Isryl M2 Tablet 15

Systopic Laboratories Private Limited

Strip of 15 Units

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MRP ~~₹63.28~~

₹50.62

₹4.22/Units

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Isryl-M2 Tablet is used to manage type 2 diabetes in adults, particularly when blood sugar levels remain high despite single-drug therapy. It combines Glimepiride and Metformin to enhance the body's natural insulin response and suppress glucose production in the liver. This helps in achieving targeted HbA1c levels and reduces the risk of long-term diabetes-related complications.

For the best results, take this tablet with meals as advised by your healthcare provider to maintain stable glucose control. It is important to monitor your blood sugar levels regularly and be aware of symptoms of hypoglycemia, such as dizziness or tremors. Ensure you inform your doctor of any history of kidney problems or recent heart-related events.

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Isryl-M2 Tablet is used to manage blood sugar levels in patients with type 2 diabetes mellitus. It helps maintain effective glycemic control by improving insulin release and sensitivity while reducing glucose production in the liver. Consistent use is vital for preventing long-term diabetic complications.

Follow these instructions while taking the Isryl-M2 Tablet:

Swallow the tablet whole with water.
Avoid crushing, chewing, or breaking the tablet.
Take this medicine with your first meal of the day for the best results.
For specific advice on dosage and duration, consult your doctor.

Isryl-M2 Tablet is taken orally.

Isryl-M2 Tablet may cause hypoglycemia (low blood sugar), nausea, vomiting, diarrhea, abdominal discomfort, and vitamin B12 deficiency. In rare cases, it may cause lactic acidosis or allergic reactions. Seek immediate medical help for breathing difficulty or persistent symptoms.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Isryl-M2 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here's how to manage common side effects:

Hypoglycaemia: Be aware of signs like shaking and sweating. Keep some sugar-rich food handy for immediate relief.
Gastrointestinal disturbances: If you feel nauseous or have an upset stomach after taking the medicine, try consuming it with your main meal.

Isryl-M2 Tablet comprises two crucial components:

Glimepiride (2 mg): This component belongs to the sulfonylurea class of medicines and works by stimulating insulin release from the pancreatic beta cells. Furthermore, it boosts insulin sensitivity in peripheral tissues, which aids in better glucose uptake and utilisation.
Metformin (500 mg): Falling under the biguanide class of medicines, Metformin reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. It also enhances insulin sensitivity in muscle and adipose tissues allowing better peripheral glucose uptake and utilisation. Additionally, Metformin delays glucose absorption from the gastrointestinal tract.

Pregnancy

Caution is advised while taking the Isryl-M2 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss this with your doctor before starting this medicine.

Alcohol

Alcohol consumption could increase the risk of lactic acidosis and hypoglycemia when taking Isryl-M2 Tablet. It is advisable to limit your alcohol intake whilst using this medication.

Liver

If you have liver problems, caution is advised when taking Isryl-M2 Tablet. Glimepiride, one of the components in this medicine, is processed by the liver and dosage adjustment may be required.

Kidney

Isryl-M2 Tablet should be used with caution if you have kidney issues. Your doctor may need to adjust your dosage based on your renal function.

Using Machines & Driving

Hypoglycemia (low blood sugar) can cause dizziness or confusion, which might affect your ability to drive or operate machinery. Exercise caution while performing these activities while on Isryl-M2 Tablet.

Allergy

If you are allergic to Glimepiride, Metformin, or any other ingredients in Isryl-M2 Tablet, avoid using this medicine.

Children

Isryl-M2 Tablet is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Elderly patients should take Isryl-M2 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Isryl-M2 Tablet interacts with the following medicines:

Insulin and other anti-diabetic agents: If taken together with Isryl-M2 Tablet, these medications can increase the risk of hypoglycaemia (low blood sugar). Examples include insulin glargine and insulin lispro.
Thiazide diuretics: Medicines like hydrochlorothiazide may decrease the efficacy of Isryl-M2 Tablet and lead to hyperglycaemia (high blood sugar).
Corticosteroids and sympathomimetic agents: These medications, for example, prednisone and pseudoephedrine, can increase blood glucose levels when taken with Isryl-M2 Tablet.

Drug-Food Interactions

Isryl-M2 Tablet should be taken with your first meal of the day. As it helps manage your blood sugar levels, consuming high-sugar foods or drinks while on this medication may affect its effectiveness.

Drug-Disease Interactions

Isryl-M2 Tablet interacts with the following diseases:

Renal impairment: If you have kidney disease, Isryl-M2 Tablet may require dose adjustment or discontinuation based on your creatinine clearance levels.
Hepatic impairment: As glimepiride, one of the active ingredients in Isryl-M2 Tablet, is metabolised by the liver, dose modification may be needed if you have liver disease.
Type 1 diabetes mellitus and diabetic ketoacidosis: These conditions are contraindications for Isryl-M2 Tablet. This medicine is not suitable for patients with these diseases.

Daily Dose

The daily dose of Isryl-M2 Tablet should be as prescribed by your doctor. Your dosage may be adjusted based on factors such as your response and the severity of your condition. Always consult your doctor before changing the dosage.

Over Dose

Taking more than the prescribed dose of Isryl-M2 Tablet can lead to increased side effects like hypoglycaemia (low blood sugar) and gastrointestinal disturbances like nausea. Should you suspect an overdose, inform your doctor immediately.

Missed Dose

If you forget to take a dose of Isryl-M2 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never double up on doses without consulting your doctor.

Store Isryl-M2 Tablet at room temperature, ideally between 15°C and 30°C.
Keep it in a tightly closed container to safeguard it from moisture.
Avoid direct exposure to sunlight.
Always keep this medicine out of children's reach.
Use the tablet before its expiry date for maximum effectiveness.

Follow a balanced diet rich in fibre and low in sugar to aid the management of your type 2 diabetes. This includes whole grains, fruits, vegetables, and lean proteins.
Engage in regular physical activity such as walking, jogging, or yoga. Regular exercise can help your body use insulin more effectively, contributing to better management of your blood sugar levels.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic

What is Isryl-M2 Tablet used for?

Isryl-M2 Tablet is an oral medication primarily used to manage type 2 diabetes in adults when single medicine therapy is insufficient.

How does Isryl-M2 Tablet work?

It combines two active ingredients, glimepiride and metformin, which work together to lower blood sugar levels by increasing insulin secretion and improving insulin sensitivity.

Can Isryl-M2 Tablet cause any side effects?

Yes, common side effects include low blood sugar, gastrointestinal disturbances, and potential vitamin B12 deficiency. Uncommon but serious side effects like lactic acidosis may also occur.

Who should be cautious while taking Isryl-M2 Tablet?

People with kidney or liver issues, the elderly, and pregnant or breastfeeding women should use this medicine with caution due to increased health risks.

Can I take other medicines while using Isryl-M2 Tablet?

Certain medicines can interact with Isryl-M2 Tablet. You should always inform your doctor about all the medicines you're currently taking.

How should I store my Isryl-M2 Tablet?

Store it at room temperature (15-30°C), protected from moisture and direct sunlight. Keep it out of children's reach in a tightly closed container.

What lifestyle changes should I make while using Isryl-M2 Tablet?

Maintain a balanced diet, engage in regular physical activity, monitor your blood glucose levels regularly, and follow your doctor's advice regarding regular kidney function tests and vitamin B12 monitoring.

Last Updated On 04 Mar. 2026 | 8:48AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

101 PRAGATI CHAMBERS RANJIT NAGAR COMMERCIAL , NEW DELHI, Delhi, India - 110008

Country of origin: INDIA

Expiry on or after: July 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Langtry, H. D., & Balfour, J. A. (1998). Glimepiride. Drugs, 55(4), 563–584. https://doi.org/10.2165/00003495-199855040-00007
Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014). Metformin: From mechanisms of action to therapies. Cell Metabolism, 20(6), 953–966. https://doi.org/10.1016/j.cmet.2014.09.018
Sahay, R. K., Mittal, V., Gopal, G. R., Kota, S., Goyal, G., Abhyankar, M., & Revenkar, S. (2020). Glimepiride and metformin combinations in diabetes comorbidities and complications: Real-World evidence. Curēus. https://doi.org/10.7759/cureus.10700
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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Name: Kishor Kumar

Email: grievance-officer@truemeds.in

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