Rivaroxaban

Dosage Forms Available

• Rivaroxaban is available for oral use in the form of film-coated tablets.

• A special formulation of Rivaroxaban, as a 1mg/mL oral suspension, is also available for paediatric use.

Age and Dose Restrictions

• Rivaroxaban is intended for use in adults for a variety of indications. It is also approved for children aged 2 years and older with specific medical conditions, such as congenital heart disease.

Contraindications

• Rivaroxaban is contraindicated in patients with active pathological bleeding.

• It should not be used in patients who have severe hypersensitivity reactions to Rivaroxaban.

• The medication is also contraindicated in patients with mechanical prosthetic heart valves.

Other Medications to Avoid

• Rivaroxaban can interact with P-gp and strong CYP3A4 inhibitors (such as ketoconazole and ritonavir), leading to increased exposure and bleeding risk.

• Caution should be exercised when using anticoagulants (warfarin), fibrinolytic (st, and NSAIDs concurrently with Rivaroxaban due to the increased risk of bleeding.

Overdose and Missed Dose

• Overdosing on Rivaroxaban can potentially lead to excessive bleeding. If you suspect an overdose, seek medical help immediately.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up the dose to catch up.

Management of Side Effects

Most side effects of Rivaroxaban are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage minor bleeding side effects, such as nosebleeds and heavy menstrual bleeding.

• Resting in a comfortable position can help manage dizziness.

Use in Driving and Operating Machinery

• Rivaroxaban may cause dizziness or fainting in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Rivaroxaban should only be used during pregnancy and breastfeeding if clearly needed and after consulting your doctor.

Caution in Other Conditions

• Caution should be exercised when using Rivaroxaban in patients with renal impairment, as the risk of bleeding is higher in these individuals.

• Patients with uncontrolled hypertension or recent intracranial haemorrhage should also exercise caution when using Rivaroxaban.

Special Dietary and Lifestyle Recommendations

• Maintaining a healthy lifestyle that includes a balanced diet and regular physical activity can promote overall cardiovascular health.

• Avoiding habits such as smoking and excessive alcohol consumption can further help reduce the risk of developing blood clots.

• Regular check-ups with your doctor are recommended to monitor your condition while on Rivaroxaban.