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Rivaroxaban

Uses of Rivaroxaban

  • Rivaroxaban is primarily used as an anticoagulant to prevent and manage blood clots. It belongs to the class of medicines known as Factor Xa inhibitors.

  • Besides this, Rivaroxaban is also indicated for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation, treating deep vein thrombosis (DVT) and pulmonary embolism (PE), reducing the risk of recurrence of DVT and PE after initial treatment, and prophylaxis of DVT in patients undergoing knee or hip replacement surgery.

Side effects of Rivaroxaban

  • Bleeding

  • Heavy menstrual bleeding

  • Nosebleeds

  • Gastrointestinal bleeding

  • Hematuria (blood in urine)

How Rivaroxaban works

  • Rivaroxaban is a type of anticoagulant, specifically known as a Factor Xa inhibitor.

  • It works by directly blocking the function of a key component, Factor Xa, in the process of blood clotting called the coagulation cascade. This process involves a series of chemical reactions that lead to the formation of a clot.

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Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Rivaroxaban is available for oral use in the form of film-coated tablets.

  • A special formulation of Rivaroxaban, as a 1mg/mL oral suspension, is also available for paediatric use.

Age and Dose Restrictions

  • Rivaroxaban is intended for use in adults for a variety of indications. It is also approved for children aged 2 years and older with specific medical conditions, such as congenital heart disease.

Contraindications

  • Rivaroxaban is contraindicated in patients with active pathological bleeding.

  • It should not be used in patients who have severe hypersensitivity reactions to Rivaroxaban.

  • The medication is also contraindicated in patients with mechanical prosthetic heart valves.

Other Medications to Avoid

  • Rivaroxaban can interact with P-gp and strong CYP3A4 inhibitors (such as ketoconazole and ritonavir), leading to increased exposure and bleeding risk.

  • Caution should be exercised when using anticoagulants (warfarin), fibrinolytic (st, and NSAIDs concurrently with Rivaroxaban due to the increased risk of bleeding.

Overdose and Missed Dose

  • Overdosing on Rivaroxaban can potentially lead to excessive bleeding. If you suspect an overdose, seek medical help immediately.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up the dose to catch up.

Management of Side Effects

Most side effects of Rivaroxaban are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help manage minor bleeding side effects, such as nosebleeds and heavy menstrual bleeding.

  • Resting in a comfortable position can help manage dizziness.

Use in Driving and Operating Machinery

  • Rivaroxaban may cause dizziness or fainting in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Rivaroxaban should only be used during pregnancy and breastfeeding if clearly needed and after consulting your doctor.

Caution in Other Conditions

  • Caution should be exercised when using Rivaroxaban in patients with renal impairment, as the risk of bleeding is higher in these individuals.

  • Patients with uncontrolled hypertension or recent intracranial haemorrhage should also exercise caution when using Rivaroxaban.

Special Dietary and Lifestyle Recommendations

  • Maintaining a healthy lifestyle that includes a balanced diet and regular physical activity can promote overall cardiovascular health.

  • Avoiding habits such as smoking and excessive alcohol consumption can further help reduce the risk of developing blood clots.

  • Regular check-ups with your doctor are recommended to monitor your condition while on Rivaroxaban.

Frequently asked questions

Rivaroxaban is typically safe for long-term use, as recommended by your doctor. However, Always consult your doctor for advice about its prolonged usage.

You should not stop taking Rivaroxaban without consulting your doctor. Stopping the medicine abruptly can increase your risk of blood clots or stroke.

There is no established link between Rivaroxaban and mood changes or impact on mental well-being. However, if you notice any unusual mood changes while taking this medicine, please consult your doctor promptly.

Rivaroxaban can affect certain coagulation tests such as prothrombin time (PT) and activated partial thromboplastin time (aPTT), making them unreliable for assessing its anticoagulant effect.

No, there is no evidence that Rivaroxaban is addictive or leads to substance dependency.

Rivaroxaban is not available over the counter. It is a prescription medicine, meaning that it can only be obtained with a valid prescription from a doctor.

The duration of treatment with Rivaroxaban depends upon the medical condition for which it is being used and the patient's response to treatment. Your doctor will provide guidance on how long you need to continue the medication.

Terms & Conditions

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