The key use of Pramipexole is in the management of symptoms associated with Parkinson's disease and restless legs syndrome (RLS) in adults. It falls under the category of dopamine agonist medications.
Nausea and vomiting
Constipation
Headache and dizziness
Fatigue
Insomnia or abnormal dreams
Pramipexole is a dopamine receptor agonist.
It works by selectively activating dopamine D2 receptors, particularly the D3 subtype, in the brain's caudate-putamen region. This mimics the action of dopamine, a neurotransmitter that is deficient in Parkinson's disease, improving muscle control and reducing abnormal movements.
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Pramipexole is available as immediate-release (IR) and extended-release (ER) tablets. These tablets are designed for oral administration.
Pramipexole is prescribed for adult use only.
Pramipexole is contraindicated in patients with a known hypersensitivity to the medicine or any of its inactive ingredients.
It is also not recommended for use in combination with other dopamine agonists.
Pramipexole may interact with antipsychotics (such as haloperidol and chlorpromazine), antidepressants (like sertraline) and prokinetic agents (like metoclopramide).
An overdose of Pramipexole can cause symptoms such as nausea, vomiting, hallucinations, and abnormal body movements. If you suspect an overdose, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Most side effects are temporary and may resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, consult your doctor.
Drinking plenty of water can help manage constipation and dry mouth due to this medicine.
Resting and avoiding strenuous activities can help manage feelings of fatigue.
Pramipexole may cause drowsiness, dizziness or sudden onset of sleep. This can affect your ability to drive or operate machinery. Avoid these tasks if you feel affected.
Pramipexole should only be used during pregnancy if the potential benefits outweigh the risks. Consult your doctor if you are pregnant or planning to conceive.
It is not known if Pramipexole is excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.
Caution should be exercised when using Pramipexole in patients with renal impairment, as dose adjustments may be necessary.
Also, patients with a history of hallucinations or psychosis require close monitoring while on this medicine.
Practise good sleep hygiene. This includes maintaining regular sleep and wake times, keeping the bedroom dark and quiet, avoiding caffeine and alcohol close to bedtime, and engaging in relaxing activities before bed.
Regular mental exercises, such as puzzles, reading, and memory games, can help improve cognitive function in Parkinson's disease patients.
Frequently asked questions
Yes, one possible side effect of Pramipexole is that it can cause insomnia or abnormal dreams in some patients. On the other hand, it can also cause sudden onset of sleep during daily activities.
The effects of Pramipexole on fertility can vary depending on the individual patient and the condition that is being managed. It is always best to discuss this with your doctor.
Yes, Pramipexole can affect your sleep. It has been known to cause insomnia and abnormal dreams in some people, and in rare cases, it can lead to sudden onset of sleep during daily activities.
The time for Pramipexole to start showing its effects will vary depending on several factors, including the condition being managed and individual patient response.
Pramipexole can be taken daily, but only as per the dosage and duration advised by your doctor.
The best time to take your dose of Pramipexole depends on your specific condition and how your body responds to treatment. This should be determined by your doctor.
The time required for Pramipexole to start working can vary depending on the individual patient and the condition that is being managed. It is always best to discuss this with your doctor.
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