified healthcare professional according to the doctor's prescription and guidance.

The time for Piperacillin + Tazobactam to show its effect may vary depending on the type and severity of the infection being managed.

Piperacillin + Tazobactam is generally administered at regular intervals throughout the day, as prescribed by your doctor.

Terms & Conditions


Available medicines for PIPERACILLIN + TAZOBACTAM
Pipzar 4.5 Injection 1
Pipzar 4.5 Injection 1
Intas Pharmaceuticals Ltd
Pack of 1 Units
₹223.21
MRP ₹447.31
50.10% OFF
R Piptaz 4.5gm Inection 1
R Piptaz 4.5gm Inection 1
Ipc Healthcare Pvt Ltd
Pack of 1 UNITS
₹225.50
MRP ₹275.00
18.00% OFF
Tazar 4.5g Injection 1
Tazar 4.5g Injection 1
Lupin Ltd
Pack of 1 UNITS
₹258.10
MRP ₹314.75
18.00% OFF
Tazact 4.5gm Injection 1
Tazact 4.5gm Injection 1
Cipla Ltd.
Pack of 4.5 GM
₹366.79
MRP ₹447.30
18.00% OFF
Piptazone 4000/500mg Injection 1
Piptazone 4000/500mg Injection 1
Galpha Laboratories Ltd
Pack of 1 Units
₹182.29
MRP ₹222.30
18.00% OFF
Pipzo 4.5g Injection 1
Pipzo 4.5g Injection 1
Alkem Laboratories Ltd.
Pack of 1 UNITS
₹280.45
MRP ₹342.01
18.00% OFF
Tazomac 4.5gm Injection 1
Tazomac 4.5gm Injection 1
Macleods Pharmaceuticals Pvt.ltd
Pack of 1 UNIT
₹242.91
MRP ₹296.23
18.00% OFF
Vorior 2000/250 MG Injection 1
Vorior 2000/250 MG Injection 1
Hetero Healthcare Ltd
Pack of 1 Units
₹80.53
MRP ₹98.21
18.00% OFF

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