Cefotaxime
Uses of Cefotaxime
The primary use of Cefotaxime is to manage serious infections caused by susceptible bacteria. It is a third-generation cephalosporin antibiotic.
Cefotaxime is also used for managing various infections including respiratory tract infections such as pneumonia, urinary tract infections, skin and soft tissue infections, bone and joint infections, gynaecological infections, bacteremia and septicemia, meningitis and other central nervous system infections, intra-abdominal infections like peritonitis and genital infections including gonorrhoea. It is also used for surgical prophylaxis to prevent post-operative infections.
Side effects of Cefotaxime
Injection site reactions (pain, inflammation)
Nausea
Vomiting
Diarrhoea
Rash
How Cefotaxime works
Cefotaxime is a third-generation cephalosporin antibiotic.
It works by inhibiting the formation of bacterial cell walls, which are crucial for the bacteria's survival. Cefotaxime does this by targeting and inactivating penicillin-binding proteins (PBPs), which are required for the assembly and strength of the cell wall. The impaired cell wall leads to the breakage of bacterial cells, causing their death effectively. Hence, it manages a wide range of bacterial infections successfully.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Cefotaxime is available for reconstitution and subsequent administration via the parenteral route. It can be given via intravenously or intramuscularly (injection).
Age and Dose Restrictions
This medicine is primarily meant for adults, but can also be used in neonates, infants and children at adjusted doses depending on their weight and age.
Contraindications
Cefotaxime is contraindicated in patients with known hypersensitivity to it or other cephalosporins.
Other Medications to Avoid
Cefotaxime may interact with gout medicine (like probenecid), aminoglycosides (such as gentamicin, amikacin) and diuretics (like furosemide).
Overdose and Missed Dose
Overdose of Cefotaxime can lead to symptoms like nausea, vomiting and diarrhoea. If you suspect an overdose, seek immediate medical attention.
In case you miss a dose of Cefotaxime, administer it as soon as you remember. But if it's almost time for the next scheduled dose, skip the missed one. Do not double the dose to compensate for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Ensure to drink plenty of water to manage gastrointestinal disturbances like nausea or diarrhoea.
For managing injection site reactions like pain or inflammation, applying a cold pack can help.
Use in Driving and Operating Machinery
Cefotaxime does not directly affect the ability to drive or operate heavy machinery. However, if you experience side effects like dizziness and/or fatigue, it is advisable to avoid such activities.
Use in Pregnancy and Lactation
Cefotaxime should be used during pregnancy only if clearly necessary. It is excreted in low levels in breast milk, therefore, lactating mothers should consult their doctor before using it.
Caution in Other Conditions
Caution should be exercised in patients with renal impairment as dosage adjustment may be required. Patients with a history of colitis or seizure disorders should also exercise caution when using Cefotaxime.
Special Dietary and Lifestyle Recommendations
Maintaining good personal hygiene can help avoid bacterial infections which require treatment with antibiotics like Cefotaxime.
Frequently asked questions
Is Cefotaxime a painkiller?
No, Cefotaxime is not a painkiller. It is an antibiotic used for managing various types of bacterial infections.
Can Cefotaxime cause mood changes?
Cefotaxime is not directly associated with causing mood changes. However, if you notice any unusual changes in your mood or behaviour, consult your doctor.
Does Cefotaxime have any effect on menstruation?
No known effect of Cefotaxime on menstruation has been reported. If you notice any changes in your menstrual cycle while using this medicine, consult your doctor.
Can Cefotaxime cause allergic reactions?
Yes, in rare cases, Cefotaxime can cause allergic reactions, including rash, pruritus (itching), urticaria (hives) and angioedema (swelling under the skin).
Does Cefotaxime have any impact on appetite?
No known impact of Cefotaxime on appetite has been reported. If you experience changes in your appetite while on this medication, inform your doctor.
Can Cefotaxime be used as a substitute for other antibiotics?
Cefotaxime should not be used as a substitute for other antibiotics unless advised by a doctor. Each antibiotic has a specific spectrum of activity and is chosen based on the type of infection and the causative bacteria.
Can Cefotaxime be given to vegetarian or vegan patients?
Yes, as an injectable antibiotic, Cefotaxime should be suitable for vegetarians and vegans. However, it is always best to consult with your doctor if you have any dietary restrictions or preferences.
Cefotaxime in other salts
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