Ambrisentan
Uses of Ambrisentan
The primary use of Ambrisentan is in the management of pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that carry blood from the heart to the lungs. The medicine belongs to a class of medicines known as endothelin receptor antagonists.
Side effects of Ambrisentan
Peripheral oedema
Nasal congestion
Sinusitis
Abdominal pain
Headache
How Ambrisentan works
Ambrisentan is an Endothelin Receptor Antagonist (EAR). It works by blocking the action of a natural substance called endothelin that is produced in the body. Endothelin causes blood vessels to narrow and by blocking its action, Ambrisentan helps blood vessels in the lungs to relax and widen.
This reduces the pressure within these vessels, allowing blood to flow more easily from the heart to the lungs. This action ultimately helps reduce the symptoms of diseases such as Pulmonary Arterial Hypertension.
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Expert Advice
Dosage forms available
Ambrisentan is available for use via the oral route (tablets).
Age and dose restrictions
This medicine is meant for use by adults and children over the age of 12 years.
Contraindications
Ambrisentan is contraindicated in patients with known allergies to Ambrisentan.
This medicine is also contraindicated in patients diagnosed with idiopathic pulmonary fibrosis (IPF).
Other medications to avoid
Ambrisentan may interact with immunosuppressants (cyclosporine such as gengraf and neoral) and strong CYP3A and CYP2C19 inhibitors which includes anti-fungals and anti-viral (such as ketoconazole, fluconazole and ritonavir).
Overdose and missed dose
An overdose of this medication may cause symptoms like headaches, hot flashes or nausea. If you observe any such symptoms, inform your doctor promptly.
If you forget to take your dose of Ambrisentan, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one. Do not double up the dose to make up for the missed one.
Management of side effects
Most side effects of Ambrisentan are temporary and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.
Drinking plenty of fluids can help manage headaches.
Taking the medication at bedtime might mitigate some side effects like flushing or palpitations.
Use in driving and operating machinery
This medication may cause dizziness or fatigue, which may affect your ability to drive or operate heavy machinery. If you feel dizzy or tired after taking Ambrisentan, avoid driving or any activities that require mental focus.
Use in pregnancy and lactation
It is advisable to consult a doctor before using Ambrisentan during pregnancy and breastfeeding.
Caution in other conditions
Patients with liver disease should exercise caution when taking Ambrisentan due to potential liver injury.
Ambrisentan is also contraindicated in patients with anaemia due to the risk of decreasing haemoglobin levels.
Special dietary and lifestyle recommendations
Regular exercise and maintaining a healthy weight can help manage symptoms of pulmonary arterial hypertension (PAH).
Eating a low-sodium diet can help manage fluid retention associated with PAH.
Frequently asked questions
Is Ambrisentan a steroid?
No, Ambrisentan is not a steroid. It belongs to a group of medicines known as endothelin receptor antagonists.
Does Ambrisentan have any effect on sleep?
Ambrisentan is not directly associated with affecting sleep. However, if you experience unusual tiredness or other sleep disturbances while taking this medicine, it is important to discuss this with your doctor.
Will Ambrisentan affect fertility?
Ambrisentan is not associated with affecting fertility in humans. However, if you are planning to conceive, it is crucial to discuss this with your doctor before starting this medication.
Is it safe to take Ambrisentan daily?
Yes, it is typically safe to take Ambrisentan daily as prescribed by your doctor. The medicine is designed for long-term management of PAH symptoms and should be taken consistently for optimal benefits.
How much time does Ambrisentan take to work?
The time Ambrisentan takes to work can vary from person to person. Some individuals may notice improvements in their (PAH) pulmonary arterial hypertension symptoms within a few weeks, while for others it may take longer.
What is the best time to take Ambrisentan?
Ambrisentan is usually taken as advised by your doctor at approximately the same time each day. It can be taken with or without food.
Is Ambrisentan a vegetarian medicine?
Ambrisentan is a synthetic medicine. The active ingredient is chemically synthesized and does not contain any animal-derived ingredients. However, consult with your pharmacist to confirm the ingredients of the brand you are prescribed.
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