Prucalopride
Uses of Prucalopride
The primary purpose of Prucalopride is to manage chronic idiopathic constipation (CIC) in adults. It falls under the category of serotonin-4 (5-HT4) receptor agonist medicines.
Side effects of Prucalopride
Headache
Abdominal pain
Nausea
Diarrhoea
Dizziness
How Prucalopride works
Prucalopride is a serotonin-4 (5-HT4) receptor agonist.
It works by stimulating the 5-HT4 receptors in your digestive tract. This action increases the movement and contractions of your intestines, helping to push the contents through your bowels more effectively. By enhancing this gut movement, Prucalopride helps to relieve symptoms of chronic constipation. The medicine accelerates the passing of stools through your digestive system, making it easier for you to empty your bowels regularly and adequately.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Prucalopride can be taken orally (tablet).
Age and Dose Restrictions
This medicine is meant for use in adults aged 18 and above.
Contraindications
Prucalopride is contraindicated in patients with a known hypersensitivity to the medication. It should not be used in patients with intestinal perforation or obstruction caused by structural or functional gut wall disorders, obstructive ileus, or severe inflammatory bowel conditions such as Crohn's disease, ulcerative colitis, toxic megacolon, or megarectum.
Other Medications to Avoid
Prucalopride may interact with other serotonergic medications (such as fluoxetine).
Overdose and Missed Dose
An overdose of Prucalopride may cause exaggerated pharmacological effects, such as diarrhoea and abdominal pain. If you suspect an overdose, contact your doctor immediately.
If you miss a dose of Prucalopride, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Management of Side Effects
Most side effects of Prucalopride are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor. To help manage some side effects:
Drink plenty of fluids to manage diarrhoea.
Rest and avoid sudden movements to manage dizziness.
Use in Driving and Operating Machinery
Prucalopride may cause dizziness or fatigue. If you experience these side effects, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Pregnant and breastfeeding women should consult their doctor before using Prucalopride, as the effect of the medicine on a developing baby and breastfed infant is unknown.
Caution in Other Conditions
Patients with severe renal impairment should exercise caution when taking Prucalopride, as a dosage adjustment may be required. Patients with a history of depression or suicidal ideation should also exercise caution when taking Prucalopride.
Special Dietary and Lifestyle Recommendations
Maintain a high-fibre diet to support bowel health and reduce constipation.
Stay well hydrated by drinking plenty of fluids throughout the day.
Frequently asked questions
Is Prucalopride a steroid?
No, Prucalopride is not a steroid. It belongs to a class of medicines known as serotonin-4 (5-HT4) receptor agonists.
Will Prucalopride affect my appetite?
Prucalopride is not directly associated with affecting appetite. However, side effects like nausea, abdominal pain, and diarrhoea may indirectly affect your appetite.
Does Prucalopride have any impact on fertility?
Prucalopride is not directly associated with affecting fertility. However, if you have concerns, it is best to consult your doctor.
Is it safe to take Prucalopride daily?
Yes, it is safe to take Prucalopride daily as long as it is taken according to the recommended dosage prescribed by your doctor.
How long does it take for Prucalopride to work?
The time it takes for Prucalopride to show its effects can vary among individuals. However, it generally starts working within 2-3 days of administration.
Do I need a prescription to buy Prucalopride?
Yes, you typically need a prescription from a doctor to buy Prucalopride since it is a prescription medicine.
What is the duration of treatment with Prucalopride?
The duration of treatment with Prucalopride should be determined by your doctor based on your medical condition and response to therapy.
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